Event Abstract Back to Event Clinical relevance of corrosion patterns attributed to inflammatory cell induced corrosion: A retrieval study Anna Di Laura1*, Harry Hothi1*, Jay Meswania1*, Robert Whittaker1*, Danielle De Villiers1*, Gordon Blunn1, John Skinner1* and Alister Hart1* 1 University College London, Institute of Orthopaedics and Musculoskeletal Science (IOMS), United Kingdom Introduction: Cobalt Chromium (CoCr) alloys are the most commonly used materials in orthopaedics. In vitro studies have shown that human osteoclasts can corrode Stainless Steel and Titanium forming resorption pits that lead to the production of metal ions responsible for inflammatory reactions [1],[2]. Moreover, traces of cellular activities on metal orthopaedic explants have recently been reported as Inflammatory Cell-Induced (ICI) corrosion being the result of the cells sealing on the metal surfaces and releasing Reactive Oxygen Species through Fenton-like reactions [3]. We aimed to better understand the clinical relevance of this phenomenon. Our objectives were 1) to determine the extent of ICI corrosion patterns observed in a large cohort of retrieved hip implants,2) to give a 3Dimensional characterisation to the corroded regions, 3) to correlate our findings with clinical data. Materials: This was a retrieval study involving 100 failed hip implants received at our centre with metal-on-metal (MOM) bearings. We selected Durom modular heads [n=25], Durom resurfacing [n=25] as well as ASR modular heads [n=25] and ASR resurfacing [n=25] for inspection, so that we included both metallurgical features for Co-Cr alloys: wrought and cast. Methods: Initial screening included macroscopic and microscopic analysis of both cups and heads with the aid of a stereomicroscope (Leica) and a digital microscope (Keyence). A scanning electron microscope (Jeol) was used to perform detailed analysis of specific areas of interest highlighted from the initial visual screening. Second and Backscattered Electron Imaging ranging from low (4-5) to high (10-15) kV were used. Energy dispersive X-ray spectrometry (EDS) assessed the elemental composition and organic biocorrosion products on the implant surface. A 3D optical microscope (Bruker) showed both depth of pits and deposition of material in µm.The significance of any univariable associations between the presence of ICI corrosion and key implant and clinical variables were assessed using simple linear regression models. Results: 59 % of implants had evidence of corrosion patterns as described by Gilbert et al. Haziness, pits and streaks were visible on the: polished regions of the heads as well as on internal edges of cups; and machining marks of acetabular rims and head rims (Figure1). Higher magnification images showed crater-like spots surrounded by a frosted pattern of a ruffled topography. SEM images confirmed the presence of the features probably derived from different cellular mechanisms . Further confirmation of this was achieved by the optical profilometer. Scaled maps gave information about depth of pits that ranged from 0.5 to 3µm. There was a significant association between ICI corrosion and aseptic loosening for the ASR modular (r=-0.488, p=0.016) and the Durom modular (r=0.454, p=0.026) explants. EDS analysis revealed the presence of iron in correspondence of corroded regions, the element was only detectable in proximity of the corrosion patterns. Discussion: Corrosion patterns potentially attributable to cell induced corrosion were found on 59% of retrieved hips. There was no difference between cast and wrought microstructures but there was a correlation between implants revised due to aseptic loosening and presence of cellular corrosion. Iron is also in accordance with the presence of phagocytic cells on the metal surfaces due to Fenton-like reaction taking place. We recommend further work to determine the role and type of cells in the corrosion damage patterns observed. This may help understand which patient factors are involved in hip implant failure: and whether some patients more prone to failure of CoCr implants?