Presence Of Novelty Research Articles

The familiarity hypothesis: Explaining the behavior of deep open set methods

In many object recognition applications, the set of possible categories is an open set, and the deployed recognition system will encounter novel objects belonging to categories unseen during training. Detecting such “novel category” objects is usually formulated as an anomaly detection problem. Anomaly detection algorithms for feature-vector data identify anomalies as outliers, but outlier detection has not worked well in deep learning. Instead, methods based on the computed logits of visual object classifiers give state-of-the-art performance. This paper proposes the Familiarity Hypothesis that these methods succeed because they are detecting the absence of familiar learned features rather than the presence of novelty. This distinction is important, because familiarity-based detection will fail in many situations where novelty is present. For example when an image contains both a novel object and a familiar one, the familiarity score will be high, so the novel object will not be noticed. The paper reviews evidence from the literature and presents additional evidence from our own experiments that provide strong support for this hypothesis. The paper concludes with a discussion of whether familiarity-based detection is an inevitable consequence of representation learning.

Norepinephrine as a spatial memory reset signal.

Contextual information is represented in the hippocampus (HPC) partially through the recruitment of distinct neuronal ensembles. It is believed that reactivation of these ensembles underlies memory retrieval processes. Recently, we showed that norepinephrine input from phasic locus coeruleus activation induces hippocampal plasticity resulting in the recruitment of new neurons and disengagement from previously established representations. We hypothesize that norepinephrine may provide a neuromodulatory mnemonic switch signaling the HPC to move from a state of retrieval to encoding in the presence of novelty, and therefore, plays a role in memory updating. Here, we tested whether bilateral dorsal dentate gyrus (dDG) infusions of the β-adrenergic receptor (BAR) agonist isoproterenol (ISO), administered prior to encoding or retrieval, would impair spatial working and reference memory by reverting, the system to encoding (thereby recruiting new neurons) potentially interfering with the retrieval of the previously established spatial ensemble. We also investigated whether dDG infusions of ISO could promote cognitive flexibility by switching the system to encoding when it is adaptive (ie, when new information is presented, eg, reversal learning). We found that intra-dDG infusions of ISO given prior to retrieval caused deficits in working and reference memory which was blocked by pretreatment with the BAR-antagonist, propranolol (PRO). In contrast, ISO administered prior to reversal learning led to improved performance. These data support our hypothesis that norepinephrine serves as a novelty signal to update HPC contextual representations via BAR activation-facilitated recruitment of new neurons. This can be both maladaptive and adaptive depending on the situation.

Robust hierarchical clustering for novelty identification in sensor networks: With applications to industrial systems

The paper proposes a new, robust cluster-based classification technique for Novelty Identification in sensor networks that possess a high degree of correlation among data streams. During normal operation, a uniform cluster across objects (sensors) is generated that indicates the absence of novelties. Conversely, in presence of novelty, the associated sensor is clustered distinctly from the remaining sensors, thereby isolating the data stream which exhibits the novelty. It is shown how small perturbations (stemming from noise, for instance) can affect the performance of traditional clustering methods, and that the proposed variant exhibits a robustness to such influences. Moreover, the proposed method is compared with a recently reported technique, and shown that it performs 365% faster computationally. To provide an application case study, the technique is used to identify emerging fault modes in a sensor network on a sub-15MW industrial gas turbine in presence of other abrupt, but normal changes that visually might otherwise be interpreted as malfunctions.

Involvement of classical neurotransmitter systems in memory reconsolidation: Focus on destabilization.

When consolidated long-term memories are reactivated they can destabilize, rendering the memory labile and vulnerable to modification. This period of lability is followed by reconsolidation, a process that restabilizes the memory trace. Reactivation-induced memory destabilization is the gateway process to reconsolidation, but research in this area has focused primarily on the mechanisms underlying post-reactivation restabilization. As a result, our understanding of processes subserving destabilization have lagged behind those responsible for reconsolidation. Here we review the literature investigating the neural basis of reactivation-induced memory destabilization. We begin by reviewing memory destabilization broadly and the boundary conditions that influence the likelihood of reactivated memories to destabilize. We then discuss the fact that boundary conditions can be overcome in the presence of novelty, providing evidence for the theory that reconsolidation is a mechanism for memory updating. From here, we delve into a detailed review of the role of classical neurotransmitter systems, including dopamine, serotonin, noradrenaline, glutamate, GABA and acetylcholine, in reconsolidation, with a focus on their involvement in destabilization. Many of these neurotransmitters appear capable of promoting memory destabilization, and research investigating the cellular pathways through which they influence destabilization is a growing area. However, gaps remain in our understanding of how these neurotransmitters work in conjunction with one another to support destabilization across different types of memory and in different brain regions. Advances in the coming years within this research field should greatly contribute to our understanding of the neural mechanisms that influence the dynamic process of long-term memory storage and modification, information crucial to the development of potential treatments for disorders characterized by strong, maladaptive memories.

Reward-related limbic memory and stimulation of the cannabinoid system: An upgrade in value attribution?

While a lot is known about the mechanisms promoting aversive learning, the impact of rewarding factors on memory has received comparatively less attention. This research investigates reward-related explicit memory in male rats, by taking advantage of the emotional-object recognition test. This is based on the prior association, during conditioned learning, between a rewarding experience (the encounter with a receptive female rat) and an object; afterwards rat discrimination and recognition of the 'emotional object' is recorded in the presence of a novel object, as a measure of positive limbic memory formation. Since endocannabinoids are critical for processing reward and motivation, the consequences of the stimulation of cannabinoid signalling are also assessed by the administration of WIN 55,212-2 at pre- and post-conditioning time. Our results show that rats encode the association between object and rewarding experience, form positive limbic memory of the emotional object, and retrieve this information in the face of novelty. Stimulation of the cannabinoid system at pre-conditioning time is able to strengthen reward-related explicit memory in the presence of novelty, whereas post-conditioning activation increases approach behaviour to novel stimuli. The assessment of limbic memory by the emotional-object recognition test can help unveiling the addictive and confounding properties of psychotropic drugs.

Habituation to test procedure modulates the involvement of dopamine D2- but not D1-receptors in ethanol-induced locomotor stimulation in mice

Novelty associated with behavioral testing has been shown to enhance psychostimulant- and morphine-induced locomotor stimulation. Evidence has demonstrated that novelty increases dopamine (DA) activity, and habituation to a novel environment reduces such activation. However, it is not clear whether novelty modulates ethanol-induced behavioral stimulation and whether DA plays a role in this effect. The present work sought to demonstrate a role of habituation to test procedure as a factor that could modulate the involvement of DA in ethanol-induced locomotor stimulation. Non-habituated (NH) and habituated (H) Swiss mice pretreated with DA D1- (SCH23390; 0-0.045 mg/kg) or D2-receptor (sulpiride; 0-50 mg/kg) antagonists were tested for ethanol (0-2.5 g/kg)-induced locomotor stimulation. Experiments with amphetamine (0-4 mg/kg), morphine (0-5 mg/kg) and caffeine (0-15 mg/kg)were designed to compare their results to those obtained with ethanol. The effect of the non-selective opioid receptor antagonist naltrexone (0-1.5 mg/kg) was also tested on ethanol-induced locomotor stimulation. NH and H animals did not differ in their locomotor response to ethanol or caffeine; however, amphetamine- and morphine-induced stimulation was greater in NH than in H mice. SCH23390 only reduced ethanol-induced stimulation at doses that also reduced spontaneous activity in both NH and H mice. Sulpiride decreased ethanol-stimulated behavior only in the NH condition. Habituation did not modify the effect of sulpiride on amphetamine-, morphine- or caffeine-induced activation. Naltrexone (0-1.5 mg/kg) reduced ethanol-induced stimulation regardless of habituation. The present data suggest that the participation of DA D2-receptors in ethanol-induced behavioral stimulation requires the presence of novelty. Results also support the involvement of neurotransmitter systems other than DA (i.e., endogenous opioid system) as important substrates mediating ethanol-induced locomotor activation.

Gender-specific effects of prenatal stress on emotional reactivity and stress physiology of goat kids

The aims of this study were to investigate the effects of maternal stress during pregnancy on the emotional reactivity, the hypothalamo–pituitary–adrenocortical (HPA) axis, and the sympatho-adrenomedullary (SAM) system of goat offspring according to their gender, and to investigate the role of maternal cortisol in prenatal stress effects. Goats were exposed to ten transports in isolation or ten ACTH injections (0.125 IU/kg body weight) during the last third of pregnancy. Control goats remained undisturbed. No effect of repeated transport during the last third of pregnancy was found on basal cortisol concentrations of the offspring. However, an increase in phenylethanolamine N-methyl transferase activity in the adrenals was observed in prenatally stressed kids compared to control kids ( P = 0.031). In the presence of novelty, prenatally stressed female kids were more active ( P = 0.049) than control females; they also showed more signs of arousal ( P = 0.039) and tended to explore more of their environment ( P = 0.053) in reaction to a startling stimulus. On the contrary, prenatally stressed male kids tended to be less active ( P = 0.051) than control male kids but showed more signs of distress ( P = 0.047) in the presence of novelty. Intermediate effects were found on the emotional reactivity to novelty of kids born from dams given injections of ACTH. In conclusion, transport stress in pregnant goats affects the sympatho-adrenomedullary system and the emotional reactivity of their offspring in a gender-specific manner. Moreover, the effects of prenatal transport and ACTH injections showed some similarities but differed in some critical details.

Neophobia and its effect on the macro‐structure and micro‐structure of feeding in wild brown rats (Rattus norvegicus)

The effect of neophobia (fear of novelty) on feeding behaviour was examined in two groups of captive wild rats fed ad libitum. Different individuals employed different feeding patterns in response to novelty despite the absence of social and ecological constraints. The prevalent feeding pattern was to delay eating from a novel bowl several nights after it was introduced and, in general, novel food was sampled towards the end of a night. Systematic relationships (prandial correlations) were revealed in the meal pattern data which were consistent with the prediction that post‐prandial correlations (controlled regular feeding bouts) are more likely in predictable environments. A large proportion of the individuals exhibited no prandial relationships which correlated with high levels of neophobia supporting the hypothesis that highly neophobic individuals are less able to regulate their feeding in the presence of novelty.

Resource Acquisition in the Presence of Novelty by Coyotes of Different Rank

We investigated acquisition of food by 3- to 6-month-old-band reared coyotes (Canis latrans) of different social rank in an area familiar to the coyotes with and without novel objects (safe and potentially unsafe environments). We tested the hypothesis that dominant coyotes were more hesitant than subordinates in approaching food in the presence of a novel stimulus. We found that dominant pups initiated feeding more often under familiar conditions than when exposed to a noval stimulus (75 vs. 6% of the trials). We also determined if the behavior of subordinates in the test was caused by the presence of a higher-ranking individual, or alternatively, was a response that occurred without the dominant's presence. When the pups were tested individually, there was no difference between dominants and subordinates in response to novel conditions. We suggest that social rank plays a role in a coyote's vulnerability to novel conditions and objects (e.g., traps), especially when in a group

Differential effects of anxiolytics and beta-receptor blocking drugs on novelty-oriented ("neophobic") behavior in the rat.

The effects of diazepam, I-propranolol and isamoltane (CGP 361 A) (I-isopropylamino-3[2-(I-pyrrolyl)-phenoxy]-2-propranol), a drug with beta-receptor blocking and anxiolytic-like properties, on behavioral responses in rats encountering either a novel object or a drinking bottle in an unfamiliar open-field ("neophobic" behavior) were evaluated. Diazepam (1-5 mg/kg p.o.) and isamoltane (0.5-1.0 mg/kg p.o.) showed a similar pattern of effects in both test paradigms used. They counteracted the fear-induced suppression of behavioral responses in the presence of novelty: they shortened the approach latencies, increased the exploration-oriented activities and reduced grooming. Propranolol, however, in comparison with isamoltane (1.0 and 2.5 mg/kg i.p.) at equivalent doses, failed to significantly change any of the parameters measured in either of the two test situations. The results therefore indicate that neophobic behavioral responses discriminate between central anxiolytic and peripheral beta-blocking actions of drugs and further validate neophobic behavior as an animal model of anxiety.