Preoperative Diagnosis Of Gastrointestinal Stromal Tumors Research Articles

A radiomics-based model for differentiation between benign and malignant gastrointestinal stromal tumors

To establish a model for discrimination between benign and malignant gastrointestinal stromal tumors (GIST) by analyzing the texture features extracted from computed tomography (CT) images. The CT datasets were collected from 110 patients with GIST (including 80 as the training cohort and 30 as the validation cohort). Feature set reduction was executed with the 0.632 + bootstrap method in the initial feature set followed by stepwise forward feature selection in the feature subset, and the classification model was generated by logistic regression. The 6-texture-featurebased classification model successfully discriminated between benign and malignant GIST in both the training and validation cohorts with AUCs of 0.93 and 0.91, sensitivity of 0.88 and 0.87, specificity of 0.85 and 0.86, and accuracy of 0.87 and 0.86 in the two cohorts, respectively. This classification model established by radiomics analysis is capable of discrimination between benign and malignant GIST to provide assistance in preoperative diagnosis of GIST.

Robot-assisted resection of gastrointestinal stromal tumors (GIST): a single center case series and literature review.

Robotic techniques are claimed to be an alternative to laparoscopic and open approaches for gastrointestinal stromal tumors (GIST) treatment. Our aim is to present our single center experience and a literature review. From June 2012 to August 2014, six patients with preoperative diagnosis of GIST were treated by robotic surgery at Sanchinarro University Hospital. Two GIST tumors were localized in the second part of the duodenum, one in the first portion, two in the gastricantrum and another in the angular notch. Surgical procedures performed were two subtotal gastrectomies, one gastric wedge resection and three duodenal enucleations. None of the interventions needed conversion to open surgery. Mean operative time was 245 min (150-540). Mean hospital stay was 10.5 days (6-24). All lesions had microscopically negative resection margins. Mean follow-up was 24 months (8-33) with a disease-free survival rate of 100%. A robotic approach for GIST tumors is a safe and feasible procedure with a well-accepted oncological surgical result. Copyright © 2015 John Wiley & Sons, Ltd.

Gastrointestinal Stromal Tumor (GIST) Presenting as a Huge Pelvic Mass.

Gastrointestinal stromal tumors (GISTs) are rare tumors that can arise anywhere in the tubular gastrointestinal tract. These tumors occasionally present as a pelvic mass, leading to a misdiagnosis of gynecological disease. A 47-year-old woman presented with a pelvic mass measuring 30 cm in diameter and highly elevated CA-125 levels. She underwent exploratory laparotomy with resection of the pelvic mass. The mass mimicking ovarian malignancy was found in the sigmoid colon and was correctly diagnosed as a GIST at surgery. It should be noted that preoperative diagnosis of GIST is uncommon, due to its rarity and the varying clinical presentation. However, non-gynecological tumors should be included in the differential diagnosis of a pelvic mass with atypical presentation. Gynecologists need to be cognizant of extra-ovarian pathology in patients presenting with an atypical pelvic mass.

Gastrointestinal stromal tumor of the stomach: Evaluation and treatment in a poor-resource setting

Background: Gastrointestinal stromal tumors (GISTs) represent mesenchymal tumors arising from the gastrointestinal wall, mesentery, omentum, or retroperitoneum that express the c-kit proto-oncogene. In low-income countries, facilities for diagnosis are limited and the patients present late with large tumors. We present the evaluation and treatment of gastric GIST and highlight the difficulties in management of these patients in a setting of limited resources. Materials and Methods: We retrospectively reviewed patients who were managed for gastric GIST from January 2001 to December 2010 in the Department of Surgery, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. Information recorded included patient's demographic characteristics, clinical presentation, treatment, operative findings, and outcome. Results: There were 13 patients with histological diagnosis of gastric GIST. Their age ranged 31-67 years, with a mean of 48 years. All the patients were symptomatic and had palpable abdominal masses at presentation. Tumor size ranged 13.4-39.5 cm. Six patients had preoperative diagnosis of GIST, including two with immunohistochemical confirmation. Overall, seven patients had complete resection of their tumors. Four patients presented with gastric outlet obstruction and both peritoneal and liver metastasis. Five patients were on imatinib which they had taken for 3-13 months. Three patients had tumor recurrence 1-3 years after complete resection. Follow-up ranged from 1 month to 4.5 years. Five patients were followed up for more than 1 year. Conclusion: Due to lack of facilities for endoscopic ultrasound guided biopsy and immunohistochemistry, preoperative diagnosis was based on clinical and radiological features. Despite the large tumor size, complete resection is associated with good control of symptoms and prolonged survival.

A gastrointestinal stromal tumor presenting as a pelvic mass: A case report

Gastrointestinal stromal tumors (GISTs) represent 0.1-1% of gastrointestinal malignancies. They are commonly asymptomatic and found incidentally during laparoscopy, surgical procedures or radiological studies. Diagnosis is based on histology and immunohistochemistry, while the role of imaging studies is not diagnosis-specific. We present the case of a 38-year-old patient complaining of an increase in her abdominal circumference. Consequently, a vaginal examination, a transvaginal ultrasound and an MRI of the abdomen and pelvis were carried out. It should be noted that a preoperative diagnosis of GISTs is uncommon, due to the rarity and many presentations of the disease. Ultrasound and MRI are not able to differentiate a GIST from ovarian cancer. However, if a pelvic mass is detected, the possibility of a non-gynaecological tumor has to be considered.