Abstract This analysis assesses the financial viability of legally investing in native Cerrado vegetation deforestation for crop production, considering climate change. The study uses data from twelve different crop models based on three different climate models to predict potential future crop yields in cleared land for growing soy and maize. The outcomes show that in many micro-regions, investments in clearing land for crop production would destroy economic value, that is, generate a negative net present value because of low/negative and volatile cashflows driven primarily by future yields as affected by climate. Our analysis was carried out based on present agricultural practices and technology. As climate changes, farmers may adapt their practices, which can lead to more resilient and productive crops, or grow different crops, which could provide better returns on investment in clearing land than the ones resulting from our analysis. Despite various uncertainties, farmers, policy makers and financial institutions should be aware of the climatic and financial risks associated with land clearing in Brazil, mainly in micro-regions in which all scenarios resulted in negative outcomes in the investment analysis.