Presentation Of Posterior Urethral Valves Research Articles

Comparison of outcomes of prenatal versus postnatal presentation of posterior urethral valves: a systematic review and meta-analysis.

To determine through a comprehensive systematic review and meta-analysis the differences in the outcomes of prenatally versus postnatally diagnosed posterior urethral valves (PUV) to ascertain if prenatal detection of PUV has superior outcomes. We conducted a systematic review and meta-analysis in March 2022 (PROSPERO ID - CRD42021243546) and included all studies that reported outcomes of prenatally and postnatally diagnosed PUV. However, for meta-analysis, only those studies that described both groups were included. The main outcomes of interest included progression of chronic kidney disease (CKD), need for renal replacement therapy (RRT) and renal transplant, and bladder dysfunction as determined by initiation of clean intermittent catheterization (CIC). Time to event analyses were completed when possible. The systematic review included 49 studies (3820 patients). The pooled effect estimates for progression to CKD (OR 0.75 [95% CI 0.43, 1.31]), need for RRT (OR 1.39 [95% CI 0.64, 2.99]) and need for renal transplant (OR 1.64 [95% CI 0.61, 4.42]) between prenatal and postnatal groups was not different. CICs rates were as high as 32% in the prenatal group and 22% in the postnatal group. Most studies had a moderate or serious risk of bias. The existing comparative literature on prenatal versus postnatal presentation of PUV is very heterogeneous. The diagnostic and treatment protocols have not been reported in majority of the studies. The outcome variables are also reported inconsistently. Based on the current evidence, prenatal diagnosis of PUV does not appear to improve the long-term outcomes of these patients.

Posterior üretral valvin nadir bir klinik bulgusu: Tekrarlayan epididimo-orşit

Recurrent epididymo-orchitis is a rare condition in children. Considering that obstructive infravesical pathologies, such as posterior urethral valves, may cause recurring epididymo-orchitis in children, a thorough examination of the genito-urinary system will prove essential for the diagnosis and treatment of the main pathology. We herein present a case of posterior urethral valve presenting with recurrent episodes of epididymo-orchitis.

Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience.

ObjectiveEvaluate renal outcomes and early predictive factors in infants with congenital posterior urethral valves who required catheter or surgical urinary tract decompression within the first 7 days of life.Study designA 10-year retrospective study at a single hospital. Primary outcomes were estimated glomerular filtration rate (eGFR) and development of end stage renal disease (ESRD).ResultsOf 35 infants, 50% developed eGFR <90 mL/min/1.73 m2 and 15% progressed to ESRD. Nadir creatinine, need for invasive ventilation in the newborn period, and need for surgical diversion after catheter diversion were associated with worse outcomes. 50% of infants requiring invasive ventilation as neonates developed eGFR <60 mL/min/1.73 m2 in childhood.ConclusionsHalf of infants with early presentation and intervention developed significant renal insufficiency in childhood, similar to children with later presentation or who had fetal intervention. Invasive ventilation in the newborn period and need for surgical urinary diversion are associated with worse outcomes.

Does Voiding Cystourethrogram Exclude Posterior Urethral Valves in Late Presenting Cases?

Delayed presentation of posterior urethral valves (PUVs) is a rare condition. Presentation and diagnosis of the patients with late PUVs are challenging. Voiding cystourethrogram (VCUG) is mainly practiced. In this study, we aimed to evaluate the children with late-presented PUVs, and the reliability of VCUG in this group. Between January 2003 and December 2017 records of patients who were diagnosed with late-presented PUVs were analyzed. Delayed presentation of PUV was defined as patients who were diagnosed and treated after infancy. Cases were examined in terms of age at diagnosis, presenting symptoms, urinalysis, urinary ultrasound, urodynamic studies, VCUG, and dimercaptosuccinic acid scintigraphy findings. Postoperative follow-up conditions were also assessed. Seventeen boys were diagnosed with late-presented PUVs (mean age was 7.35 years). The most common symptoms at presentation were frequency (58.8%), day and nighttime incontinence (47%), and febrile urinary infection (41%). PUV was noted by VCUG in 10 patients alone. The classical sign of dilated posterior urethra was detected in 9 patients. The 10th patient had posterior urethral irregularity. Urethra could not be evaluated due to unsuccessful voiding in one patient. Six patients had normally appearing urethra on VCUG. Reflux was detected in nine (52.9%) patients. Late-presented PUVs may be missed on VCUG. Whether a PUV might be present is crucial in boys with a history of recurrent urinary infection, persistent reflux, and repetitive daytime incontinence. Based on our results, we conclude that cystoscopic examination should be preferred for those cases to diagnose PUVs regardless of VCUG results.

Posterior urethral valves in fraternal twins

We report a pair of dizygotic twins with type 1 posterior urethral valves. Concomitant and discordant presentation of posterior urethral valves in twins is rare, with a handful of cases in the literature. The occurrence of identical pathology in dizygotic twins probably suggests the possibility of an inherited trait as it does exist in monozygotic twins.Keywords: fraternal twins, identical pathology, inherited trait, posterior urethral valves

Urinoma Secondary to Posterior Urethral Valve Presenting with Features of Intestinal Obstruction in a Neonate: A Case Report

Urinoma Secondary to Posterior Urethral Valve Presenting with Features of Intestinal Obstruction in a Neonate: A Case Report

Posterior urethral valve presenting with urethral stone: a challenging diagnosis

Posterior urethral valve is one of the most common causes of urethral obstruction in male neonates. Posterior urethral valve is now a day commonly diagnosed in prenatal USG. PUV can cause symptoms ranging from pulmonary hypoplasia to renal insufficiency. We are presenting a case report of a rare association of a large urethral calculus secondary to Posterior urethral valve in a 4 years old child who presented with difficulty while micturition. PUV is common finding in male children, which mainly presents with difficult micturition. This case was a rare association of urethral calculi secondary to valves presenting with painful micturition.

Early versus delayed presentation of posterior urethral valves in children: Consequences and outcome of vesico-ureteric reflux

Introduction: Delayed presentation of patients with posterior urethral valve (PUV) is common in our country and is usually associated with complications and morbidities. Objective: To determine the pattern of presentation of PUVs and its complications and outcomes in these patients with respect to decrease or resolution of vesico-ureteric reflux (VUR) and/or requirement of additional operative procedures. Materials and Methods: A retrospective study was conducted, and 30 children of PUV were analyzed with respect to the pattern of presentation, duration of symptoms, age at primary fulguration, grade of VUR and its outcome. Results: Patients with early presentation were diagnosed early, had their PUV fulgurated early and had lesser grades and better resolution of their VUR and good outcome. The reverse was seen in those patients who presented late and already had some form of renal impairment such as higher and bilateral grades of VUR and higher serum creatinine levels. Some of them also required additional procedures which added to their morbidity. Discussion: Delayed presentation of PUV is common in our country and is associated with an increased incidence and a higher grade of VUR which does not decrease or resolve on follow-up and usually requires additional operative interventions adding to the morbidity of both the parents and the child. On the other hand, early presentation leads to early diagnosis and early relief of obstruction and is associated with lesser VUR, which resolves over time. Conclusion: With early presentation, diagnosis and treatment, the outcome of patients with PUVs is expected to improve. Efforts at improving awareness and early diagnosis and referral among the health team should be encouraged.

Lower abdominal mass in a 16-year old adolescent: an unusual presentation of posterior urethral valves

Posterior urethral valves (PUV) are now commonly suspected onantenatal ultrasound, but can present with a broad spectrum ofseverity postnatally. Rarely, the diagnosis is missed until adolescenceor adulthood when the patient usually presents with lowerurinary tract symptoms. We describe an even rarer case of PUV inan adolescent who first presented with renal failure and a palpablelower abdominal mass due to urinary retention. We review theliterature on presentation, natural history and outcomes of bothearly and late presenting PUV cases.

Delayed Presentation of Posterior Urethral Valves in Discordant Twins

Concordant and discordant presentations of posterior urethral valves (PUV) in twins have been described. Twin gestation may complicate the diagnosis of PUV based on prenatal evaluation. A case series of 2 sets of twin births is presented, each of which was discordant for the diagnosis of PUV. A delay in diagnosis occurred in both cases, despite prenatal ultrasound abnormalities. This delay could result from failed sensitivity of prenatal ultrasound or from postnatal evaluation of the incorrect twin. Caution must be exercised during follow-up of abnormalities identified on prenatal ultrasound in diseases in which there are no external distinguishing characteristics.

Outcome of Late Presentation of Posterior Urethral Valves in a Resource-Limited Economy: Challenges in Management

Delayed presentation of patients with posterior urethral valve with complications like severe urosepsis, uremia, and anemia are seen in our setting. Renal replacement therapy which should have been offered to these patients is not readily available for children in our country. The aim of this study is to determine the pattern of late presentation and outcome of management of posterior urethral valve in a resource-limited setting. A descriptive retrospective study (1997–2009) was conducted. Data including pattern of presentation, duration of symptoms, complications, and outcome of initial management were analyzed. Twenty-one patients were seen. The median age was 3 years (2 days–13 years). The mean duration of symptoms before presentation was 2.6 years. Nineteen patients (91%) presented with urosepsis while 8 patients (36%) presented with significant renal insufficiency. Laboratory findings varied from-mild-to marked elevation in serum creatinine. Radiological findings confirmed the diagnosis of posterior urethral valve. We concluded that late presentation is common in our setting. This is associated with high morbidity and mortality rates. Efforts at improving awareness and early diagnosis among the health team should be made to stem the tide.

Risk Factors Associated With Chronic Kidney Disease in Patients With Posterior Urethral Valves Without Prenatal Hydronephrosis

Postnatal diagnosis of posterior urethral valves continues despite the prevalence of prenatal ultrasound. We identified risk factors associated with chronic kidney disease in these children. We retrospectively reviewed the medical records of boys with posterior urethral valves with clinical presentations other than prenatal hydronephrosis. We recorded presenting symptoms, age at presentation, and preoperative hydronephrosis and/or vesicoureteral reflux. Chronic kidney disease was defined as previous renal transplantation, dialysis dependence or glomerular filtration rate less than 60 ml per minute/1.73 m(2) at last followup. We used univariate survival analysis with the log rank test of equality for categorical variables and Cox proportional hazard regression for continuous variables to identify risk factors associated with progression to chronic kidney disease. We identified 141 boys with posterior urethral valves with a postnatal presentation. Median age at presentation was 46 months (range 0.3 to 174). Febrile urinary tract infection in 28% of patients and voiding complaints in 50% were the most common presentations. A total of 12 patients (9%) progressed to chronic kidney disease up to 23 years after initial presentation. Preoperative bilateral hydronephrosis, increased hydronephrosis severity and bilateral vesicoureteral reflux were associated with progression to chronic kidney disease. Approximately 10% of cases with postnatal presentation of posterior urethral valves progress to chronic kidney disease, sometimes decades after the initial presentations. Although all patients with posterior urethral valves should be counseled on the potential loss of renal function, children with risk factors warrant close followup into adulthood.

Lower abdominal mass in a 16-year old adolescent: an unusual presentation of posterior urethral valves

Posterior urethral valves (PUV) are now commonly suspected on antenatal ultrasound, but can present with a broad spectrum of severity postnatally. Rarely, the diagnosis is missed until adolescence or adulthood when the patient usually presents with lower urinary tract symptoms. We describe an even rarer case of PUV in an adolescent who first presented with renal failure and a palpable lower abdominal mass due to urinary retention. We review the literature on presentation, natural history and outcomes of both early and late presenting PUV cases.

Urinomas protect renal function in posterior urethral valves—a population based study

Background/Purpose Urinomas have been thought to protect renal function in boys with posterior urethral valves (PUVs), although recent reports have disputed this. This study tested the hypothesis that urinomas protect global renal function in boys with PUV. Methods A retrospective analysis of all boys with PUV presenting to a tertiary unit derived from a region with an estimated population of 5.5 million was performed. Comparisons of the initial nadir creatinine, current creatinine, and renal status score (RSS) were made between those with and without urinomas. The RSS was derived from nephrology assessment of current renal status (0 = normal to 4 = end-stage renal failure or transplantation). Results were given as median (range), except for RSS, which was given as mean ± SEM. P ≤ .05 was regarded as significant. Results During 1989-2009, 9 of 89 PUV boys were diagnosed with urinomas. Initial nadir creatinine was statistically lower in boys with urinomas (31 [18-44] vs 45 [20-574] μmol/L, P < .01). Length of follow-up was similar (5.1 [2.2-17.3] vs 5.9 [1.8-19.7] years, P = .59). Follow-up creatinine was significantly lower in urinoma boys (44 [25-77] vs 61 [29-1227] μmol/L, P < .05), as was the RSS (0.14 ± 0.14 vs 0.91 ± 0.14, P < .01). No urinoma boys progressed to end-stage renal failure or required transplant. Conclusion This population-based study of PUV boys demonstrates that urinomas reduce nadir creatinine and significantly protect long-term global renal function.

Posterior Urethral Valves (PUV): Prenatal Ultrasound Findings and their Correlation with Glomerular Filtration Rate (GFR) at I Year of Age

PURPOSE The prognostic value of prenatal ultrasound in boys with PUV is controversial, especially in those with normal amniotic fluid (AF) volumes. This study correlates the prenatal status with the outcome of renal function at age 1-year. MATERIAL AND METHODS 50 unselected boys with PUV presenting to our unit, 30 with a prenatal history at one of two referring fetal medicine units are included in the analysis. GFR (Cr51 EDTA C-slope clearance ml/min/1.73 m 2) at 1-year of age was correlated with amniotic fluid volume (AF; n=25) and with the status of pre-natal renal cortical echogenecity (n=18). GFR results were classified into 3 groups; Normal (>80mls/min/1. 73m 2), Impaired (30 – 80 ml/min/1.73 m 2) and End Stage Renal Disease (ESRD) (<30ml/min/1.73 m 2). ANOVA single factor statistical analysis was used. RESULTS Prenatal detection did not affect the outcome of GFR compared with post-natal presentation only (means 71.73 v 71.5 respectively). Normal AF was associated with a better GFR compared with reduced AF (86 v 30; P < 0.001), all those with reduced AF had a low GFR. Normal AF did not always correlate with a normal GFR; 8/19 had impaired renal function. Prenatal bilateral echogenic kidneys were associated with a poor GFR outcome compared to normal and unilateral echogenic kidneys (P=0.005). CONCLUSIONS “Normal” AF with PUV obstruction does not predict a normal GFR at 1-year of age. Pre-natal bilateral echogenic kidneys and reduced AF are associated with a poor renal outcome at age 1-year. A “Normal” ultrasound at 20 weeks gestation does not exclude PUV obstruction.

Delayed Presentation in Posterior Urethral Valve: Long-Term Implications and Outcome

To analyze the effect of delayed presentation of posterior urethral valves in children. We divided 194 children with posterior urethral valve (PUV) who underwent surgical ablation into group I (less than 2 years old) and group II (greater than 2 years old) according to age at presentation. We analyzed the data for the effect of various parameters on post-valve fulguration long-term outcomes. Groups I and II had 95 and 99 children, respectively. Poor urinary stream or crying during micturition was the most common presenting complaint (96%) in both groups. A total of 32.6% and 81.8% patients had azotaemia at the time of diagnosis in groups I and II, respectively (P <0.001). Mean serum creatinine was 1.68 mg% and 4.1 mg% in groups I and II, respectively (P <0.05). Primary valve ablation was performed in 85.5% patients. After valve ablation, voiding improved in 86.1% and 20.4% patients in groups I and II, respectively (P = 0.001). At a mean follow-up of 9.8 years, 30.5% and 40.8% patients developed renal insufficiency in groups I and II, respectively (P <0.05). Serum creatinine level at 1 year after valve ablation and at presentation was the main prognostic factor for groups I and II, respectively, whereas persistence of VUR and voiding dysfunction after valve ablation reflected poor prognosis for both groups. Patients with PUV presenting after 2 years should be treated with caution because the condition is potentially hazardous and these patients are at a higher risk of developing chronic renal insufficiency on long-term follow-up.

The Impact of Late Presentation of Posterior Urethral Valves on Bladder and Renal Function

We retrospectively reviewed the records of patients with late presentation of PUVs, and compared bladder and renal function to that in patients with an early diagnosis of PUVs. We retrospectively reviewed the charts of 36 males (mean age at diagnosis 8.8 years, range 5 to 14) with late presentation of PUVs who were treated at our institution between 1986 and 2004. Of these patients 20 had undergone urodynamic evaluation during followup (mean age 10.65 years, range 5 to 23). We chose as controls 19 age matched children with PUVs who were diagnosed and treated before age 5 years and underwent urodynamic evaluation during followup (mean age at urodynamic evaluation 8.52 years, range 6 to 15). Urodynamic parameters were compared between the 2 patient groups. Renal function in the late presenting cases was also compared to controls. The most common symptoms at presentation were diurnal enuresis (17 patients, 47.2%) poor stream (7, 19.4%) and urinary retention (5, 13.9%). Overall, urodynamic bladder abnormalities were detected in 17 of 20 patients (85%), detrusor overactivity in 3 (15%), significant post-void residual in 9 (45%) and bladder capacity greater than expected for age in 9 (45%). No significant difference in bladder capacity, compliance or post-void residual was demonstrated between the late presenting and control groups. Only detrusor overactivity was significantly lower in the late presenting group (p = 0.013). After a mean followup of 67.03 months age specific creatinine levels were increased in 13 of 27 patients (48.1%), including 7 (25.9%) with ESRD. Renal function was significantly impaired in the late presenting group compared to controls (48.1% vs 13.7%, p = 0.001). We found a significantly lower rate of detrusor overactivity (15%) in patients with late presenting PUVs. Comparison of urodynamic parameters between the early and late presenting groups did not reveal any significant difference. This similar pattern of bladder dysfunction, independent of age at relief of obstruction, may indicate a common pathophysiological etiology for bladder dysfunction in all patients with PUVs. Also, renal function was significantly impaired in the late presenting group in this series.

Reply by the authors

We thank Dr. Walker for these comments, and we would like to clarify a few points. We disagree with the tighter definition of PUV, because the diagnosis of this entity is not always associated with elevated creatinine or hydronephrosis. Also, this tighter definition could account for the discrepancy between our results and that of Bomalski et al1 Bomalski DM, Anema JG, Coplen DE, et al: Delayed presentation of posterior urethral valves: a not so benign condition. J Urol 162: 2130–2132, 1999. Google Scholar (30% versus 71%). Although the controversy about “minimal” valves continues, we did not address this issue in our report.

DELAYED PRESENTATION OF POSTERIOR URETHRAL VALVES: A NOT SO BENIGN CONDITION

Posterior urethral valves are usually detected during infancy by prenatal sonography. Rarely they may be diagnosed during later childhood, adolescence or even adulthood. Less is known about presentation and outcome in these older patients. We reviewed our experience at 4 institutions with the late presentation of posterior urethral valves. A 13-year retrospective review revealed the late presentation of posterior urethral valves in 47 patients 5 to 35 years old (mean age 8). Data collected included presenting symptomatology, radiographic findings and renal function. Statistical analysis determined the relationships among presenting symptoms, patient age at diagnosis and renal function. The most common presenting symptoms were diurnal enuresis in 60% of the cases, urinary tract infection in 40% and voiding pain in 13%. Other presenting symptoms in less than 10% of the cases included poor stream, gross hematuria and proteinuria. At diagnosis hydronephrosis and vesicoureteral reflux were present in 40 and 33% of the patients, respectively, while serum creatinine was elevated in 35% and end stage renal disease had developed in 10%. The severity of presenting signs and symptoms was significantly associated with renal impairment, while patient age at diagnosis was not. Posterior urethral valves is not merely a disease of infancy. Voiding cystourethrography should be considered in boys older than 5 years who have voiding complaints, especially in association with diurnal enuresis or urinary tract infection. Patients who present late with posterior urethral valves are at risk for progression to end stage renal disease.

Posterior urethral valves after infancy-urodynamic consequences.

This study describes a subset of patients with posterior urethral valves (PUV) who presented late in childhood. The objective was to identify factors that lead to back-pressure effects on the upper tracts, which persist in spite of adequate valve ablation in some patients, and seek factors that may preserve the upper tracts despite untreated obstruction in other patients. Six children with PUV diagnosed after infancy were evaluated. The pre-operative work-up included renal biochemistry, ultrasonography, voiding cystourethrography, and uroflowmetry. Detailed urodynamic studies, including uroflowmetry and slow-fill cystometry, were performed in all cases 6 months after surgery. Adequacy of valve fulguration was confirmed by urethroscopy. Three of the six patients had normal upper tracts; in these, there was marked improvement in peak urine flow rates after fulguration and bladder pressures were normal. The other three patients had bilateral hydroureteronephrosis, and two had chronic renal failure. This group had markedly decreased functional bladder capacity with loss of compliance at low bladder volumes and significant residual urine volumes in spite of adequate valve fulguration, suggesting myogenic detrusor failure. We conclude that in patients with PUV presenting beyond the age of 5 years, upper-tract deterioration may accompany high storage pressures in the bladder. In some boys with long-standing obstruction the upper tracts may escape damage; in our series this was associated with normal bladder dynamics and appeared unrelated to the severity or duration of outflow obstruction.