Presentation Of Anaplastic Thyroid Carcinoma Research Articles

Anaplastic Thyroid Carcinoma Mimicking Cervical Tuberculosis: A Case Report.

Anaplastic thyroid carcinoma is a rare and aggressive form of thyroid cancer that has a poor prognosis and a high mortality rate. It is characterized by rapid growth and invasion of nearby tissues. It typically presents as a rapidly growing goiter or nodule that is firm to the touch and firmly attached to the underlying structures. Case reports of unusual presentations of anaplastic thyroid carcinoma have been reported. The presentation of anaplastic thyroid carcinoma mimicking cervical tuberculosis is very unusual. We reported a case of a 65-year-old patient who had a left cervical swelling that had been evolving for 4 months, causing dysphagia. Initial imaging showed a necrotic mass in the left lobe of the thyroid, communicating with a second necrotic mass in the subcutaneous tissue that was fistulized to the skin and suggesting cervical tuberculosis. The mass was incised with pus and whitish material resembling caseous tuberculosis was discharged. Acid-fast bacilli (AFB) Polymerase chain reaction (PCR) was negative and biopsy revealed a nonspecific granulomatous lesion. Due to the growth of the mass and the presence of a permeation nodule, a second biopsy was performed, revealing anaplastic thyroid carcinoma. The patient was referred for radiochemotherapy due to tumor inoperability.

Rising incidence of malignancy in thyroid nodule: a clinico radio pathological evaluation

Background: Thyroid nodules are a common endocrine problem with varied aetiology and presentation. Benign nodules also need to be evaluated in detail for possibility of malignancy in today’s era of rising incidence of malignancy. This study aims to comparatively analyse and verify the incidence of malignancy reported in tertiary care hospital with incidence of malignancy published in standard journals and research. The study also endeavours to clinically examine solitary thyroid nodules in patients admitted to the tertiary care centre. Methods: A retrospective study was carried out from 2019 to 2022, in the Department of ENT, in a Tertiary Care Hospital. Thirty patients, with solitary thyroid nodule, were clinically examined and investigated using ultrasonography and Fine Needle Aspiration Cytology, before undergoing hemi/total thyroidectomy. The histopathological reports and pre-operative investigations were analysed by standard statistical methods. Results: Clinically detected solitary thyroid nodule turned out to be malignant in 30% of studied cases with preponderance of papillary carcinoma. This figure is significantly higher than most of the previous data published in standard journals. A rare case of cystic presentation of anaplastic thyroid carcinoma was also studied. Conclusions: It is concluded from the present study that incidence of malignancy has shown sharp rise- from the published average of 19-21 percent to 30 percent in the present case. The study also infers that there is female preponderance in thyroid swellings. The mean age of solitary thyroid nodule is 35 years i.e., between 30 to 40 years.

Unusual presentation of anaplastic thyroid carcinoma with diffuse neck and thoracic nodules and hyperthyroidism

Abstract Anaplastic thyroid carcinoma (ATC) is a highly aggressive endocrine tumor that can be expected to have a poor clinical outcome. Cutaneous metastases from ATC are rare and in the context of disseminated metastases. Owing to the rarity of the disease, no standard treatment has been documented, and few treatment modalities are effective. This case reports neck and thoracic cutaneous metastasis from ATC, with concurrent hyperthyroidism.

A rare presentation of anaplastic thyroid carcinoma: spontaneous intrathyroidal hemorrhage

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Laryngotracheal presentation of anaplastic thyroid carcinoma with squamous differentiation: seven cases demonstrating an under‐recognized diagnostic pitfall

To describe a series of anaplastic thyroid carcinomas that mimicked primary head and neck squamous cell carcinoma (HNSCC) by virtue of both morphology and clinical presentation. Seven cases were identified in a 15-year period where a biopsy of an airway lesion that appeared to be squamous cell carcinoma was, in fact, anaplastic thyroid carcinoma. The tumours had squamous and/or spindle cell morphology, with only the squamous component being apparent in the airway biopsy. Some tumours arose within metaplastic (n=3) or atypical (n=3) epithelium, supporting the diagnosis of a primary mucosal tumour. Positive PAX8 (n=5) and TTF-1 (n=4) staining was identified. An endotracheal presentation of anaplastic thyroid carcinoma with squamous morphology may be misdiagnosed as a primary head and neck squamous cell carcinoma. PAX8 and TTF-1 expression are helpful in making the distinction, but the problem lies in suspecting a thyroid carcinoma in what appears to be a straightforward diagnosis of HNSCC.

Anaplastic thyroid carcinoma presenting as bilateral pleural effusion.

Anaplastic thyroid cancer presenting as bilateral malignant pleural effusion is rarely reported. We present a case who presented solely with respiratory symptoms and subsequently found to be having bilateral malignant pleural effusion secondary to anaplastic thyroid cancer.

Ventricular Thrombus and Thrombocytopenia As First Presentation of Anaplastic Thyroid Carcinoma

Ventricular Thrombus and Thrombocytopenia As First Presentation of Anaplastic Thyroid Carcinoma

Emergency total thyroidectomy for bleeding anaplastic thyroid carcinoma: A viable option for palliation

Anaplastic thyroid carcinoma (ATC) is a rare and highly aggressive thyroid neoplasm. Bleeding from tumor is an uncommon, but potentially life-threatening complication requiring sophisticated intervention facilities which are not usually available at odd hours in emergency. We report the case of a 45-year-old woman who presented with exsanguinating hemorrhage from ATC and was treated by emergency total thyroidectomy. The patient is well three months postoperatively. Emergency total thyroidectomy is a viable option for palliation in ATC presenting with bleeding.

Superior Vena Cava Syndrome: A Presentation of Anaplastic Thyroid Carcinoma

Superior Vena Cava Syndrome: A Presentation of Anaplastic Thyroid Carcinoma

Anaplastic thyroid cancer presenting with hyperthyroidism

Primary thyroid malignancies typically do not interfere with thyroid function. A patient is reported with anaplastic thyroid carcinoma presenting with hyperthyroidism; this is believed to be the first such case described. Prior to the onset of the thyroidal process, the patient was clinically euthyroid. It is concluded that the mechanism of thyrotoxicosis is analogous to that of subacute thyroiditis: rapid tissue necrosis with resultant release of thyroid hormone.