Present Day Research Articles

The environment and the internal clocks: The study of their relationships from prehistoric to modern times.

The origin of biological rhythms goes back to the very beginning of life. They are observed in the animal and plant world at all levels of organization, from cells to ecosystems. As early as the 18th century, plant scientists were the first to explain the relationship between flowering cycles and environmental cycles, emphasizing the importance of daily light-dark cycles and the seasons. Our temporal structure is controlled by external and internal rhythmic signals. Light is the main synchronizer of the circadian system, as daily exposure to light entrains our clock over 24 hours, the endogenous period of the circadian system being close to, but not exactly, 24 hours. In 1960, a seminal scientific meeting, the Cold Spring Harbor Symposium on Biological Rhythms, brought together all the biological rhythms scientists of the time, a number of whom are considered the founders of modern chronobiology. All aspects of biological rhythms were addressed, from the properties of circadian rhythms to their practical and ecological aspects. Birth of chronobiology dates from this period, with the definition of its vocabulary and specificities in metabolism, photoperiodism, animal physiology, etc. At around the same time, and right up to the present day, research has focused on melatonin, the circadian neurohormone of the pineal gland, with data on its pattern, metabolism, control by light and clinical applications. However, light has a double face, as it has positive effects as a circadian clock entraining agent, but also deleterious effects, as it can lead to chronodisruption when exposed chronically at night, which can increase the risk of cancer and other diseases. Finally, research over the past few decades has unraveled the anatomical location of circadian clocks and their cellular and molecular mechanisms. This recent research has in turn allowed us to explain how circadian rhythms control physiology and health.

Variability in the prevalence of inappropriate medication use among older adults: A review highlighting the importance of screening methods and database types.

The global older population is growing rapidly, and the rise in polypharmacy has increased potentially inappropriate medication (PIM) encounters. PIMs pose health risks, but detecting them automatically in large medical databases is complex. This review aimed to uncover PIM prevalence in individuals aged 65 years or older using health databases and emphasized the risk of underestimating PIM prevalence due to underutilization of detection tools. This study conducted a broad search on the Medline database to identify articles about the prevalence of PIMs in older adults using various databases. Articles published between January 2010 and June 2023 were included, and specific criteria were applied for study selection. Two literature reviews conducted before our study period were integrated to obtain a perspective from the 1990s to the present day. The selected papers were analysed for variables including database type, screening method, adaptations and PIM prevalence. The study categorized databases and original screening tools for clarity, examined adaptations and assessed concordance among different screening methods. This study encompassed 48 manuscripts, covering 58 sample evaluations. The mean prevalence of PIMs within the general population aged over 65 years was 27.8%. Relevant heterogeneity emerged in both the utilized databases and the detection methods. Adaptation of original screening tools was observed in 86.2% (50/58) of cases. Half of the original screening tools used for assessing PIMs belonged to the simple category. About a third of the studies employed less than half of the original criteria after adaptation. Only three studies used over 75% of the original criteria and more than 50 criteria. This extensive review highlights PIM prevalence among the older adults, emphasizing method intricacies and the potential for underestimation due to data limitations and algorithm adjustments. The findings call for enhanced methodologies, transparent algorithms and a deeper understanding of intricate rules' impact on public health implications.

Turning points in the practice of liver surgery: A historical review.

The history of liver surgery is a tale of progressive resolution of issues presenting one after another from ancient times to the present days when dealing with liver ailments. The perfect knowledge of human liver anatomy and physiology and the development of a proper liver resective surgery require time and huge efforts and, mostly, the study and research of giants of their own times, whose names are forever associated with anatomical landmarks, thorough descriptions, and surgical approaches. The control of parenchymal bleeding after trauma and during resection is the second issue that surgeons have to resolve. A good knowledge of intra and extrahepatic vascular anatomy is a necessary condition to develop techniques of vascular control, paving the way to liver transplantation. Last but not least, the issue of residual liver function after resection requires advanced techniques of volume redistribution through redirection of blood inflow. These are the same problems any young surgeon would face when approaching liver surgery for the first time. Therefore, obtaining a wide picture of historical evolution of liver surgery could be a great starting point to serve as an example and a guide.

ICRH operations during the JET tritium and DTE2 campaigns

The JET-ILW pure tritium and deuterium–tritium (DTE2) experimental campaigns took place in 2021–2022. Tritium (T) and deuterium–tritium (D–T) operations present challenges not encountered in present day tokamaks (Horton et al 2016 Fusion Eng. Des. 109–111 925–36). This contribution focuses on ion cyclotron resonance heating (ICRH) operations in tritium and deuterium–tritium plasmas, starting with a summary of the program of improvements to the ICRH system which spanned a few years prior to these experiments. Procedures were implemented to address specific constraints from tritium and deuterium–tritium operations (tritium safety and reduced access to the RF generator area) and increase the system reliability and power availability during plasma pulses. Operation of the upgraded real time RF power control system that maximises the launched power while taking into account limitations from the system or antenna coupling is described. We also report on the result from dedicated pulses performed to assess the potential harmful impact of the 2nd harmonic tritium resonance in the plasma, close to the inner wall, when using the standard central hydrogen minority ICRH scheme. During DTE2, the ITER-like antenna was not used because water leaked from an in-vessel capacitor into the vessel on day-2 of the experimental campaign. The lessons learnt from this incident are highlighted. Finally, the ICRH plant adjustments required to safely perform ion cyclotron wall cleaning discharges are described.

Mechanisms of global ocean ventilation age change during the last deglaciation

Abstract. Marine radiocarbon (14C) is widely used to trace deep-ocean circulation, providing insight into the atmosphere–ocean exchange of CO2 during the last deglaciation. Evidence shows a significantly depleted Δ14C in the glacial deep ocean, suggesting an increased ventilation age at the Last Glacial Maximum (LGM). In this study, using two transient simulations with tracers of 14C and ideal age (IAGE), we found that the oldest ventilation age is not observed at the LGM. In contrast, the models show a modestly younger ventilation age during the LGM compared to the present day. The global mean ventilation ages averaged below 1 km are approximately 800 (630) years and 930 (2000) years at the LGM and in the present day, respectively, in two simulations. This younger glacial ventilation age is mainly caused by the stronger glacial Antarctic Bottom Water (AABW) transport associated with sea ice expansion. Notably, the ocean ventilation age is significantly older predominantly in the deep Pacific during deglaciation compared to the age at the LGM, with global mean ventilation ages peaking at 1900 and 2200 years around 14–12 ka in two simulations, primarily due to the weakening of AABW transport.

Magnetic Field Effect on Photocatalytic Dye Degradation: A Review

AbstractIn the present day, photocatalysis has become the primary and most promising technology to generate renewable energy and degrade environmental pollutants. Remarkable efforts have been made to improve photocatalytic efficiency. Among these, introducing an external magnetic field is considered a promising strategy to boost photocatalytic performance. This review explores the dynamic realm of improving photocatalytic efficiency, with a particular emphasis on the strategic integration of external magnetic fields. Examining recent breakthroughs, we reviewed the influence of magnetic fields on diverse catalyst materials, including both magnetic and nonmagnetic variants, 2D materials, and semiconductors. Comprehensive coverage is provided on the mechanisms governing photocatalytic dye degradation, materials utilized for catalysis, and the profound impact of magnetic fields on enhancing reaction kinetics. This review also focuses on recent advances in the application and effect of magnetic fields in the magnetic and nonmagnetic catalysts towards dye degradation. This review provides a forward‐looking view, highlighting the potential of magnetic field‐enhanced photocatalysis to play a central role in sustainable energy and environmental management.

Farewell to the Young: Early Iron Age Mortuary Practices in the Middle Danube Region

ABSTRACT The study of burials and mortuary practices in the past provides essential information on the role and treatment of children in past communities. This study aims to better understand the status of children by reviewing the material culture provided by child burial contexts. Early Iron Age (800–300 BC) mortuary practices in the southern Middle Danube (present–day eastern Croatia and northwestern Serbia) are characterized mostly by the cremation of the dead. The Iron Age is an important time for funerary transitions. The standard practice of cremating the dead was replaced by the practice of inhumation during the 6th century BC. The manner of treatment of the dead body affected the preservation of objects and data in the graves. This paper studies 74 burials with child remains, costumes, jewellery, tool items, and pottery grave goods. In Early Iron Age mortuary practices, children were treated just like the adult members of the community.

Fifty Shades of Phenanthroline: Synthesis Strategies to Functionalize 1,10-Phenanthroline in All Positions.

1,10-Phenanthroline (phen) is one of the most popular ligands ever used in coordination chemistry due to its strong affinity for a wide range of metals with various oxidation states. Its polyaromatic structure provides robustness and rigidity, leading to intriguing features in numerous fields (luminescent coordination scaffolds, catalysis, supramolecular chemistry, sensors, theranostics, etc.). Importantly, phen offers eight distinct positions for functional groups to be attached, showcasing remarkable versatility for such a simple ligand. As a result, phen has become a landmark molecule for coordination chemists, serving as a must-use ligand and a versatile platform for designing polyfunctional arrays. The extensive use of substituted phenanthroline ligands with different metal ions has resulted in a diverse array of complexes tailored for numerous applications. For instance, these complexes have been utilized as sensitizers in dye-sensitized solar cells, as luminescent probes modified with antibodies for biomaterials, and in the creation of elegant supramolecular architectures like rotaxanes and catenanes, exemplified by Sauvage's Nobel Prize-winning work in 2016. In summary, phen has found applications in almost every facet of chemistry. An intriguing aspect of phen is the specific reactivity of each pair of carbon atoms ([2,9], [3,8], [4,7], and [5,6]), enabling the functionalization of each pair with different groups and leading to polyfunctional arrays. Furthermore, it is possible to differentiate each position in these pairs, resulting in non-symmetrical systems with tremendous versatility. In this Review, the authors aim to compile and categorize existing synthetic strategies for the stepwise polyfunctionalization of phen in various positions. This comprehensive toolbox will aid coordination chemists in designing virtually any polyfunctional ligand. The survey will encompass seminal work from the 1950s to the present day. The scope of the Review will be limited to 1,10-phenanthroline, excluding ligands with more intracyclic heteroatoms or fused aromatic cycles. Overall, the primary goal of this Review is to highlight both old and recent synthetic strategies that find applicability in the mentioned applications. By doing so, the authors hope to establish a first reference for phenanthroline synthesis, covering all possible positions on the backbone, and hope to inspire all concerned chemists to devise new strategies that have not yet been explored.

Histopathological study of lungs, kidney and spleen in death due to burns

Burn injuries occur universally and have plagued mankind ever since antiquity till the present day. As burns continue to be a major problem, a prospective study of demographic and pathological profile in deaths due to burns was conducted at the Department of Pathology Karnataka Institute of Medical Sciences Hubballi. To study the demographic profile, histopathological changes in lungs, kidney and spleen and to find the cause of death in cases due to burns. : The present study was carried out in the Department of Pathology, Karnataka institute of medical sciences, Hubballi, during the period of one year from 1-11-2014 to 31-10-2015. Total of 44 cases with burn injuries were used as material for study purpose and the collection of tissues were done for histopathology examination. This study includes 44 autopsy cases of death due to burn, of which majority were females. The age of the subjects ranged from 13 years to 65 years. Maximum numbers of victims were found in the age group of 21-30 years were 22 cases (50.00%).Most of the female victims were married and housewives. Most common manner of the burn were said accidental burns in 27 cases (61.36%) and 13 cases (29.54%) were due to suicidal burns, 4 cases (9.09%) were homicidal burns.Burns were more common in females most were married. Age group most commonly found was between 21-30 years of age probably related to dowry related issues, inexperience in cooking styles, house hold works, and inability to bear stress. Most common place of burns were kitchen. Most common manner of burns were said accidental. Most common cause of burns was due to said kerosene spill over or self pouring. TBSA involved more than 76%, in maximum number of cases. Maximum finding were seen in lung. Most common findings were diffuse alveolar damage, acute tubular injury and congested splenomegaly.

From public to market use: a historical perspective on the changes in health data collection and use in France from 1930 to the present

Purpose This study aims to understand the progressive marketization of health data collection and use, through a study of its historical development in France, from the 1930s to the present day. Design/methodology/approach The authors collected a set of legal, institutional, political and media data. These came from the INA (National Audiovisual Institute), the French national newspaper websites and the websites legifrance.gouv.fr and vie-publique.fr. The authors then conducted a thematic content analysis. Findings The study results highlight the changes in the health-care system related to the increased use of data in France over three major periods. The first period – 1930s to 1980s – is marked by the creation of the French social security system to collect large sets of data to better manager people’s health care. The second period – 1980s to 2000s – is characterized by the adoption and assimilation of tools to manage patient data through several national and European regulations. The last period – 2000s to the present – saw the introduction of measures in favor of the digitalization of health care, and consequently of data, in parallel with the advancement of digital technologies in general. The institutional dynamics in healthcare have evolved with the nature of the actors and their practices, in connection with new perceptions about health data. Originality/value This research sheds light on the historical transformation of health data collection and use in France, revealing the involvement of diverse stakeholders, the discourses driving data development and the need for regulation. It exposes the dual nature of health data collection and use, initially sanctioned by the state and public entities but later exploited for private interests.

The Changing Role of the Faculty of Military Leadership in Czech Military Education (2004–2018)

Educational mission of the Faculty of Military Leadership (until 2014 as Faculty of Economics and Management) of the University of Defence (Brno, Czech Republic) underwent since its origin in 2004 to 2018 number of changes. By analysing the structure of study programmes and the number of employees and students, the goal of this article is to identify the main periods in the development of the faculty as well as its role in the educational system. The results are as follows.The first period was a reaction to a process of professionalization of army, i.e., the replacement the conscript army by professionals that led into decrease of number of military students and parallel orientation towards civilian study programmes in national security. The second stage was influenced by the financial crisis of 2007–2008; that is why a gradual reduction of military study took place as well as serious considerations about the dissolution of the faculty and university, respectively. The third, final, period began in 2013–2014. Its main element was the change of characteristics of study programmes and their connection to the “militarization” of the faculty; reorganization of the structure of the faculty in 2014; the gradual increase of the number of military students at the expense of civilian students; and, finally, the cancelation of civilian study programmes. Year 2018, when personal changes in management of faculty took place together with a consideration about principles of a new study programme, could be regarded as the beginning of a qualitative new period in history of Faculty of Military Leadership that lasts until present day – and as such is out of focus of this study.

Addressing Barriers to Timely Orthopaedic Follow-up for Foot and Ankle Fractures After Emergency Department Visits.

Foot and ankle fractures present common challenges in emergency departments, warranting careful follow-up protocols for optimal patient outcomes. This study investigates the predictors of orthopaedic follow-up for these injuries after an emergency department (ED) visit. A retrospective observational study of 1450 patients seen in the ED with foot or ankle fractures from July 2015 to February 2023 was conducted. All included patients were discharged with instructions to follow-up with an orthopaedic provider. Demographic data, fracture details, and follow-up patterns were extracted from medical records. Social vulnerability was assessed using the Centers for Disease Control (CDC) Social Vulnerability Index. Univariate and multivariate analyses were performed to identify predictors of follow-up. A subgroup analysis comparing patients who followed up >7 days from ED presentation (ie, delayed follow-up) to those who followed up within 7 days of presentation was then performed. Statistical significance was assessed at P < .05. Overall, 974/1450 (67.2%) patients followed up with orthopaedics at an average time of 4.16 days. After risk adjustment, Medicaid coverage (odds ratio [OR] = 0.56, P = .018), increased overall social vulnerability (OR = 0.83, P = .032), and increased vulnerability across the dimensions of socioeconomic status (P = .002), household characteristics (P = .034), racial and ethnic minority status (P = .007), and household type and transportation (P = .032) were all associated with lower odds of follow-up. Phalangeal fractures were also associated with decreased odds of follow-up (OR = 0.039, P < .001), whereas ankle fractures were more likely to follow-up (OR = 1.52, P = .002). In the subgroup analysis, patients of older age (P = .008), non-white race (P = .024), motor vehicle accident (MVA) (P = .027) or non-private insurance (P = .027), those experiencing phalangeal fractures (P = .015), and those seen by an orthopaedic provider in the ED (P = .006) were more likely to present with delayed follow-up. Patients with increased social vulnerability and Medicaid insurance are less likely to seek follow-up care after presentation to the ED with foot and ankle fractures.

One Hundred and Thirty-Five Years of Ornithology in Bulgaria: The Role of the National Museum of Natural History at the Bulgarian Academy of Sciences in the Development of Ornithology in Bulgaria—Representatives, Collections and Achievements

For the first time, an attempt has been made to present, chronologically and in a systematized form, the development of ornithological studies at the National Museum of Natural History in Sofia (Bulgaria) from its foundation in the last decades of the 19th century to the present day. This 135-year period (1889–2024) includes the work of 12 curators of the ornithological collections. Their major contributions and most-significant ornithological publications are also presented.

A history of the McGill Department of Surgery: the first 100 years (1923-2023).

SummaryIn 1923, just over 100 years ago, Edward William Archibald was appointed the first chair of surgery in McGill University's Faculty of Medicine. This milestone provides an opportunity to reflect on where the department has come from and how it has progressed to the present day. Although the size, breadth, and diversity of the department members have changed notably over the century, the core values of innovative clinical care, research, and education established a century ago continue to this day. To reflect his values, the Archibald Chair of Surgery was established in 1990 and is today held by the department chair.

Laparoscopic modified e-tep repair of concomitant inguinal and ventral hernias.

Laparoscopic hernia repair in recent times has gained the most acceptance among both the surgical community and the patient groups, as it has proven benefits of lesser postoperative hospital stay and less pain scores. The incidence of both inguinal and ventral hernias has increased significantly in the present days. Various methods have been postulated by different surgical groups for repairing the same but no there is no standard consensus on managing concomitant inguinal and ventral hernias. The conventional e-TEP requires an extensive dissection with increased operative time. We present our experience in managing cases with both inguinal and primary M2/M3 and W1 ventral hernias with or without divarication of recti using a modified up to down approach for inguinal hernia followed by down to up approach for the ventral hernia, from a tertiary care center in South India. We managed 16 cases with simultaneous incidence of inguinal and primary M2/M3 and W1 ventral hernias with or without divarication of recti between January 2022 and November 2023. Institute ethical committee clearance and informed consent was obtained from all the 16 patients. They were all subjected to an extra peritoneal repair of both the hernias. All the demographic data, intraoperative data, postoperative complications and follow up were digitally stored. All patients were followed up for six months after surgery. Out of 16 patients, 15 were males and 1 was female. The mean age was 48years and the mean BMI of all the patients was 29.2kg/m2. The postoperative recovery was smooth in all patients and being discharged within 24h after surgery. The pain scores of all patients were significantly lower than patients who underwent intraperitoneal repair. e-TEP hernia repair is gaining popularity and has amused the hernia surgical community. Our method of e-TEP RS repair in cases with concomitant inguinal and primary M2/M3 W1 ventral hernias with or without divarication helps in addressing both the hernias in the extra-peritoneal space. Our technique reduces the area of dissection needed for mesh placement and preserves the integrity of abdominal musculature in the upper abdomen when compared with the conventional technique. It further allows extension of the e-TEP inguinal space into the Rectro rectus space without much alteration in the port arrangement allowing simultaneous repair of groin and umbilical hernias. Good knowledge of anatomy and laparoscopic skills are pertinent for safe and effective hernia repair by this technique.

The Use of Cultural Landscape Fragmentation for Rural Tourism Development in the Zemplín Geopark, Slovakia

This study outlines the creation of hiking routes in Slovakia’s cultural landscape, focusing on regions with marginal interest, low tourism engagement, and predominant monocultural blocks. The methodology was systematically applied to the Zemplín Geopark in eastern Slovakia, drawing upon historical cartographic records from the Josephine mapping period (1764–1787) to the present day. The investigation identified and delineated 14 hiking trails, offering historical and tourism significance while promoting multifunctionality. Our research introduces sustainable development avenues for regions with marginal interest, providing ecological and tourist benefits that enhance the overall quality of life. The findings align with the Common Agricultural Policy’s objectives for 2021–2027, addressing challenges related to large-scale field fragmentation. Two identified obstacles include property-legal challenges and issues arising from inadequate map registration, which current methods, unfortunately, fail to address.

On Seeing Long Shadows: Is Academic Medicine at its Core a Practice of Racial Oppression?

Suggestions that academic medicine is systemically racist are increasingly common in the medical literature. Such suggestions often rely upon expansive notions of systemic racism that are deeply controversial. The author argues for an empirical concept of systemic racism and offers a counter argument to a recent suggestion that academic medicine is systemically racist in its treatment of medical trainees: Anderson et al.'s(Academic Medicine, 98(8S), S28-S36, 2023) "The Long Shadow: a Historical Perspective on Racism in Medical Education." Contra the authors of "The Long Shadow," the author argues that racial performance disparities in medical education cannot be validly attributed to racism without careful empirical confirmation; he further argues that standards of assessment in medical education cannot be properly deemed racist merely because minority trainees are disproportionately disadvantaged by them. Furthermore, the history of medicine and society in the Anglo-European West is not, as argued by the authors of "The Long Shadow," best viewed as one long tale of racial oppression culminating in the present day pervasive racism of academic medicine in the United States. Racism is a deplorable stain on our history and our present but it is not the historical essence of Christianity, European civilization, Western medicine, or contemporary academic medical institutions.

Kerklike tug: Verleentheid of nuwe geleentheid?

Church discipline: embarrassment or a new opportunity? In 2004, 2007 and 2011 the General Synod of the Dutch Reformed Church decided that the way in which church discipline functions in the church, should be researched and investigated. This article is based on the doctoral study of the co-author, who tragically died of COVID-19 during the pandemic of 2020-2021. She investigated the development of church discipline in the Dutch Reformed Church from 1652 to the present day, to determine why church discipline has become an embarrassment to the church. This article is based on a part of the outcome of her research. The article discusses the purpose, nature of and need for church discipline, and states that the way in which members of the church understand discipline in the church, should change. The authors emphasise that church discipline must be built on the foundation of brotherly love within the framework of tolerant care. This will not only help to change the understanding of informal and formal church discipline but will also challenge the church to create a safe space for confession, forgiveness, and reconciliation. By doing so, church discipline as tolerant care will become part of the spiritual journey of members of the church. As such, it will change from being an embarrassment to becoming a huge opportunity for spiritual growth.Intradisciplinary and/or interdisciplinary implications: The article focuses on church discipline as tolerant care. In doing so, church discipline does not only function as part of the study field of Church Polity, but it also incorporates Practical Theology. The most important implication is that discipline is understood as care.

AI - Current Landscape and Future Predictions

This paper is the introduction to the Artificial Intelligence (AI) landscape in the present day and its future properties. AI is now being used in numerous fields, such as technology, finance and banking, and healthcare to name a few. The current use of AI is in automation, to perform tasks at the same level or even better than humans can in terms of efficiency, accuracy and speed. This is why AI is being used in more businesses, and why understanding AI has become more important than ever before. The majority of people don't truly understand what AI even is, and assume that it’s a dangerous field filled with killer robots, however that couldn’t be farther than the truth. The following chapters in this paper will explain what AI actually is as well as comparing it to the public’s perception. Once a proper understanding of AI is established, the paper aims to show how AI is being applied into industries, and how they can skyrocket the success of all of them in vast ways that were never possible before the AI revolution.

Do Societies Have Emotions?

In recent decades, there has been a growing interest in the study of emotions, demonstrating their importance in understanding diverse human and social dynamics. However, as this field of study develops and diversifies, a structural yet simple question remains virtually undiscussed: Is it really possible to say that societies possess emotions or a certain sensitivity akin to individual experiences? This exploratory study, based on documentary analysis, endeavours to identify and examine emotional patterns across six different periods, spanning from the Middle Ages to the present day. Among the eight secondary findings, three fundamental conclusions stand out: (1) throughout history, societies have experienced different emotional atmospheres, sometimes simultaneously; (2) although societies generally propose an emotional model to follow, the reality does not always conform to it; and (3) it is mainly through the culture that society creates a certain emotional harmony, allowing the social body to remain cohesive and develop, thus postponing or preventing its disintegration. This study aims to offer a modest contribution to the complex and under-explored discussion on the correlation between specific emotional climates and particular social contexts.