Presence Of Depression In Patients Research Articles

Correlation of Specific Inflammatory Markers With the Occurrence of Depression in Patients With Psoriasis and Their Use as Biomarkers for the Diagnosis of Depression.

Psoriasis is a systemic disease of the skin and nails associated with a wide range of comorbidities such as depression, psoriatic arthritis and metabolic syndrome. The study aimed to examine a potential association between inflammatory markers (C- reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and depression in patients with psoriasis. A total of 80 individuals were enrolled in the study. Case participants included 28 patients diagnosed with Psoriasis (Beck Depression Inventory-II: :0-13) and 24 patients diagnosed with Psoriasis and Depression (Beck Depression Inventory-II:14-63). Twenty-eight (28) healthy participants comprised the control group.Psoriasis severity was evaluated by using Psoriasis Area and Severity Index, Physician Global Assessment, Body Surface Area and Dermatology Life Quality Index. Written approval was obtained for its use in this study: Cardiff University (09/2015). Other factors considered in the study were obesity using the Body Mass Index, the levels of stress using the Beck Anxiety Inventory, and the presence of insomnia using the Athens Insomnia Scale. Blood draws and inflammatory markers measurements were performed for all participants. Both CRP and ESR levels were higher in the case group (ie Psoriasis and Depression and Psoriasis) compared to healthy controls. Furthermore, psoriatic patients with depression showed increased CRP and ESR levels compared to those of psoriatic patients without depression. The evaluation of both CRP and ESR and their use to detect the presence of depression in patients with psoriasis can be an important tool for their holistic treatment of theirs.

Gender differences in the association of dementia and depression

IntroductionThe evolution of depression and dementia has been shown to differ in some studies. For example, a history of recent depression has been found to be associated with an increased risk of Alzheimer’s disease in women (Kim et al., 2021).ObjectivesWe will use data collected from several dementia studies to analyze whether the presence of depression at diagnosis is more frequent in women.MethodsWe conducted a systematic search for articles analyzing the presence of depression in patients with a diagnosis of dementia. We analyzed by Student’s t test the presence of depression according to sex, considering the alternative hypothesis that there is more depression in female than male patients.ResultsThe mean age of the sample was 71 years. We obtained a statistically significant Student’s t test (p=0.02).ConclusionsThe approach and approach to depression in the elderly as a risk factor could be different according to sex. For example, some studies have proposed the use of hormone replacement therapy (HRT) after menopause as a possible protective factor for the subsequent development of dementia (Kim et al., 2022). Further studies are recommended in this regard.Disclosure of InterestNone Declared

Association between depression and diabetes in the South-Eastern zone of the state of Uttar Pradesh-India: A cross-sectional study

Background: Depression is among the most common mental health problems among people with chronic complications like type 2 diabetes mellitus is brought on by flaws in insulin secretion and activity; however, genetic factors also play a role in both insulin resistance and beta-cell failure, but environmental factors also play a role in aggravating both problems. The presence of depression in patients with type 2 diabetes may interfere with treatment and efficacy. This study aimed to determine the prevalence of depression in this metabolic variant clinical condition, type 2 diabetes mellitus, in major tertiary care hospitals in the South-Eastern Uttar Pradesh cities of Allahabad and Varanasi. Subjects and methods: For this study, 206 subjects with type 2 diabetes mellitus from rural and urban areas were recruited. Demographic, clinical, and diabetes-related data were collected using a semi-structured questionnaire. Depression was assessed using the Patient Health Questionnaire 9 (PHQ9), a standardized questionnaire developed in the United States and validated in the Indian population. Results: The prevalence of depression in diabetics in the community was 43.2%. The most common type of depression was mild (29.3%, 26), and the least common was severe depression (3, 3.37%). Several factors were associated with depression in the female gender: living in a rural area, unemployment, and being single. The complications of diabetes and other chronic conditions, such as hypertension and obesity, are also associated with depression. Conclusion: Depression was found to be particularly high in the study population. Because depression can significantly impede patient adherence to treatment, there is an urgent need for early diagnosis and treatment. This requires integrating mental health care for diabetes patients. Keywords: prevalence; diabetes; depression; community; higher rate

Differentially expressed genes associated with presence of depression in patients with obesity undergoing bariatric surgery

Differentially expressed genes associated with presence of depression in patients with obesity undergoing bariatric surgery

Depression in patients with inflammatory bowel disease is associated with increased risk of dementia and Parkinson's disease: A nationwide, population-based study.

BackgroundInflammatory bowel disease (IBD) may be associated with depression which is considered an important cause of dementia and Parkinson’s disease (PD). In the present study, the effects of depression on the development of dementia and/or PD in patients with IBD were evaluated.Materials and methodsA nationwide population-based cohort study was conducted using claims data from the Health Insurance Review and Assessment Service in Korea. The incidence of dementia and PD were analyzed based on the presence of depression in patients with IBD.ResultsDuring a mean follow-up of 8 years, IBD patients with depression experienced dementia (6.7 vs. 2.0%; p < 0.001) and PD (1.1 vs. 0.3%; p < 0.001) significantly more than IBD patients without depression. Compared with IBD patients without depression, the risk of developing dementia was significantly higher in IBD patients with depression [adjusted hazard ratio (aHR) for IBD, Crohn’s disease (CD), and ulcerative colitis (UC), 2.03, p < 0.001; 1.68, p = 0.033; 2.13, p < 0.001, respectively]. Compared with IBD patients without depression, the risk of developing PD was significantly higher in IBD patients with depression (aHR for IBD, CD, and UC, 2.54, p < 0.001; 1.93, p = 0.470; 2.75, p < 0.001, respectively). The cumulative incidence of dementia and PD in IBD patients with depression was significantly higher than in IBD patients without depression and showed a steady increase after a diagnosis of depression.ConclusionThe risk of dementia and/or PD increased after a diagnosis of depression in patients with IBD.

Prevalence of Depression among the Patients with Type 2 Diabetes Mellitus Attending the Urban Health Training Centre, Thirumazhisai, Tamilnadu

Introduction: Depression is the more common mental health condition found among the chronic diseases. The prevalence of both diabetes and depression are rapidly increasing and the presence of depression in patients with type 2 diabetes could hinder the adherence and effectiveness of treatment. Objective: This study aimed to estimate the prevalence of depression and to identify the factors influencing depression among patients with type 2 diabetes mellitus in NCD clinic Method: A cross – sectional study was conducted among Type 2 diabetes mellitus attending the NCD clinic of the urban health training centre between January and April 2021. Demographic, clinical and diabetes related information was collected through a semi – structured questionnaire. Level of depression was assessed using a standard questionnaire (PHQ – 9 questionnaire). The total score of 5 – 9, 10 – 14 and &gt;15 were graded as mild, moderate and severe forms of depression respectively. Data analysis was done using SPSS software version 21. Results: The mean age of the study subjects was 53+7 yrs and majority (60%) were males. The prevalence of depression was 30.8 % and among them 71.7 % had mild depression while 12.8 % had severe form of depression. Factors such as female gender, higher educational status and substance use such as alcohol and smoking were found to be significantly associated with the presence of depression. Conclusion: It is imperative to screen for depression and lay emphasis on counseling services for the effective management of diabetes thereby improve the quality of their life.

Cognitive and/or Depressive Disorders in the Elderly with Type II Diabetes Mellitus Associated with Hypertension

Abstract Type 2 diabetes mellitus is a significant public health problem due to its increasing prevalence, being considered a major risk factor for cardiovascular diseases, thus being an important cause of morbidity and mortality globally. NICE (The UK’s National Institute for Excellence in Health and Care) states that people diagnosed with diabetes (both type 1 and type DZ 2) have a three times higher risk of being diagnosed with depression compared to those who do not have diabetes. Studies on the association of diabetes mellitus in the elderly and neurocognitive disorders have highlighted the increased incidence of dementia in this type of patient, the latter representing a risk factor for the development of strokes. The purpose of the study: to study the presence of neurocognitive dysfunction and the presence of depression in patients who simultaneously present type 2 diabetes mellitus and hypertension, and the correlations between clinical-psychiatric indicators (MMSE score and GDS-15 score) and paraclinical indicators (blood glucose level, HbA1c, total cholesterol, triglycerides, HDL- and LDL-cholesterol), as well as blood pressure values at admission, during hospitalization and at discharge. 120 patients with type 2 diabetes mellitus and HTA were examined, who followed the treatment at the National Institute of Geriartry and Gerontology “Ana Aslan” in Bucharest, registered between April 2021 and April 2022. Conclusions: According to the data exposed, it can be stated that there is a high probability of the development of cerebral suffering, which can generate cognitive decline of various stages of severity, in decompensated diabetic patients.

Associated factors of depressive symptoms in patients with erectile dysfunction

The presence of depression in patients with erectile dysfunction not only worsened the condition but also makes its management more complicated. We conducted a cross-sectional study to investigate several factors associated with depression of 131 patients with erectile dysfunction at Hanoi Medical University Hospital. The depression rate of the subjects was 45.8%. Compared with the non-depressive group, the patients with depression had a lower mean age (39 ± 13.3 and 50 ± 14.1 years old, p &lt; 0.001) and a greater frequency of masturbation (0.6 ± 1 and 0.1 ± 0.5 times/week, p = 0.001). The factors that correlate with the severity of depression on the PHQ-9 scale were age and masturbation frequency (r = -0.352 and 0.346, p &lt; 0.001). The factors associated with depression include age under 40 (OR = 5.15, p &lt; 0.001), single (OR = 6.53, p &lt; 0.001), masturbation (OR = 5.02, p = 0.001) and the sudden onset of erectile dysfunction (OR = 2.36, p = 0.03). The results show that depression occurs in patients with erectile dysfunction at a relatively high rate, therefore, depression needs to be screened for this group of patients, especially those with risk factors.

Investigation of depressive symptoms among male patients with erectile dysfunction

Erectile dysfunction (ED) is one of the causes of depression. The presence of depression in patients with erectile dysfunction worsened the condition. We conducted a study among 60 men diagnosed with erectile dysfunction who had depression using the PHQ-9 scale to determine the prevalence and characteristics of depression. The mean age of the subjects was 39 ± 13.3 years old, where 31.7% were single. The participants’ average BMI was 23.1 ± 2.4 kg/m2 and average testosterone level was 17.5 ± 6.5 nmol/L. The rates of mild, moderate, and moderately severe depression of the study subjects were 68.3%, 25% and 6.7%, respectively. The most common and severe symptoms of depression were loss of interest, loss of energy, and depressed mood. We suggest that depression should be noticed and screened in patients with erectile dysfunction.

The Phenotypes of Anxiety and Depression: Analysis of Combined Comorbidity and Treatment in Patients Undergoing Spinal Fusion.

Anxiety and depression are associated with suboptimal outcomes, higher complications, and cost of care after elective spine surgery. The effect of combined anxiety-depression and preoperative antidepressant treatment in spinal fusion patients is not known. To study the burden of combined anxiety-depression and its impact on healthcare utilization and costs in patients undergoing spinal fusion and to study the prevalence and impact of antidepressant treatment preoperatively. This is a retrospective cohort study from the IBM MarketScan Research Database (2000-2018). Patients were studied in 7 different "phenotypes" of anxiety and depression based on combination of diagnoses and treatment. Outcome measures included healthcare utilization and costs from 1 year preoperatively to 2 years postoperatively. Bivariate and multivariable analyses have been reported. We studied 75 087 patients with a median age of 57 years. Patients with combined anxiety-depression were associated with higher preoperative and postoperative healthcare utilization and costs, as compared with anxiety or depression alone. The presence of depression in patients with and without anxiety disorder was a risk factor for postoperative opioid use and 2-year reoperation rates, as compared with anxiety alone. Patients with anxiety and/or depression on antidepressants are associated with significantly higher healthcare costs and opioid use. The adjusted 2-year reoperation rate was not significantly different between treated and untreated cohorts. Spine surgeons should use appropriate measures/questionnaires to screen depressed patients for anxiety and vice versa because the presence of both adds significant risk of higher healthcare utilization and costs over patients with 1 diagnosis, especially anxiety alone.

Altered Dynamic Functional Connectivity in de novo Parkinson's Disease Patients With Depression.

BackgroundDepression is one of the most prevalent and disturbing non-motor symptoms in Parkinson’s disease (PD), with few dynamic functional connectivity (dFC) features measured in previous studies. Our aim was to investigate the alterations of the dynamics in de novo patients with PD with depression (dPD).MethodsWe performed dFC analysis on the data of resting-state functional MRI from 21 de novo dPD, 34 de novo patients with PD without depression (ndPD), and 43 healthy controls (HCs). Group independent component analysis, a sliding window approach, followed by k-means clustering were conducted to assess functional connectivity states (which represented highly structured connectivity patterns reoccurring over time) and temporal properties for comparison between groups. We further performed dynamic graph-theoretical analysis to examine the variability of topological metrics.ResultsFour distinct functional connectivity states were clustered via dFC analysis. Compared to patients with ndPD and HCs, patients with dPD showed increased fractional time and mean dwell time in state 2, characterized by default mode network (DMN)-dominated and cognitive executive network (CEN)-disconnected patterns. Besides, compared to HCs, patients with dPD and patients with ndPD both showed weaker dynamic connectivity within the sensorimotor network (SMN) in state 4, a regionally densely connected state. We additionally observed that patients with dPD presented less variability in the local efficiency of the network.ConclusionsOur study demonstrated that altered network connection over time, mainly involving the DMN and CEN, with abnormal dynamic graph properties, may contribute to the presence of depression in patients with PD.

Učestalost depresije kod pacijenata sa subkliničkom i kliničkom hipotireozom - studija preseka

Introduction. Hypothyroidism can be accompanied by various neuropsychiatric manifestations ranging from mild depression and anxiety to psychosis. Objective. The study aimed to determine the presence of depression in patients with hypothyroidism (clinical and subclinical). Methods. The survey was conducted over twenty-four months, from 01. 07. 2017. to 01. 07. 2019., at the Health Center Krupa na Uni. The cross-sectional study included 160 persons, two groups of 80 persons each. The first group included those with newly diagnosed hypothyroidism, while the control group consisted of people with neat, thyroid function. In addition to the general questionnaire, the study used Beck's Depression Inventory and laboratory analyzes (enzymatic assays to determine thyroid stimulating hormone and thyroxine). The chi-square test was used in the statistical analysis. Results. The first group consisted of 62 (38.7%) subjects with subclinical hypothyroidism and 18 (11.3%) with clinical hypothyroidism, 51 (63.7%) women and 29 (36.3%) men with a mean age of 52±6.9 years. The control group consisted of 42 (52.5%) women and 38 (47.5%) men, with a mean age of 51±4.3 years. Mild depression was verified in 50 (31.2%), moderately severe in 43 (26.9%), and severe depression in 3 (1.9%). The study found the existence of statistically significantly moderate-severe depression in participants with subclinical hypothyroidism (p&lt;0.05). Conclusion. The results of our study indicate a statistically significantly presence of moderately severe depression in patients with subclinical hypothyroidism. Early detection and adequate therapeutic intervention of thyroid gland disorders in patients with depression. Our findings favor the need for early and routine screening for hypothyroidism and depression.

Prevalence and correlates of depression among patients with chronic kidney disease

Background This study sought to determine the prevalence and correlates of depression among patients with chronic kidney disease (CKD). Patients and methods This is a comparative cross-sectional study of 69 patients with CKD, who were selected by systematic random sampling and matched (by age and sex) with a control group of 69 hospital workers. Eligible and consenting participants completed a sociodemographic questionnaire and were interviewed with the Mini International Neuropsychiatry Interview. Data were analyzed with the Statistical Package for Social Sciences, version 21. P value less than 0.05 was considered significant. Results The mean age of the patients was 44.7 years (SD ±10.14 years). The patients included 53% females. The prevalence of depression among patients with CKD was 34.8% compared with 2.9% in the control group (P=0.0001). A significant relationship was found between the average monthly income and presence of depression in patients with CKD (P=0.015). There was no association found between the prevalence of depression and the stage of CKD. Conclusion Depression is very common in patients with CKD. Assessment for depression should be integrated into the care plan for patients with CKD, so as to ensure early detection and prompt intervention.

Comorbidity of unipolar depression in patients of vitiligo attending tertiary care hospital

Background: Vitiligo is one of the most common dermatological illnesses with localized depigmentation leading to cosmetic impairment. This also causes impairment of physical, psychological, social functioning of individual which in turn leads to psychiatric morbidities such as anxiety and depression. Aims and Objective: The present hospital based study was carried out to evaluate the presence of depression in patients of vitiligo patients in their different socio demographic variables. In addition, attempts were made to measure the severity of depression in those patients. Material and Methods: This was a hospital based cross-sectional study. Eighty patients of vitiligo with lesions in the exposed body parts were enrolled for the study after their informed consent with purposive sampling method from the Department of Dermatology, in a tertiary care hospital in north eastern part of India and compared them with those of healthy control. Those patients were evaluated by using ICD-10 research criteria and 17 item Hamilton rating scale of depression to diagnose and grade the degree of depression. Data were collected and “Chi Square Test” or “Fisher Exact t Test” was used. Mean value and standard deviation were calculated. All analysis were done using SPSS version 20.0. Results: Co morbidity of depression was significantly higher in vitiligo group (23.75%) in comparison to control group (6.25%). Among the depressed patients 68.43% had mild depression and 31.57% had moderate depression. Depression was inversely proportional to the years of education. Conclusions: These findings indicate the need of early recognition of depression among these patients and their early intervention, which will improve the primary disease process positively.

Illness perception in patients with lymphoproliferative diseases

Survival of patients with lymphoproliferative diseases increases. For effective treatment we should pay attention to a subjective understanding of the patients’ perception of the disease, which depends on the personality characteristics, emotional experiences and expectations of treatment. We used The Brief Illness Perception Questionnaire (BIPQ) for assess the illness perception in patients with chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). We included 94 patients with a diagnosis of lymphoproliferative disease (chronic lymphocytic leukemia - 42 people, multiple myeloma - 52) into this study: 55 (58.51%) men and 39 (41/49%) women. The average age of patients was 63,37 ± 9,96 years. The mean scores of the points of the BIPQ were as follows: Consequences – 7,28 ± 2, 88 ; Timeline – 7,52 ± 2,99; Personal control – 6,79 ± 3,12; Treatment control – 7,64 ± 2,40; Identity – 7,54 ± 2,87; Concern – 7,45 ± 2, 82 ; Understanding – 7,29 ± 2,81; Emotional response – 6,1 ± 3, 26. The results of all components of the questionnaire in patients with lymphoproliferative diseases were higher compared with breast cancer, diabetes, asthma patients. Illness perception according to the BIPQ was similar to those of patients with non-psychotic depressions. Overall threat level of the disease was high (57, 5 ± 11, 99). The most frequent causes of the disease according to the patients perception were: stress, work with harmful production, ecology, genetics. Patients with lymphoproliferative diseases showed high scores on BIPQ, this is probably due to the presence of depression in patients and requires further study.

Headache and Its Management in Patients With Multiple Sclerosis.

The purpose of this review was to discuss the prevalence, impact, pathophysiology, and treatment of headaches (H/As) in patients with multiple sclerosis (MS). Headaches and multiple sclerosis are more common in women than in men with the ratio of female to male being 3:1. It is not entirely clear if there is a correlation or an incidental comorbidity of two neurological conditions. A review of the literature shows a variable prevalence of H/As in MS patients. Using the International Classification of Headache Disorders (ICHD) criteria, the primary type of H/As, especially migraine, is the most common type seen in patients with MS. One of the theories of the pathophysiologic mechanisms of migraine in MS patients is inflammation leading to demyelinating lesions in the pain-producing centers in the midbrain. Secondary H/As due to MS medications such as interferons are also frequently present. H/As can be a cause for significant comorbidity in patients with MS. The treatment of H/As in patients with MS should be addressed in the same fashion as in the non-MS population, which is a combination of pharmacological and non-pharmacological methods. Preventive medicines for the H/As should be carefully selected because of their side effect profiles. Acute attacks of migraines can be treated with medications such as triptans. Patients with MS who have migraine H/As should be educated about the phenomenon of overuse H/As, keeping headache journals, avoiding stress, and monitoring sleeping habits. The presence of depression in patients with MS and migraine affects quality of life (QOL) and should also be addressed for better outcomes.

Time Trends in Characteristics of Patients Undergoing Primary Total Hip and Knee Arthroplasty in California, 2007-2010

BackgroundAs the number of total hip and knee arthroplasty cases increases, it is important to understand the burden of factors that impact patient outcomes of these procedures. This article examined the time trends in key demographics, clinical characteristics, comorbidity burden (Deyo-Charlson Comorbidity Index [CCI]), and presence of depression in patients undergoing primary total hip arthroplasty and total knee arthroplasty using population-based, all-payer inpatient database, California Healthcare Cost and Utilization Project, from 2007 to 2010. MethodsChi-square tests and analysis of variance were used. Multivariate logistic regression analyses were also performed to compare the prevalence of depression in 2007 to later years. ResultsIn the primary total hip arthroplasty cohort, the prevalence of depression significantly increased by 20%, mean age decreased by 0.4 years, mean length of stay (LOS) decreased by 0.5 days, and having a CCI score of ≥3 increased by 30% (P value < .001 for all) over the study period. Similarly, in the primary total knee arthroplasty cohort, the prevalence of depression increased by 23%, the mean age decreased by 0.4 years, mean LOS decreased by 0.4 days, and the prevalence of CCI score of ≥3 increased by 35% (P value < .001 for all). ConclusionDespite the younger age of the joint arthroplasty population over time, we found increased prevalence of depression and comorbidity scores but shorter LOS. Further study is needed to determine the impact of the changing demographics of the total joint population and the best strategies to optimize their outcome with these procedures.

Depression and Epilepsy: Comorbidity, Pathogenetic Similarity, and Principles of Treatment

The literature has in recent years seen confi rmation of the link between depression and epilepsy, with mutual increases in the severity of both diseases. The presence of depression in patients with epilepsy has been shown to increase the risk of developing fi rst unprovoked episodes, to decrease compliance, to lead to decreases in responses to both pharmacological and surgical treatment, to increase the risk of developing side effects of antiepileptic drugs, and to lead to decreases in overall quality of life. In addition, the presence of depression is linked with a high risk of suicidal behavior. Most cases of depression in epilepsy are characterized by an atypical course, which hinders diagnosis and treatment. The situation is exacerbated by patients’ fear of increases in stigmatization associated with mental illness. In this case, depression becomes the cause of the lack of timely pharmacological and psychotherapeutic intervention. Nonetheless, patients with comorbid depression visit doctors 2–4 times more frequently than those without depression, leading to signifi cant increases in the economic burden for the healthcare system.

Pre-ESRD Depression and Post-ESRD Mortality in Patients with Advanced CKD Transitioning to Dialysis.

Depression in patients with nondialysis-dependent CKD is often undiagnosed, empirically overlooked, and associated with higher risk of death, progression to ESRD, and hospitalization. However, there is a paucity of evidence on the association between the presence of depression in patients with advanced nondialysis-dependent CKD and post-ESRD mortality, particularly among those in the transition period from late-stage nondialysis-dependent CKD to maintenance dialysis. From a nation-wide cohort of 45,076 United States veterans who transitioned to ESRD over 4 contemporary years (November of 2007 to September of 2011), we identified 10,454 (23%) patients with a depression diagnosis during the predialysis period. We examined the association of pre-ESRD depression with all-cause mortality after transition to dialysis using Cox proportional hazards models adjusted for sociodemographics, comorbidities, and medications. Patients were 72±11 years old (mean±SD) and included 95% men, 66% patients with diabetes, and 23% blacks. The crude mortality rate was similar in patients with depression (289/1000 patient-years; 95% confidence interval, 282 to 297) versus patients without depression (286/1000 patient-years; 95% confidence interval, 282 to 290). Compared with patients without depression, patients with depression had a 6% higher all-cause mortality risk in the adjusted model (hazard ratio, 1.06; 95% confidence interval, 1.03 to 1.09). Similar results were found across all selected subgroups as well as in sensitivity analyses using alternate definitions of depression. Pre-ESRD depression has a weak association with post-ESRD mortality in veterans transitioning to dialysis.

Increased Risk of Incident Chronic Kidney Disease, Cardiovascular Disease, and Mortality in Patients With Diabetes With Comorbid Depression.

It is not known if patients with diabetes with depression have an increased risk of chronic kidney disease (CKD). We examined the association between depression and incident CKD, mortality, and incident cardiovascular events in U.S. veterans with diabetes. Among a nationally representative prospective cohort of >3 million U.S. veterans with baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2, we identified 933,211 patients with diabetes. Diabetes was ascertained by an ICD-9-CM code for diabetes, an HbA1c >6.4%, or receiving antidiabetes medication during the inclusion period. Depression was defined by an ICD-9-CM code for depression or by antidepressant use during the inclusion period. Incident CKD was defined as two eGFR levels <60 mL/min/1.73 m2 separated by ≥90 days and a >25% decline in baseline eGFR. The associations between depression and outcomes were assessed using Cox proportional regression. Depression was present in 340,806 patients at enrollment. Depressed patients were younger (61 ± 11 vs. 65 ± 11 years), had higher eGFR (84 ± 15 vs. 81 ± 14 mL/min/1.73 m2), but had more comorbidities. Incident CKD developed in 180,343 patients. Depression was associated with 20% higher risk of incident CKD (adjusted hazard ratio [aHR] and 95% CI: 1.20 [1.19-1.21]). Similarly, depression was associated with increased all-cause mortality (aHR and 95% CI: 1.25 [1.24-1.26]). The presence of depression in patients with diabetes is associated with higher risk of developing CKD compared with nondepressed patients. Intervention studies should determine if effective treatment of depression in patients with diabetes would prevent major renal and cardiovascular complications.