Preoperative Flurbiprofen Axetil Research Articles

Preoperative flurbiprofen axetil administration for acute postoperative pain: a meta-analysis of randomized controlled trials.

Non-steroidal anti-inflammatory drugs have been shown to effectively decrease postoperative pain and reduce opioid requirements. Flurbiprofen axetil is an injectable non-selective cyclooxygenase inhibitor that has a high affinity for inflammatory tissues to achieve targeted drug therapy and prolonged duration of action. This meta-analysis examined the use of preoperative flurbiprofen axetil and its impact on postoperative analgesia. An electronic literature search of the Library of PubMed, Cochrane CENTRAL, and EMBASE databases was conducted in Feb 2016. Searches were limited to randomized controlled trials. The primary outcome was pain scores. The secondary outcomes included cumulative postoperative opioid consumption and opioid-related adverse effects. A total of nine RCT studies involving 457 patients were included in this study. Compared to patients without perioperative flurbiprofen axetil, patients treated with preoperative flurbiprofen axetil had lower pain scores at 2h (SMD -1.00; 95% CI -1.57 to -0.43, P=0.0006), 6h (SMD -1.22; 95% CI -2.01 to -0.43; P=0.002), 12h (SMD -1.19; 95% CI -2.10 to -0.28; P=0.01), and 24h (SMD -0.79; 95% CI -1.31 to -0.27; P=0.003) following surgery. Preoperative flurbiprofen axetil had no significant effect on postoperative opioid consumption (SMD -13.11; 95% CI -34.56 to 8.33; P=0.23). There was no significant difference between the groups with regard to adverse effects. Compared to patients with postoperative flurbiprofen axetil, however, preoperative flurbiprofen axetil resulted in decreased pain score only at 2h after operation. Preoperative use of flurbiprofen axetil will result in significantly lower postoperative pain scores, but no difference in nausea, vomiting, and opioid consumption compared to those who did not receive flurbiprofen axetil. However, more homogeneous and well-designed clinical studies are necessary to determine whether preoperative flurbiprofen axetil administration has more efficacy than that given at the end of surgery.

Effect of Preemptive Flurbiprofen Axetil and Tramadol on Transurethral Resection of the Prostate under Spinal Anesthesia.

Objective. To investigate the efficacy of preoperative intravenous flurbiprofen axetil and tramadol on spinal anesthesia for transurethral resection of the prostate (TURP). Methodology. In this prospective clinical study, we enrolled 60 patients undergoing TURP under spinal anesthesia with small-dose bupivacaine and sufentanil. Patients were randomly divided in two: group flurbiprofen axetil and tramadol (Group FT) intravenously received 1 mg/kg flurbiprofen axetil and 1 mg/kg tramadol 20 min prior to the surgical procedures and group control (Group C) was given normal saline. The characteristics of spinal anesthesia, blood pressure, heart rate, analgesic requirement, visual analogue scale (VAS), and overall satisfaction degree were collected. Results. Time to the first analgesic requirement was significantly longer in Group FT. Patients who needed postoperative analgesics were fewer in Group FT. VAS scores were lower in Group FT at postoperative time points of 1, 2, 6, and 12 h. The patients in Group FT were more satisfied than in Group C. Conclusions. Preoperative flurbiprofen axetil and tramadol can reduce and delay postoperative pain and then decrease analgesic consumption for TURP under spinal anesthesia without an increase of side effects.

Can preoperative flurbiprofen axetil reduce the total dose of fentanyl and sevoflurane for breast-conserving surgery?

Tokyo Women's Medical University Medical Center East, Department of Anaesthesiology and Intensive Care, Arakawa-ku, Japan

Preoperative intravenous flurbiprofen reduces tracheal extubation-induced adverse effects

Objective To assess whether preoperative intravenous administration of flurbiprofen, a non-steroidal anti-inflammatory drug, reduces tracheal extubation-induced adverse effects. Methods Sixty patients undergoing lumbar vertebra fixation with general anesthesia were randomly assigned to one of three groups (n＝20). Placebo (group C and group Post ) or flurbiprofen (group Pre ) was injected 30 min before surgery; and placebo (group C and group Pre) or flurbiprofen (group Post) was injected 30 min before surgery termination. Results Groups were comparable for age, weight, sex, operation duration, extubation time and intraoperative blood loss.The incidence of postoperative throatache in PRE group and POST group was respectively 2/25、6/25. RS in PRE group and POST group was respectively 0.51 ±0.31、1.52±0.51. The incidence of postoperative throatache and RS in control group was respectively 14/25、2.82±0.41. PRE group and POST group were apparently lower than control group(P＜ 0.05 ). There was significant defference in throat ache and RS between PRE group and POST group(P ＜ 0.05 ). BCS of PRE group and POST group was respectively 4.73±0.50、3.00±0. RSS of PRE group and POST group was respectively2.16±0.26、2.06±0.21. BCS and RSS of control group were respectively 2.21 ±0.42、1.46±0.25.RSS and BCS of PRE group and POST group were obviously higher than control group (P＜ 0.05 ). There was obviously defference of BCS between PRE group and POST group. Nausea and vomit were not found in three group. The increase values of cortisol and glucose of PRE group and POST group were lower than control group (P＜ 0.05). There was also remarkable defference between PRE group and POST group. Conclusion Pre-operative flurbiprofen axetil analgesia reduces tracheal extubation-induced adverse effect and improves recovery quality. Key words: Flurbiprofen; Preemptive analgesia; Extubation-induced side effects

Analgesic effectiveness of flurbiprofen axetil after uterine curettage on abortion: A randomized controlled trial

Summary Background Pain after uterine curettage has not been clearly evaluated. This study was designed to investigate the hypothesis that flurbiprofen axetil used prior to curettage on abortion could decrease 50% pain from uterine contraction. Methods Ninety seven ASA physical status I–II patients, undergoing elective uterine apoxesis, were allocated to this randomized double-blind controlled study and assigned into one of two groups ( n = 45). In the flurbiprofen group, patients received an i.v. injection of flurbiprofen 50 mg in 5 ml 10 min prior to propofol anesthesia. The control group received the same volume of saline injection. Morphine 0.04 mg/kg was used as the rescue drug for uncontrolled pain. Visual analog scale for analgesia at rest, satisfaction with analgesia, morphine consumption and side effects were recorded. Results A total of 87 patients completed the study. The intention-to-treat number of patients was 45 in each group. Flurbiprofen group evidenced effective analgesia (vs . saline P = 0.019), with better satisfaction ( P = 0.015), lower incidence of nausea, dizziness and drowsiness, pruritus, dry mouth and uterine bleeding than the saline control. The flurbiprofen group consumed less morphine in 1 h 0.6 mg (interquartile 0.1–1.2), vs . saline group 3.7 mg (interquartile 1.5–4.6) ( P = 0.049). The number of patients needed to treat was 2 in the flurbiprofen group. Conclusion Preoperative flurbiprofen axetil 50 mg is a clinically effective analgesic means after uterine curettage on abortion.

Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery

The aim of the study was to investigate postoperative analgesia and the opioid-sparing effect of the preoperative administration of intravenous flurbiprofen axetil in patients undergoing spinal fusion surgery. Thirty-six patients were randomly allocated into one of three groups. Group A received preoperative flurbiprofen axetil, 1 mg x kg(-1). Group B received postoperative flurbiprofen axetil, 1 mg x kg(-1). Group C received a placebo. All groups were given a standardized anesthesia and intravenous morphine via a patient-controlled analgesia device for postoperative analgesia. The pain score was evaluated by a visual analog scale (VAS) at 0 (T(0)), 1 (T(1)), 2 (T(2)), 6 (T(3)), 12 (T(4)), and 24 (T(5)) h after surgery, and the morphine requirement was recorded during the study period. VAS in group A was significantly lower than that in group B at T(0) and T(1). VAS in group A was significantly lower than that in group C throughout the time course after surgery. Postoperative morphine consumption in group A was significantly lower than that in groups B and C at T(0) to T(3). As compared with postoperative administration, preoperative administration of intravenous flurbiprofen axetil provides better postoperative analgesia and an opioid-sparing effect in patients undergoing spinal fusion surgery under general anesthesia.