To compare the clinical outcomes of unilateral biportal endoscopic discectomy (UBED) and percutaneous interlaminar endoscopic discectomy (PIED) for treating L5/S1 disc herniation. Patients with L5/S1 disc herniation treated with UBED (n=46) and PIED (n=50) in our hospital during the same period were retrospectively reviewed. Clinical outcome, radiographic parameters and complications of each group were collected and evaluated. The mean follow-up period was 14.11±3.47 months in UBED group, and 14.52±5.37 months in PIED group. There was no significant difference in VAS leg (P=0.836) or lumbar scores (P=0.335) between PIED and UBED group at preoperative, 1-day postoperative, and last follow-up point. Within the same group, there were significant differences in VAS leg (P<0.001) and lumbar scores (P<0.001) compared pairwise at three time points. ODI scores of both groups showed significant improvement at the last follow-up (P<0.001) (P<0.001). And there was no significant difference in patient satisfaction rates (97.8% vs 96%) between two groups based on MacNab criteria. The percentage of facet joint preservation was 96.74±9.10% in UBED group, and 99.22±1.52% in PIED group. The total blood loss and hospitalization cost was more in the UBED Group. One patient in both groups showed postoperative hematoma. A dural tear occurred in UBED group and a never root injury occurred in PIED group. UBED indicates similar short-term efficacy compared with PIED for treating L5/S1 disc herniation. No difference was found in facet joint preservation between two groups. The increased cost of UBED due to surgical consumables is believed to be resolved in the future.
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