PurposeTo assess intended parents’ preferences about expanded prenatal cell-free DNA (cfDNA) screening. MethodsA survey was administered to couples who were pregnant or trying to conceive. Partners within couples were independently asked about willingness to seek prenatal cfDNA screening for diseases and traits that varied by severity, treatability, age-of-onset, and reliability. Additional questions explored couples’ decision-making processes and how various factors would impact those decisions. ResultsRespondents (n=494) were most likely to seek a prenatal genetic test when the test is completely predictive (p-value of predictability effect=0.0116), for earlier onset (p-value of onset effect=0.0310), treatable diseases (p-value of treatability effect=0.0032), and of highest severity (p-value of severity effect <0.0001). Living in states where termination was not available was not associated with decreased interest in prenatal screening, with 45% reporting that it would make them more likely to seek testing. There was moderate concordance between couples about their testing decisions and the majority of pregnant persons (68.8%) and partners (66.7%) desired firm screening recommendations from their doctors. ConclusionThese data suggest that couples are highly information-seeking when presented with all testing options neutrally, but most desire to be presented with firm testing recommendations from their clinician.