Preferred Choice Research Articles

Choice versus no choice: Practical considerations for increasing choices.

Choice involves engaging in a selection response when multiple options are concurrently available. Choices can be incorporated into many components of behavior-analytic treatment such as providing clients with a choice between multiple items, activities, or tasks. We reviewed the main characteristics of 38 behavior-analytic articles that compared choice and no-choice conditions. We coded the experimental arrangements of choice and no-choice conditions and analyzed potential factors affecting preferences for choice and no choice. The findings suggest that the sizing of alternatives from which to choose, the timing of choice opportunities, and the timing of the delivery of the chosen option varied across the studies. Furthermore, preferences for choice shifted with differential reinforcement history and response effort manipulations of choice or no choice. The findings suggest that individual variables should be considered when providing choices, but more research is needed.

Effects of risk information on pedestrian evacuation during fire emergencies: Virtual experiments and survey

In fire emergencies, pedestrians often face uncertainty about the safety of evacuation routes due to a lack of risk information, which makes the emergency evacuation highly challenging. Although risk information is crucial for effective evacuation, the effect of varying levels of risk information on fire evacuation remains insufficiently explored. This study aims to address this gap by investigating the influence of different levels of risk information on pedestrian evacuation through virtual experiments and survey. We conducted a series of multiplayer fire evacuation experiments in Minecraft. The risk information provided to pedestrians before evacuation was controlled at three levels: no risk information, partial risk information, and complete risk information, by giving different risk information cues. The results of experiments indicated that risk information can improve pedestrian evacuation efficiency during fire emergencies, while more complete risk information can further improve pedestrian evacuation efficiency. Additionally, an information transfer phenomenon was observed during fire evacuations, in which pedestrians adjusted their behaviour based on perceived fire, leading others to avoid the fire in advance. The analysis of pedestrian behaviour revealed that pedestrians did not exhibit imitative behaviour in evacuation direction choices during fire emergencies. Pedestrian route choices were significantly influenced by the initial distance of pedestrians relative to the exits. Moreover, complete risk information cues did not significantly influence pedestrians’ route choices compared with partial risk information cues. A post-experimental survey was conducted to assess pedestrians’ route choice preferences under different risk information cue scenarios. The results showed that pedestrians preferred the nearest route.

Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa.

Adolescence is a critical developmental period for the study of anorexia nervosa (AN), an illness characterized by extreme restriction of food intake. The maturation of the reward system during adolescence combined with recent neurobiological models of AN led to the hypothesis that early on in illness, restrictive food choices would be associated with activity in nucleus accumbens reward regions, rather than caudate regions identified among adults with AN. Healthy adolescents (HC, n = 41) and adolescents with AN or atypical AN (atypAN, n = 76) completed a Food Choice Task during fMRI scanning. Selection of high-fat foods and choice-related activation in nucleus accumbens and anterior caudate regions-of-interest (ROIs) were compared between individuals with AN/atypAN and HC. Associations were examined between choice-related activation and choice preferences among the AN group. Exploratory analyses examined associations between choice-related activation and psychological assessments among the patient group. Adolescents with AN or atypAN selected fewer high-fat foods than HC (t = -5.92, p < .001). Counter to predictions, there were no significant group differences in choice-related activation in the ROIs. Among individuals with AN or atypAN, choice-related neural activity in the anterior caudate was significantly negatively associated with high-fat food selections in the task (r = -.32, p = .024). In exploratory analyses, choice-related anterior caudate activation was positively associated with psychological measures of illness severity among patients (p's < .05, uncorrected). In this large cohort of adolescents with AN/atypAN, there was no evidence of altered reward system engagement during food choice. While there was no group difference in choice-related caudate activation, the associations with choices and psychological measures continue to suggest that this neural region is implicated in illness. Longitudinal analyses will clarify whether neural variability relates to longer-term course.

Natural or organic? How framing impacts choices of sustainable food and wine products

PurposeThe paper investigates the choice preferences of Gen Z individuals between products labelled as “organic” versus products labelled as “natural”. While the former category guarantees production standards set by EU legislation, no codified standard exists for natural products. Understanding whether consumers value the difference is important for policy and marketing reasons.Design/methodology/approachThe paper uses a between-subject laboratory experiment. Participants are undergraduate students from a medium-sized university, randomized into two conditions. In both conditions, individuals choose between a conventional product and a sustainable one. In the first condition, we frame the organic product as “organic”. In the second condition, we frame the same organic product as “natural”. We always refer to the conventional product as “conventional”. This methodology is applied to a choice regarding wine and a choice regarding food. Choices are incentive-compatible, as one participant is randomly selected in each session to receive the chosen product.FindingsWe find no significant difference between the frequency of choices of the product framed as organic and the one framed as natural, neither for wine nor for food.Originality/valueThe paper tests in a controlled and incentivized laboratory experiment the choice differences regarding products framed as organic versus products framed as natural. The results provide policymakers and marketers with a better understanding of the effects of sustainability labelling on consumer behaviour. The policy implications of our results, which we discuss in the paper, are relevant and multifaceted.

Urban-rural differences in preferences for traditional Chinese medicine services among chronic disease patients: a discrete choice experiment

BackgroundWith the increasing prevalence of chronic diseases, the demand for medical services from chronic disease patients has become diversified and personalized. The advantages and role of traditional Chinese medicine in the prevention and treatment of chronic diseases gradually emerging. The preferences and willingness to pay for traditional Chinese medicine services (TCMS) among patients with chronic diseases, as well as any disparities between urban and rural patients, have not been examined in past studies.ObjectiveThis study aimed to investigate the preferences of chronic disease patients for TCMS, explore the value/importance that patients place on different treatment attributes, and evaluate whether there are urban-rural differences in their preferences and willingness to pay for TCMS.MethodsA total of 317 patients from Jiangsu Province, China participated in a discrete choice experiment that elicited the preferences for TCMS. The choice questions were constructed by six attributes: out-of-pocket (OOP) cost, institution, medical provider, treatment method, treatment duration, treatment efficacy. Mixed logit models were used to estimate the stated preference and marginal willingness to pay for each attribute.ResultsThe choice preferences of chronic disease patients for TCMS in this study were influenced by the four attributes: institution, treatment method, and treatment efficacy, and OOP cost. Improvements in treatment efficacy were the most concerning, followed by being treated in traditional Chinese medicine (TCM) hospital. Patients were willing to pay more to get better treatment outcomes. Compared with primary care institutions, patients were willing to pay more for treatment in TCM hospitals. The preferences for economic attribute (OOP cost) varied between urban and rural areas, and rural patients tended to favor scenarios that imposed a lower economic burden on them.ConclusionThe chronic disease patients’ preferences for TCMS were determined mainly by treatment efficacy but also by institution, treatment method and OOP cost. The urban-rural difference in preference identified in this study highlights that effective policy interventions should consider the characteristics of patients’ demand in different regions.

Choice of alcohol over a natural reward: an experimental study in light and heavy social drinkers.

A core symptom of alcohol use disorder (AUD) is a progressively increased choice of alcohol over alternative rewards despite negative consequences. Here, we investigated choice between personalized alcohol vs. natural rewards in a laboratory setting, and compared this behavior between non-treatment-seeking heavy drinkers and light social drinkers. 30 light social drinkers (15 men drinking < 15 drinks/week and 15 women drinking < 10 drinks/week) and 30 heavy, non-treatment-seeking drinkers (drinking more than these levels; 15 women). In the Concurrent Choice Alcohol Food (CCAF) task, participants chose between individually tailored images of alcohol and snack rewards and collected points towards the respective reward. To assess cost sensitivity, points associated to the images varied so that they favored alcohol or snack, or were equal, creating three relative point levels. Choice preference for alcohol was strongly correlated with Alcohol Use Disorder Identification Test (AUDIT) scores, supporting the external validity of the choice procedure. Compared to light drinkers, heavy drinkers showed increased choice preference for alcohol, as indicated by a between-group difference in points of subjective equality, a metric that quantifies the relative point level at which alcohol and snacks were equally likely to be chosen. In both groups, choice preference strongly depended on the relative point level of alcohol compared to snacks, suggesting that responding for alcohol in heavy drinkers was sensitive to costs. Our results replicate previous findings of a relationship between self-reported alcohol use and choice preference for alcohol. We also found that choice behavior was strongly dependent on relative cost of alcohol in both groups, although price sensitivity was lower in heavy compared to light drinkers. An increased choice preference for alcohol in heavy drinkers suggests that they attribute a higher relative reinforcing value to alcohol compared to natural rewards.

The delapril-indapamide combination in treatment of arterial hypertension: practical implications in light of the new guidelines.

The recent guidelines issued by the European Society of Hypertension reaffirmed that the degree of control of hypertension remains suboptimal worldwide. In order to increase the proportion of well-controlled patients, in addition to nonpharmacological measures, it is necessary to improve the implementation of drug therapy in the clinical practice as much as possible. Initial therapy should almost always be based on the combination, free or fixed, between ACE inhibitor drugs, or direct angiotensin II inhibitors ('sartans') and diuretics (thiazide or thiazide-like) or calcium channel blockers at the maximum recommended and well-tolerated dose. The combination of the thiazide-like diuretic indapamide with the ACE inhibitor delapril has shown, based on numerous clinical trials and meta-analyses, very good results in terms of antihypertensive efficacy, tolerability, and prevention or regression of organ damage. Indapamide is a thiazide-like diuretic also endowed with direct vasodilator effect and long duration of action. A meta-analysis of 19 randomized clinical trials demonstrated a greater reduction in the incidence of cardiac events, stroke and heart failure with thiazide-like diuretics than with thiazide diuretics. Delapril is a non-sulfhydryl ACE-inhibitor with high affinity for converting enzyme at the cardiac, pulmonary, and peripheral vascular levels. Being strongly lipophilic, delapril inhibits the ACE enzyme at the tissue level more potently than other ACE inhibitors. A peculiar feature of delapril is its weak bradykinin-enhancing effect due to its higher affinity for the C site than the N site of ACE, resulting in a lower incidence of cough and angioneurotic edema compared with other ACE inhibitors. In some meta-analyses, the pressor reduction was statistically, greater with the delapril-indapamide combination than with combinations between hydrochlorothiazide and ACE inhibitors. The combination consists of divisible tablets containing 30 mg delapril and 2.5 mg indapamide, and its pharmacological and clinical properties are not affected by simultaneous food intake. The antihypertensive efficacy of the combination, as well as its components, persists for the entire 24 hours. The recent alarming reports on the incidence of skin cancer during treatment with hydrochlorothiazide should also be a guide in clinical practice toward the preferential choice of a thiazide-like diuretic such as chlorthalidone or indapamide to replace hydrochlorothiazide.

318 - Examining the Impact of Intermittent Self-Catheterization on Quality of Life and Catheter Choice Preferences: Insights from the Continence Care Registry

318 - Examining the Impact of Intermittent Self-Catheterization on Quality of Life and Catheter Choice Preferences: Insights from the Continence Care Registry

A multi-stage game framework for new route promotion: Behavioral strategy and dynamic evolution of shippers, carriers, and governments

New freight routes are being planned and emerging globally, but often rely on government subsidies to enhance their competitiveness during the initial promotional phase. This study proposes a multi-stage game framework to explore the influence mechanism of behavioral strategies among three stakeholders: shipper, carrier, and government. Based on the assessment of shippers’ route choice preferences, we examine the dynamic evolution of carriers’ and governments’ behavioral strategies in the practical context of bounded rationality and dynamic learning. We theoretically derive the evolutionary paths and stable outcomes of dynamic systems across eight scenarios encompassing all the possible practical values to be taken, which provide broader and more valuable decision support for new route promotion. Finally, the feasibility and validity of the proposed model are verified by the actual case of the New International Land-Sea Trade Corridor. The findings indicate that government subsidies are not always effective and provide a precise subsidy range that can incentivize carriers to switch to the new route. Moreover, the study clarifies the impact of key factors such as subsidy, tax, route reliability, transportation time, and time value of cargo on the promotion of new routes through numerical simulation, and provides feasible management recommendations for government and route operations.

Susceptibility of Capsicum varieties to Thaumatotibia leucotreta (Lepidoptera: Tortricidae) infestation for production optimization.

Thaumatotibia leucotreta Meyrick (Lepidoptera: Tortricidae) is a major threat to the production and marketing of pepper (Capsicum spp.) in Ghana. To reduce the damage of the pest on pepper farming, it is important to find appropriate control methods, which may include the use of resistant host plants. This study investigated the relative susceptibility of 6 pepper varieties commonly cultivated in Ghana: Legon 18, Bird's eye, Scotch bonnet, Cayenne, KA2, and sweet pepper (Yolo wonder+ variety). Choice and no-choice ovipositional preference tests were conducted and the population growth rate of T. leucotreta was determined by establishing life table parameters including the net reproductive rates (R0), the mean generation time (G), intrinsic rate of natural increase (rm), the population doubling time (T), and the finite rate of increase (λ). In the no-choice test, females exhibited oviposition preference for sweet pepper (12.08 eggs/fruit), while Bird's eye was the least preferred (5.00 eggs/fruit). The same results were observed in the choice test. However, the population growth rate of T. leucotreta was highest on the Scotch bonnet and Cayenne, with rm of 0.124 and 0.127, respectively, while the Bird's eye and sweet pepper recorded the least rm of 0.116. Thus, the tested varieties had varying levels of susceptibility to T. leucotreta infestation. Bird's eye was the least susceptible variety, while Cayenne and Scotch bonnet were the most susceptible varieties. These findings could direct farmers on the choices of pepper varieties for cultivation and proffer potential opportunities to breed new varieties resistant to T. leucotreta infestation.

Динамика карьерных ориентаций будущих педагогов: результаты межвузовского исследования

One of the reasons for the shortage of teaching staff in various countries around the world is the problem of attracting young staff to schools and their rapid dismissal. This situation actualizes the issues of studying the motivational bases for choosing a teaching profession. Tracking changes in students' career choice preferences can be facilitated by monitoring students' career orientations at different stages of their studies. The study aims to explore the dynamics of career orientations of student teachers from universities of various types over a three-year period of study. As a method of repeated research, the methodology for determining career orientations by Shein (adapted by Vinokurova and Chiker) was used. Analysis of the universities’ curricula was carried out to determine the characteristics of the educational process organization. With the help of a questionnaire, socio-demographic and motivational-professional characteristics of students were identified. Five hundred and four 3rd-year students from 6 universities of different types, who had already taken part in the first stage of the study in 2022, became participants in this study. The analysis of the obtained data allowed to identify the preservation of main career orientations (service, job stability and integration of lifestyles) among students. The convergence of the indicators of career orientations among students from different universities was established.

Robust optimization of train timetables with short-length and full-length services considering uncertain passenger volume and service choice behavior

Train timetables with a combination of short-length and full-length services can adapt to spatial and temporal variations in demand. However, with such timetables, some passengers may choose to catch an earlier short-length service and then transfer to a full-length service to reach their destinations rather than waiting for a crowded full-length service. This uncertain service choice behavior frequently occurs, which, however, was not well considered in most studies on demand-oriented timetabling. Therefore, this study presents a robust timetabling approach based on the scenario-based method considering uncertain passenger volumes and service choice behavior for choosing different types of train services. A customized decomposition-based method with an iterative solution procedure is designed to solve the proposed model. In each iteration, a multi-agent-based simulation algorithm is developed to update passengers’ travel utility and the service choice preference proportion based on the previous iteration’s timetabling results. To obtain high-quality solutions in an acceptable computing time, a hybrid “ALNS + GUROBI” algorithm is developed to handle the timetabling problems for large-scale cases. The proposed method optimizes the train timetables for Xi’an Metro Line 3 in China. Our results indicate that the proposed method can account for uncertain passenger volumes and service choice behavior by adjusting the short-length plans and train headways to match the transport capacity to passenger demand.

Double-edged sword of industrial internet of things: Empirical evidence from green transformation of enterprises

The industrial revolution based on the Internet of Things brings new opportunities and challenges for enterprises' green and sustainable development. Therefore, this study explores the relationship between the Industrial Internet of Things (IIOT) and the Green Transformation of Enterprises (GT) based on the data of China's A-share listed companies from 2009 to 2023 using two-way fixed, mediated effect, and moderated effect models. The results show that for every unit increase in IIOT, the GT increases by 28.89 percent on average, indicating that IIOT can break down information barriers and effectively promote GT. However, after disaggregating the GT, it was found that the IIOT guided companies to implement the Symbolic Green Transformation (SGT) instead of adopting the Realistic Green Transformation (RGT). This strategic choice preference is more pronounced among firms that are larger, in energy-intensive industries, in regions with weaker environmental regulations and higher levels of development. The intermediary mechanism test proved that the IIOT can drive firms to implement comprehensive GT through paths that enhance investment attractiveness, productivity, technological innovation, and pay gaps. In particular, the masking effect reminds us that smart technology is a “double-edged sword”. The negative effects of smart technologies hinder the implementation of RGT. Further analysis reveals an inverted U-shaped relationship between IIOT and RGT preferences. In addition, in companies that focus on Environmental, Social and Governance (ESG) performance and avoid financial speculation, the dark side of intelligent technology is suppressed. The findings of this study enrich the research scope of smart technology, GT, and provide important insights for enterprises in emerging economies to rationally utilize IIOT to seek green and sustainable development under the wave of rapid development of smart technology.

The Role of the Rat Prefrontal Cortex and Sex Differences in Decision-Making.

The prefrontal cortex is critical for decision-making across species, with its activity linked to choosing between options. Drift Diffusion Models (DDMs) are commonly employed to understand the neural computations underlying this behavior. Studies exploring the specific roles of regions of the rodent prefrontal cortex in controlling the decision process are limited. This study explored the role of the prelimbic cortex (PLC) in decision-making using a two-alternative forced-choice task. Rats first learned to report the location of a lateralized visual stimulus. The brightness of the stimulus indicated its reward value. Then, the rats learned to make choices between pairs of stimuli. Sex differences in learning were observed, with females responding faster and more selectively to high-value stimuli than males. DDM analysis found that males had decreased decision thresholds during initial learning, whereas females maintained a consistently higher drift rate. Pharmacological manipulations revealed that PLC inactivation reduced the decision threshold for all rats, indicating that less information was needed to make a choice in the absence of normal PLC processing. Mu opioid receptor stimulation of the PLC had the opposite effect, raising the decision threshold and reducing bias in the decision process towards high-value stimuli. These effects were observed without any impact on the rats' choice preferences. Our findings suggest that PLC has an inhibitory role in the decision process and regulates the amount of evidence that is required to make a choice. That is, PLC activity controls "when", but not "how", to act.Significance Statement This study reports causal evidence for a part of the rat prefrontal cortex, the prelimbic cortex, in controlling the amount of information needed to make a choice. Results were based on reversible inactivation using the GABA-A agonist muscimol and by stimulation of mu opioid receptors using intra-cortical infusions of the selective mu agonist DAMGO. We also found evidence for a sex difference in learning and performing a visually guided two-alternative forced-choice task. Drift Diffusion Models found that females had stable decision processes throughout learning, and showed a persistent bias against the lower value option. By contrast, males exhibited changes in their decision processes, notably reducing the amount of information needed to make choice over the period of early choice learning.

Eye-tracking technology in Vietnam: A comprehensive review of its application and acceptance across various fields

This paper presents a literature review of the application and acceptance of eye tracking technology in Vietnam across various fields, including education, consumer behavior, and medical research. Eye tracking has gained prominence due to its ability to provide objective insights into visual attention, cognitive processes, and decision-making. The study aims to evaluate the scope of existing research, assess the technology's effectiveness in Vietnamese contexts, and highlight areas for future development. The review focuses on research published up to 2023, specifically on studies that utilized eye tracking technology to explore various research areas. A systematic search using relevant keywords in both English and Vietnamese was conducted across academic databases. Initially, nine relevant articles were identified, with four selected for detailed examination. These studies applied eye tracking technology to different domains, such as consumer behavior, gender differences, environmental influences on children, and brand awareness. For instance, research in consumer behavior used eye-tracking to investigate Vietnamese preferences in food and beverage choices. Meanwhile, studies focusing on dioxin exposure in children explored gender-specific visual patterns and cognitive effects. These findings suggest that eye tracking is a valuable method for examining consumer preferences and environmental impacts on cognitive behavior, especially in Vietnam. However, this review also identifies limitations in the existing research, particularly regarding sample representation and diversity. To advance the field, future research should focus on including more diverse populations and integrating additional physiological measures. This would provide a more comprehensive understanding of human behavior in Vietnam, thereby enhancing the applicability and relevance of eye tracking studies across various disciplines. Addressing these limitations could significantly contribute to the growth and development of research using eye tracking technology in Vietnam.

Exploring uncharted digital horizons: Role of internet self-efficacy in shaping the destination preferences of senior tourists

The senior tourist market is expanding due to longer lifespans, yet there is insufficient research on their preference for holiday choice, especially in the digital era. This study investigated the influence of internet self-efficacy on destination choice preferences among senior tourists. Through five experiments, we discovered that higher levels of internet self-efficacy among seniors led to a pronounced preference for desirability, whereas those with lower levels were inclined towards feasibility. This effect is mediated by the sense of autonomy that internet self-efficacy instills. This inclination holds true only for seniors with a fixed (vs. growth) mindset and when they travel with an incompetent (vs. competent) companion. These findings significantly contribute to the empirical investigation of senior tourist decision-making in the digital environment, providing valuable empirical insights for practitioners seeking to target the senior market.

Attribute commensurability and context effects in preferential choice.

Context effects in multi-alternative, multi-attribute choice are widely documented, but often elusive. We show that this elusiveness can arise in part from the way that choices are presented. To illustrate this, we use a modeling framework to predict how changes to the format of attribute values, specifically the commensurability of attribute values, influences attention allocation and consequently context effects. Guided by this framework, we show in two online choice experiments (total N = 954 adults) that manipulating the commensurability of attributes leads to different patterns of context effects. Robust attraction and compromise effects are found when attributes are incommensurable (e.g., CPU speed in GHz and RAM memory in GB, or quality ratings on different scales), and mostly null effects occur when attributes are commensurable (e.g., quality ratings on the same scale). Our findings show how the format of choice information can substantially alter the integration of that information and resulting choice patterns.

Respecting priorities versus respecting preferences in school choice: When is there a trade-off?

A classic trade-off that school districts face when deciding which matching algorithm to use is that it is not possible to always respect both priorities and preferences. The student-proposing deferred acceptance algorithm (DA) respects priorities but can lead to inefficient allocations. We identify a new condition on school choice markets under which DA is efficient. Our condition generalizes earlier conditions by placing restrictions on how preferences and priorities relate to one another only on the parts that are relevant for the assignment. Whenever there is a unique allocation that respects priorities, our condition captures all the environments for which DA is efficient. We show through stylized examples and simulations that our condition significantly expands the range of known environments for which DA is efficient. We also discuss how our condition sheds light on existing empirical findings.

Preferences for diagnostic pathways and treatment choice in systemic lupus erythematosus: a patient-based discrete choice experiment.

Starting from the unmet need of early diagnosis and treatment in systemic lupus erythematosus (SLE), the study aims to explore patient preferences in diagnostic pathways and treatment modalities. It seeks to integrate clinical priorities with patient perspectives, providing an optimal approach to SLE treatment that remains uncertain. A discrete choice experiment (DCE) has been conducted to investigate whether patient preferences align while maintaining consistent attributes and levels, providing a direct assessment of relative preferences and hypothetical treatment approaches in SLE. DCE results demonstrated that obtaining an early diagnosis is the most crucial attribute for patients. Additionally, a multidisciplinary care team, capable of enhancing clinical outcomes and patient satisfaction, is essential, along with a clinical centre conveniently located within 30 minutes of the patient's home. Lastly, patients prefer the opportunity to reduce glucocorticoid to a dosage ≤5 mg/day, and eventually discontinue, aligning with the new EULAR recommendations, and favour oral and subcutaneous routes of administration for new course of treatment. Patient preferences contribute to enhancing the care pathway for SLE by optimising disease management, with a focus on multidisciplinarity and psychological support.

MTORC1 pathway activity biases cell fate choice

Pluripotent stem cells can differentiate into distinct cell types but the intracellular pathways controlling cell fate choice are not well understood. The social amoeba Dictyostelium discoideum is a simplified system to study choice preference as proliferating amoebae enter a developmental cycle upon starvation and differentiate into two major cell types, stalk and spores, organised in a multicellular fruiting body. Factors such as acidic vesicle pH predispose amoebae to one fate. Here we show that the mechanistic target of rapamycin complex 1 (mTORC1) pathway has a role in cell fate bias in Dictyostelium. Inhibiting the mTORC1 pathway activity by disruption of Rheb (activator Ras homolog enriched in brain), or treatment with the mTORC1 inhibitor rapamycin prior to development, biases cells to a spore cell fate. Conversely activation of the pathway favours stalk cell differentiation. The Set1 histone methyltransferase, responsible for histone H3 lysine4 methylation, in Dictyostelium cells regulates transcription at the onset of development. Disruption of Set1 leads to high mTORC1 pathway activity and stalk cell predisposition. The ability of the mTORC1 pathway to regulate cell fate bias of cells undergoing differentiation offers a potential target to increase the efficiency of stem cell differentiation into a particular cell type.