An open-source simulation model for aircraft noise prediction is presented and validated using backpropagated noise measurements for a state-of-the-art engine and aircraft. The validation is focused on approach procedures and was performed using ground-based noise measurements that were taken at 17 recording stations for a total of 18 consecutive flights carried out during the morning of 8 April 2021. The flights were performed using two A321neo aircraft with LEAP-1A engines. It is demonstrated that the presented noise model provides a satisfactory estimation of the source noise for varying approach configurations and flight conditions. Configurations using a greater number of high-lift devices are particularly well predicted in the mid- and high-frequency regions, whereas the lower configuration settings show greater spectral deviations, which are partly attributed to measurement uncertainties caused by the increased aircraft–microphone distance. The model can predict the overall mean total sound intensity level within a 2 dB accuracy for all configurations, while the average predicted level at each microphone differs by less than 3 dB from the measurement average, for all cases except one. Variation in aircraft speed showed to have a strong impact on the predicted total noise, which matches the well-recognized sixth-power Mach number far-field sound intensity scaling law for airframe noise models, while the measurements indicated a less significant dependency. This is mainly due to installation effects and noise reduction measures that are not included in the models. Nevertheless, the variations in the spectra of the predicted and measured noise showed similar patterns.