Cat Scratch Disease Presenting Research Articles

Vague Presentation of Cat Scratch Disease in a Child

Vague Presentation of Cat Scratch Disease in a Child

Cat-scratch disease manifesting as uveitis and binocular fundus nodular lesions: a case report

BackgroundCat-scratch disease typically presents with various ocular manifestations such as uveitis, vitritis, retinitis, retinochoroiditis, and optic neuritis. However, fundus nodular lesions was rarely reported. In our study, we reported a case of Cat-Scratch disease with binocular fundus nodular lesions.Case presentationAn 11-year old male presented with uveitis in the right eye and bilateral fundus nodular lesions after indirect contact with unvaccinated cats. Comprehensive ancillary examinations including wide-angle fundus photography, ultrasonography, fluorescein fundus angiography, optical coherence tomography, and orbital magnetic resonance imaging were performed to elucidate the multidimensional features of the binocular lesions. Metagenomics next-generation sequencing was utilized to confirm the diagnosis of Cat-scratch disease. The patient’s condition showed improvement after a 6-month combination treatment regimen involving systemic administration of doxycycline hyclate and methylprednisolone tablets, as well as local application of mydriatic and corticosteroid eye drops.ConclusionsWe firstly reported a case of Cat-scratch disease presenting simultaneously with uveitis and fundus nodular lesions caused by Bartonella henselae infection in a child. Timely diagnosis and treatment with antibiotics and corticosteroids showed promising outcomes for the prognosis of these ocular disorders.

Cat Scratch Disease Presenting as Fever of Unknown Origin in a Hemodialysis Patient with Autosomal Dominant Polycystic Kidney Disease

Cat Scratch Disease Presenting as Fever of Unknown Origin in a Hemodialysis Patient with Autosomal Dominant Polycystic Kidney Disease

Mystery Rash: Atypical Presentation of Suspected Cat-Scratch Disease in Primary Care

Mystery Rash: Atypical Presentation of Suspected Cat-Scratch Disease in Primary Care

A Rare Presentation of Cat-Scratch Disease: A Case Report with Neuroretinitis and Review of Cases Reported from Turkey

Neuroretinitis is a rare presentation of cat-scratch disease caused by Bartonella henselae. In this case report, we aimed to describe a 46-year-old male patient who presented with acute visual loss and was diagnosed as neuroretinitis. Fundus examination showed evidence of optic disc edema, macular star, and peripapillary hemorrhagia. The serological tests were positive for Bartonella with both IgM and IgG titers as 1/320. He was successfully treated with doxycycline for eight weeks. Both clinical and serological improvements were observed during the follow-up. Keywords : neuroretinitis, Bartonella henselae, cat-scratch diseases

Cat-Scratch Disease Presenting as Fever of Unknown Origin

Cat-Scratch Disease Presenting as Fever of Unknown Origin

Cat-Scratch Disease Presenting as a Popliteal Mass

Cat-Scratch Disease Presenting as a Popliteal Mass

Case report on Parinaud’s oculoglandular syndrome; a presentation of cat scratch disease

Cat scratch disease is an infectious disease caused by Bartonella species. Usually a self-limited illness, cat-scratch disease rarely gets reported. This case report describes about a patient admitted with clinical features of Parinaud’s oculoglandular syndrome – an atypical clinical presentation cat scratch fever - which was treated successfully with antibiotics.

Cat-Scratch Disease Pneumonia: An Atypical Presentation

Purpose: Cat-scratch disease is caused by Bartonella henselae infection and it commonly presents in children with a mild cutaneous lesion and adjacent lymphadenitis. It has rarely been observed that it can present as a disseminated infection, such as encephalitis or pneumonia. We present a case report of a 35-year old, immunocompetent, patient who suffered pneumonia and encephalitis, resulting from Bartonella henselae infection. We also present a review of the literature published regarding this rare complication.
 Methods: We’ve searched the literature in the databases of Pubmed and Google Scholar to find articles that report pulmonary presentations of cat-scratch disease.
 Results: We’ve found only 16 other reported similar cases with pulmonary involvement in cat-scratch disease.
 Conclusions: Pulmonary presentation in cat-scratch disease is an uncommon presentation of a common disease, and it should be ruled out, even in cases it seems unlikely.

Pediatric Bartonella Infection (Cat Scratch Disease) Presenting as Inguinal Lymphadenopathy

Cat scratch disease is an infectious disease resulting from inoculation of Bartonella species through a cat scratch or bite, often presenting as an erythematous papule at the site of inoculation with nearby painful lymphadenopathy. The diagnosis of this disease is complicated by a wide variety of clinical presentations, as the primary lesion may not be initially noticed. Furthermore, cervical and axillary lymph nodes are the most commonly involved regions of tender lymphadenopathy, but there have been reported cases that do not fit the typical clinical picture – such the case discussed in this report of a pediatric Bartonella henselae infection that initially presented as left inguinal lymphadenopathy with underlying necrosis and abscess formation. In this case, a 9-year-old boy presented to the ED with a 4-day history of increasing mass in the left groin, as well as a subjective fever for the previous 2 days. An ultrasound revealed a necrotic abscess in the left inguinal lymph node which necessitated empiric antibiotic therapy and surgical excision; titers revealed a recent infection with Bartonella henselae. Atypical presentations of cat scratch disease, such as inguinal lymphadenopathy, have historically confounded the diagnosis. However, positive serology studies ultimately yielded the correct diagnoses in these children. Given that cat scratch disease can present in an atypical fashion in approximately 5 - 25% of cases, physicians should keep the disease on the differential even when presented with rare presentations such as inguinal lymphadenopathy; serological testing for B. henselae can be utilized once more likely etiologies have been ruled out.

Cat-Scratch Disease in a Child with Ocular Involving: A Case Report

We report a case of a 10-year-old child, who presented with headache, nausea and fever in the past 72 hours. Past medical history was insignificant; parents did not signal any helpful information. Laboratory tests and radiology imaging were normal except for high inflammatory indices and modest spleen enlargement. Rotavirus infection was isolated from the blood cultures. We want to describe this unusual case of cat-scratch disease presenting with soft mono-lateral optic nerve involvements without the typical scratch related regional lymphadenopathy in order to highlight the heterogeneous presentation of Bartonella Henselae infection, especially in children. Therefore, we should consider cat-scratch disease in any patients with FUO and unspecific systemic symptoms even if there is not a recent cat relate contact and a typical clinical presentation.

2311. Atypical Cat Scratch Disease Presentations

BackgroundCat scratch disease (CSD) is caused by B henselae, a Gram-negative intracellular bacilli which is transmitted to humans via cat bite/scratch. Typical CSD presents as regional lymphadenopathy and fever. However, there are multiple atypical presentations of cat scratch disease that have been reported including prolonged fever, absence of lymphadenopathy and systemic complications such hepatosplenic disease, osteomyelitis, Parinaud oculoglandular syndrome, neuroretinitis, encephalitis, and bacillary angiomatosis among other rare presentations. The aim of this study was to review the frequency, presentation, and treatment outcomes of aytpical CSD presentations at Nationwide Children’s Hospital (Columbus OH).MethodsThis was a retrospective study performed at Nationwide Children’s Hospital, Columbus, OH. EMR of patients were reviewed between January 2010 and March 2017 using ICD9 or ICD 10 codes for CSD. Patients were identified on the basis of compatible clinical presentation and confirmatory serological test or PCR results for B. henselae. Clinical, radiological, and histopathological findings were collectedResultsA total of 204 patients were serologically diagnosed as having cat scratch disease between January 2010 and July 2017. Of the 204 cases, 166 (81%) had typical CSD and 38 (18.6%) had atypical CSD. Of the atypical manifestations, 20 (52%) patients had no lymphadenopathy, 12 (31%) had osteomyelitis, 12 (31%) patients had hepatic and/or splenic microabscesses, 4 (10.5%) had osteomyelitis and hepatic/splenic involvement, 3 (1.5%) had encephalitis, 2 (5.2%) had neuroretinitis, and there was one case each (2.6%) of Parinaud oculoglandular syndrome, uveitis, pulmonary cavitary lesion, myocarditis, and endocarditis. Fever of unknown origin was present in 28 (75.6%) of the atypical CSD cases. The median duration of antibiotic treatment was 25 days (IQR 31) and median duration of illness in patients with atypical CSD was 51 days (IQR 56). The majority of patients were treated with dual antibiotic therapy that included rifampin.ConclusionIn children with fever of unknown origin, serologic testing for CSD should be performed even in the absence of lymphadenopathy and a search for underlying systemic complications is recommended for prompt diagnosis and appropriate treatment.Disclosures All authors: No reported disclosures.

A Rare Case of Cat-Scratch Disease Presenting as Axillary Lymphadenopathy with Non Tuberculous Mycobacterial Infection

A Rare Case of Cat-Scratch Disease Presenting as Axillary Lymphadenopathy with Non Tuberculous Mycobacterial Infection

Cat Scratch Disease Presenting as Isolated Neck Torticollis

Cat Scratch Disease Presenting as Isolated Neck Torticollis

Chorioretinitis as a Rare Presentation of Cat Scratch Disease: A Case Report

Chorioretinitis as a Rare Presentation of Cat Scratch Disease: A Case Report

Atypical presentation of cat-scratch disease in an immunocompetent child with serological and pathological evidence.

Typical cat-scratch disease (CSD) is characterized by local lymphadenopathy following the scratch or bite from a cat or kitten. An atypical presentation which includes liver and/or spleen lesions is rarely reported in an immunocompetent child. Systemic CSD may mimic more serious disorders like malignancy or tuberculosis. Although a diagnosis is difficult to establish in systemic CSD, an early diagnosis and an appropriate treatment are important to prevent complications. Bartonella henselae is difficult to culture, and culture is not routinely recommended. Clinical, serological, radiological, and pathological findings are used for the diagnosis of CSD. Herein we present a case of systemic CSD presenting with hepatic mass in an immunocompetent child. The differential diagnosis is made by serological and pathological evidence. He was successfully treated with gentamicin (7.5 mg/kg) and rifampin (15 mg/kg) for six weeks.

A star in the eye: cat scratch neuroretinitis.

Key Clinical MessageNeuroretinitis is one of the atypical presentations of Cat scratch disease (CSD). Fundoscopy showed star pattern macular exudates. CSD should be considered in patients who present with blurry vision and typical fundoscopic findings.

Présentation cutanée atypique d’une maladie des griffes du chat

Herein we report a case of cat scratch disease on account of its atypical presentation.A 21-year-old woman presented erythema nodosum associated with painful bilateral inguinal adenopathy, odynophagia, joint pain and evening urticaria in a setting of impaired general condition. Initial serological testing for Bartonella henselae was negative. PCR for Bartonella henselae performed on an adenectomy fragment was positive. A favourable outcome was achieved with azithromycin.This case shows an atypical and severe presentation of cat scratch disease and raises the problem of sensitivity of serotyping.

Pediatric Neck Masses

Pediatric Neck Masses

Cat Scratch Disease Presenting as Breast Cancer: A Report of an Unusual Case

Benign lymphoreticulosis (cat scratch disease, CSD) may have a clinical course that varies from the most common lymphadenitis localized in the site of inoculation, preceded by the typical “primary lesion,” to a context of severe systemic involvement. Among these uncommon clinical aspects, there is mammarian granulomatous lymphadenitis which may appear as a mastitis or a solitary intraparenchymal mass, giving the impression of a breast tumor. In these cases, intensive clinical, instrumental, and laboratory investigations are necessary to exclude malignancy. Because of its rarity, in equivocal cases, it is reasonable to use surgical excision for accurate histological examination. We report a case of CSD of the breast in a 59-year-old woman, analyzing the clinical, histopathological, and instrumental appearance and also performing a literature review.