Premalignant Lesions Of Uterine Cervix Research Articles

Compliance of Screening Implementation-related Factors and after Treatment of Cervical Precancerous Lesions

The purpose of this study was to investigate the compliance rate and related factors of follow-up after treatment for premalignant lesions of the uterine cervix. Data were collected retrospectively from medical records of 362 women who had received treatment for premalignant lesions of uterine cervix from 2009 to 2013 at P hospital in Y city, Korea. Participants were grouped into three groups by their compliance rate of follow-up: high 32.0%, moderate 45.3%, low 22.7%, respectively. The compliance rate of follow-up was statistically significant by education level and hormone therapy. Based on the results, systematic education about importance of follow-up will helpful to improve the compliance after treatment for premalignant Received (July 09, 2015), Review Request(July 10, 2015), Review Result(July 27, 2015) Accepted(August 19, 2015), Published(October 31, 2015) 626-815 Yangsan Busan National University Hospital, 50 Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do, Korea email: roseeui@hanmail.net (Corresponding Author) 626-870 College of Nursing, 49 Busandaehak-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do, Korea. email: jyha1028@pusan.ac.kr 626-815 Yangsan Busan National University Hospital, 50 Geumo-ro, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do, Korea email: mixbluemix@naver.com 609-735 College of Natural Sciences, 2, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan, Korea. email: choys@pusan.ac.kr Compliance of screening implementation-related factors and after treatment of cervical precancerous lesions Copyright c 2015 HSST 178 lesions of uterine cervix among women.

P53 and bcl2 expression in malignant and premalignant lesions of uterine cervix and their correlation with human papilloma virus 16 and 18

Background and Objective:Persistent high risk human papilloma virus (HPV) infection is probably the best predictor of increased risk of cervical cancer, but expression of certain markers of cell proliferation and apoptosis have been studied. The present study was conducted to evaluate the expression of p53 and bcl2 in premalignant and malignant lesions of cervix and its correlation with HPV type 16 and 18.Materials and Methods:The study comprised of 35 cases (including 24 prospective cases and 11 retrospective cases) of premalignant and malignant lesions of the cervix. Slides were stained with Hematoxylin and Eosin and p53, bcl2 (immunohistochemistry), HPV 16 and HPV 18 (in situ hybridization).Results:p53 positivity was seen in 8/19 (42.1%) cases of cervical intraepithelial neoplasia (CIN) and 8/16 (50%) cases of carcinoma cervix, the difference not significant statistically. The difference in bcl2 expression in CIN versus carcinoma cervix (84.21% vs. 43.75%) was statistically significant (P = 0.030). There was no significant difference between p53 and bcl2 expression and the stage and grade of the tumors. Seven out of 19 cases of CIN (36.84%) were positive for HPV 16/18 infection and 8/16 cases (50%) of carcinoma cervix were HPV positive (P = 0.628).Conclusions:No significant association was found between HPV 16/18 infection and p53 and bcl2 expression in premalignant and malignant lesions of uterine cervix. Although, bcl2 staining showed a significant difference between CIN and carcinoma cervix, a larger case series is required to assess the association between HPV infection and overexpression of p53 and bcl2 proteins in these lesions.