1. Henry M. Adam, MD 1. Editor, In Brief, Bronx, NY 1. 1. Sullivan JE, 2. Farrar HC Clinical Report—Fever & Antipyretic Use in Children. Sullivan JE, Farrar HC Section on Clinical Pharmacology & Therapeutics and Committee on Drugs. Pediatrics. 2011;127:580–587 [OpenUrl][1][Abstract/FREE Full Text][2] 2. 1. Schmitt BD Fever Phobia: Misconceptions of Parents about Fevers. Schmitt BD. Am J Dis Child. 1980;134:176–181 [OpenUrl][3][CrossRef][4][PubMed][5] 3. 1. May A, 2. Bauchner H Fever Phobia: The Pediatrician’s Contribution. May A, Bauchner H. Pediatrics. 1992;90:851–854 [OpenUrl][6][Abstract/FREE Full Text][7] 4. 1. Simon HB Hyperthermia. Simon HB. N Engl J Med. 1993;329:483–487 [OpenUrl][8][CrossRef][9][PubMed][10][Web of Science][11] 5. 1. Adam HM 1. McInerny TK, 2. Adam HM, 3. Campbell DE, 4. Kamat DM, 5. Kelleher KJ Physiology & Management of Fever. Adam HM. In: McInerny TK, Adam HM, Campbell DE, Kamat DM, Kelleher KJ, eds. American Academy of Pediatrics Textbook of Pediatric Care. Elk Grove Village, IL: American Academy of Pediatrics; 2009:418–422 At least in Western cultures we have a strong tradition of viewing fever not only as a response to illness but also as a disease itself. Although our science teaches us that fever, as part of the inflammatory response, is only a sign or symptom of the real pathologic process, our nomenclature (blackwater, cat scratch, dengue, hay, jungle, puerperal, rat bite, relapsing, rheumatic, Rocky Mountain spotted, scarlet, typhoid, and yellow fever) reinforces the temptation to treat fever as if it were the noxious culprit itself. Fever, as opposed to hyperthermia, rarely poses a threat to a child’s well-being; in fact, as an energy-expensive phenomenon, fever is not likely to have weathered evolution without conferring some survival benefit. Considering that fever is the most common signal of illness in children, serving as the cause of as many as a third of all pediatric office visits, we would do well to clarify our approach to its management that is distinct from the illnesses that cause it. Fever is a regulated elevation of body temperature, mediated by the anterior hypothalamus, which occurs in response to any insult that stimulates the body’s inflammatory defenses. Similar to a thermostat, the hypothalamic set point controls the temperature the body tries to maintain. Some provocation, in children most commonly a viral infection, induces macrophages to release cytokines that function as endogenous pyrogens. They circulate to the anterior hypothalamus, where they increase local levels of prostaglandin E2 and induce an increase in the set point. Several mechanisms then come into play to bring the core temperature (the temperature of blood within the pulmonary artery) up to the new set point. 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