Preferred Choice Research Articles

Exploring Collocational Patterns and Genres: An Analysis of the Use of Poisonous and Venomous in American English

This research study explores the usage differences between the synonymous adjectives poisonous and venomous. Based on the Corpus of Contemporary American English (COCA), comprising over one billion words, representing American English from 1990 to 2023 across eight genres, i.e., spoken language, fiction, magazines, newspapers, academic texts, webpages, weblogs, and TV/movie subtitles, this study investigates the distribution of both synonyms across genres and their collocational patterns. This study addresses: 1) the distribution of poisonous and venomous across genres, and 2) common noun collocates of these synonyms. The findings reveal both adjectives are prevalent in informal contexts, such as fiction and magazines. However, distinct collocational preferences emerge in that poisonous aligns with nouns related to gases, chemicals, substances, and food, while venomous is usually combined with nouns denoting actions, emotions, and food items. This study highlights the interplay among lexical choice, formality, and collocational preferences in English.

Dissecting the sustainable tourist experience: sustainable consumption theory and co-creation theory approach

PurposeTourists are increasingly co-creating meaningful experiences and demonstrating a growing preference for sustainable travel choices. In response, this study investigates the co-created sustainable tourist experience in the Bahamas.Design/methodology/approachDrawing on sustainable consumption theory and co-creation theory, it aimed to develop a more comprehensive framework that encompasses the entire spectrum of the sustainable tourist experience. Data from 25 in-depth interviews and participant observation were analyzed using an inductive-deductive method.FindingsThe analysis revealed multiple aspects of sustainable tourist experience, including sustainable consumption dimensions (environmental, social/individual, social/interactive, economic and institutional) and co-creation phases (co-production, value-in-use and co-creation), along with travel stages (pre-trip, on-site and post-trip). Based on these insights, this study developed a framework that delineates the mechanism of sustainable tourist experience.Practical implicationsThis study outlines managerial implications for the tourism and hospitality industry, highlighting sustainability as central to the tourist experience. Destination planners are encouraged to promote sustainable initiatives that align with tourists’ desires to co-create experiences, enhancing satisfaction, supporting destination sustainability and contributing to long-term industry viability.Originality/valueThe findings contribute to existing research on co-created, across-stage sustainable tourist experiences by presenting a holistic framework that elucidates the underlying mechanisms. This study extends existing conceptual studies by offering a deeper understanding of how tourists interact and co-create with destinations, emphasizing the need to integrate sustainability more effectively into the tourist experience across all stages of travel.

SK609, a novel dopamine D3 receptor agonist and norepinephrine transporter blocker with putative pro-cognitive actions, does not induce psychostimulant-like increases in risky choice during probabilistic discounting.

Psychostimulants, such as amphetamine (AMPH) and methylphenidate (MPH), non-selectively elevate extracellular concentrations of the catecholamine neurotransmitters, dopamine (DA) and norepinephrine (NE), and are common pharmacological strategies used to improve prefrontal cortex (PFC)-dependent cognitive dysfunction. However, this approach can be problematic given AMPH has been shown to increase preference for risky choices in a rodent assay of risk/reward decision making. SK609 is a novel NE reuptake blocker that selectively activates DA D3 receptors without affinity for the DA transporter. SK609 has been shown to improve cognitive performance without increasing psychostimulant-like spontaneous locomotor activity, suggesting SK609 may benefit neurocognitive function without psychostimulant-like side effect liability. We compared AMPH, MPH, and SK609 within dose ranges that display their cognitive enhancing properties in a probabilistic discounting task (PDT) of risk/reward decision making behavior to assess their potential to increase risky choice preference. Rats chose between small/certain rewards delivered with 100% certainty and large/risky rewards delivered with descending probabilities across a session (100 - 6.25%) following administration of AMPH (0.25-1mg/kg), MPH (2-8mg/kg), and SK609 (4mg/kg). AMPH and MPH increased risky choice behavior at doses previously reported to enhance cognition, whereas SK609 did not. AMPH and MPH also reduced sensitivity to non-rewarded risky choices. These data highlight the combination of NE transporter blockade and selective D3 activation in pro-cognitive action without psychostimulant-like side effect liability. The absence of DA transporter blockade and non-selective dopaminergic activation are beneficial properties of SK609 that differentiates it from the traditional pro-cognitive psychostimulants.

Practitioner preferences in the analysis of cremation deposits in archaeology and biological anthropology: An overview of current osteoarchaeological practices with a focus on sex estimation.

Osteological data, such as biological sex, constitute a base for research in paleodemography and palaeopathology, as well as for understanding past socio-cultural practices. Despite extensive research efforts concerning cremated human remains over the past decades, an internationally acknowledged, standardized osteological protocol is not fully agreed upon. Furthermore, assessing cremation research practices from the literature is challenging because analysis reports are often written in the national languages of practitioners, which makes them difficult to access by an international audience. This study addresses this gap by directly reaching out to experts working with cremated human remains through an online questionnaire in Lime Survey. The aim is to identify and characterize patterns in cremation analysis practices. A particular emphasis was put on the methods of biological sex estimation. While the significance of these data is widely acknowledged, the ways in which they are obtained in practice are seldom examined. The results of this survey reveal an absence of standardization in protocols of analysis, and data collection, as well as in reporting on the cremated remains in publications and reports. Notably, the findings reveal regional preferences in methodological choices and inconsistent institutional training. A majority of respondents expressed a preference for traditional morphological methods over recently published metric and alternative methods for sex estimation. These variations underscore the complexity of establishing standardized cremation analysis protocols and highlight the importance of considering regional contexts and training in shaping future research practices.

Effects of risk information on pedestrian evacuation during fire emergencies: Virtual experiments and survey

In fire emergencies, pedestrians often face uncertainty about the safety of evacuation routes due to a lack of risk information, which makes the emergency evacuation highly challenging. Although risk information is crucial for effective evacuation, the effect of varying levels of risk information on fire evacuation remains insufficiently explored. This study aims to address this gap by investigating the influence of different levels of risk information on pedestrian evacuation through virtual experiments and survey. We conducted a series of multiplayer fire evacuation experiments in Minecraft. The risk information provided to pedestrians before evacuation was controlled at three levels: no risk information, partial risk information, and complete risk information, by giving different risk information cues. The results of experiments indicated that risk information can improve pedestrian evacuation efficiency during fire emergencies, while more complete risk information can further improve pedestrian evacuation efficiency. Additionally, an information transfer phenomenon was observed during fire evacuations, in which pedestrians adjusted their behaviour based on perceived fire, leading others to avoid the fire in advance. The analysis of pedestrian behaviour revealed that pedestrians did not exhibit imitative behaviour in evacuation direction choices during fire emergencies. Pedestrian route choices were significantly influenced by the initial distance of pedestrians relative to the exits. Moreover, complete risk information cues did not significantly influence pedestrians’ route choices compared with partial risk information cues. A post-experimental survey was conducted to assess pedestrians’ route choice preferences under different risk information cue scenarios. The results showed that pedestrians preferred the nearest route.

Parental influence on career choice in Jos North Islamic Secondary Schools, Nigeria

This study sought to analyzed parental influences on career choice in Jos North Islamic secondary schools. A sample of ten schools was selected using simple random sampling technique and total of 323 student participated in the research. The data obtained was analyzed using descriptive and inferential statistics. The result shows that there is positive but non-significant relationship between parental religiosity and career choice of their children. The result also reveals that there is positive and significant relationship between parental socio-cultural and economic influences and their children career choices at 5% and 10% significant level respectively. The study recommends the need to uplift career counseling unit in Islamic secondary schools. It also recommends the development of good relationship between parent and school counsellors towards guiding the students to Islamic career choice preference.

Commuter choice of UAM-friendly neighborhoods

Urban Air Mobility (UAM) which provides swift intra- and intercity transportation services has the potential to induce shifts in individuals’ commuting and residential decisions. It is anticipated that, in residential areas, UAM services would enhance accessibility for residents. An UAM-friendly neighborhood represents a novel, integrated neighborhood concept that provides the infrastructure and travel environment required to facilitate UAM services, thereby promoting sustainable neighborhood development and improving accessibility. To gain a deeper understanding of commuters’ choice behavior in UAM-friendly neighborhoods, we designed a stated choice experiment. Using data collected in Beijing city, we estimated a mixed logit model with interaction effects to identify the choice preferences of different people while capturing the unobserved preference heterogeneity. We found that individuals generally prefer to reside in such neighborhoods where the access distance to UAM vertiports is within one kilometer, the parking fee is either low (5 yuan/day) or free, the commuting time by UAT is 15 min, and drone window-docking delivery services are available. Households with high incomes (>400,000 yuan/year) and those owning a car are likely to adopt these novel neighborhoods. There is a varying degree of heterogeneity observed regarding residential location and distance to UAM vertiports among individuals in different age groups. Results of the elasticity analysis indicate that UAT commuting cost has the greatest impact on the likelihood of residing in UAM-friendly neighborhoods.

Is Bündnis Sahra Wagenknecht A New Alternative for Populist Voters?

Abstract In just five months, Bündnis Sarah Wagenknecht (BSW) progressed from its foundation to winning six seats in the European Parliament. Research has indicated that the party has significant potential, particularly among voters of Germany’s two populist parties: Alternative for Germany (AfD) and Die Linke. Since BSW is also classified as a populist party, this article explores the extent to which populist attitudes influence the vote choice preference for BSW. The analysis employs a three-dimensional populism scale, using data from a VAA-like website. The results reveal that voters intending to vote for BSW exhibit strong anti-elitist and people-centric views, but do not hold Manichean outlooks. This positions BSW voters ideologically between Die Linke and AfD voters in terms of populist ideation – albeit closer to the AfD, reflecting the party-level populism of BSW. Additionally, populist attitudes, particularly anti-elitism, are significant predictors of vote-switching from other parties to BSW.

Comparative Outcomes of En-Bloc Holmium Laser Enucleation of the Prostate and Transvesical Robot-Assisted Simple Prostatectomy for the Management of Benign Prostatic Hyperplasia: A Propensity-Matched Analysis.

Background: Holmium laser enucleation of the prostate (HoLEP) and robot-assisted simple prostatectomy (RASP) have emerged as the two surgical treatments of medication-refractory benign prostatic hyperplasia (BPH). The comparative outcomes of en-bloc HoLEP with early apical release and RASP with modified Freyer's technique remain unexplored. Methods: Between 2018 and 2022, patients with medication-refractory BPH and prostate volume ≥80 g underwent HoLEP or RASP depending on clinical characteristics, patient choice, and surgeon preference. A 1:1 propensity-matched analysis was performed with prostate volume and preoperative International Prostate Symptom Score (IPSS) as the matching variables to eliminate selection bias. Trifecta outcome was defined as complete urinary continence, Qmax >15 mL/second, and no postoperative complications at 3 months. After an initial univariable analysis to predict factors associated with the trifecta outcome, variables with significance levels of ≤0.1 were included in a multivariable model. Results: Of 416 patients with medication-refractory BPH, 158 underwent HoLEP, whereas 258 underwent RASP. Following matching, 80 patients in each group were included in the analysis. There was no difference in the median postoperative IPSS score, median postoperative Qmax, and continence rate at 3 months. The percentage of patients who attained the trifecta outcome in the HoLEP and RASP groups was 71.25% and 63.75%, respectively (p = 0.4). Patients in the HoLEP group had shorter postoperative stay (HoLEP: 1 [IQR 1-2] vs RASP: 2 [IQR 1-2], p = 0.04) and catheterization time (HoLEP: 2 [IQR 1.75-3] vs RASP: 5 [IQR 5-5], p < 0.001). A multivariable regression did not identify any factors predictive of trifecta outcomes. Conclusion: Given its comparable efficacy to RASP, HoLEP is the preferred treatment for BPH in large prostates because of its shorter hospital stay and catheterization time. Future randomized controlled trials are required to solidify indications for these treatment modalities and standardize treatment protocols for patients with medication-refractory BPH.

An Activity Network Design and Charging Facility Planning Model Considering the Influence of Uncertain Activities in a Game Framework

In the planning of public charging facilities and the charging activity network of users, there is a decision-making conflict among three stakeholders: the government, charging station enterprises, and electric vehicle users. Previous studies have described the tripartite game relationship in a relatively simplistic manner, and when designing charging facility planning schemes, they did not consider scenarios where users’ choice preferences undergo continuous random changes. In order to reduce the impacts of queuing phenomenon and resource idleness on the three participants, we introduce a bilateral matching algorithm combined with the dynamic Huff model as a strategy for EV charging selection in the passenger flow problem based on the three-dimensional activity network of time–space–energy of users. Meanwhile, the Dirichlet distribution is utilized to control the selection preferences on the user side, constructing uncertain scenarios for the choice of user charging activities. In this study, we establish a bilevel programming model that takes into account the uncertainty in social responsibility and user charging selection behavior. Solutions for the activity network and facility planning schemes can be derived based on the collaborative relationships among the three parties. The model employs a robust optimization method to collaboratively design the charging activity network and facility planning scheme. For this mixed-integer nonlinear multi-objective multi-constraint optimization problem, the model is solved by the NSGA-II algorithm, and the optimal compromise scheme is determined by using the EWM-TOPSIS comprehensive evaluation method for the Pareto solution set. Finally, the efficacy of the model and the solution algorithm is illustrated by a simulation example in a real urban space.

Paracetamol Use and COVID-19 Clinical Outcomes: A Meta-Analysis.

During the COVID-19 pandemic, paracetamol was widely recommended in different clinical settings, and sometimes advised over non-steroidal anti-inflammatory drugs (NSAIDs). These recommendations sparked a strong debate, with reports suggesting either potential benefits or harms for the individuals infected with SARS-CoV-2. As no systematic review is available, we performed a meta-analysis to estimate the impact of paracetamol on COVID-19 clinical outcomes compared to a placebo, no use, or NSAIDs. We searched PubMed, Scopus, Web of Science, and ClinicalTrials.gov for randomized trials or observational studies evaluating any COVID-19 clinical outcome. Data were combined using a generic inverse-variance approach. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach was used to determine the certainty of evidence for each outcome. One randomized trial and five observational studies, enrolling over 34,000 patients, were included. Overall, as compared to the patients using NSAIDs or receiving no treatment, the individuals who received paracetamol showed no significant differences in the risk of death (summary relative risks 0.93 and 0.91, respectively: both p > 0.05), need to transfer to the intensive care unit, need for respiratory support, or cardiovascular or renal complications. All studies showed a high risk of bias, with a low overall quality of evidence. This meta-analysis found no evidence of harmful or beneficial effects of paracetamol on main COVID-19-related outcomes. Also, the current literature does not provide sufficient data to support a preferential choice between paracetamol and NSAIDs for COVID-19 symptoms management. Further research is needed to confirm the present findings and provide critical insights on the policies to adopt in the case of future pandemics.

Choice versus no choice: Practical considerations for increasing choices.

Choice involves engaging in a selection response when multiple options are concurrently available. Choices can be incorporated into many components of behavior-analytic treatment such as providing clients with a choice between multiple items, activities, or tasks. We reviewed the main characteristics of 38 behavior-analytic articles that compared choice and no-choice conditions. We coded the experimental arrangements of choice and no-choice conditions and analyzed potential factors affecting preferences for choice and no choice. The findings suggest that the sizing of alternatives from which to choose, the timing of choice opportunities, and the timing of the delivery of the chosen option varied across the studies. Furthermore, preferences for choice shifted with differential reinforcement history and response effort manipulations of choice or no choice. The findings suggest that individual variables should be considered when providing choices, but more research is needed.

Household Migration and Adolescent Marriage Choice in Settings with Changing Marriage Systems

This article examines the relationship between family experiences of migration and adolescents’ preferences about who should make the decision about who to marry in two migrant-sending regions. Shifts in familial involvement in spouse choice, like other changes in marriage and family systems, are connected to broader social and economic changes that reduce the centrality of family relationships. Migrant household members may contribute to these changes by reorienting family relationships and interdependencies, or by exposing adolescents to new ideas and values. This study uses data collected in Gaza Province, Mozambique, and Chitwan Valley, Nepal as part of the Family Migration and Early Life Outcomes (FAMELO) project. Using logistic regression, the authors analyze variation in adolescents’ preferences for familial spouse choice by multiple aspects of migration (e.g., timing, receipt of remittances), controlling for adolescent characteristics and other theoretically relevant predictors. Mozambican adolescents in migrant-sending households were more likely to prefer families to choose their spouse than those in households without migration experience. In Nepal, household migration experience was not associated with adolescent spouse-selection preferences. The findings point to a complex association between migration systems and local family structures that shapes adolescents’ ideas about family relationships and their family-formation preferences.

Olfactory modulation of visual attention and preference towards congruent food products: An eye tracking study

In multisensory environments, odours often accompany visual stimuli, directing attention towards congruent objects. While previous research shows that people fixate longer on objects that match a recently smelled odour, it remains unclear whether odours directly influence product choices. Since odours persist in real-world settings, we investigated the effects of repeated odour exposure on visual attention and product choice, accounting for potential olfactory habituation. In a within-participant design, 30 participants completed a task where either a lemon odour (experimental condition) or clean air (control) was paired with congruent lemon-based food images, which varied to prevent visual habituation. We measured eye movements and choice preferences for these food products.Results revealed that participants exhibited longer gaze durations and more frequent fixations on food products congruent with the lemon odour. Repeated odour exposure had no effect on gaze patterns, as participants consistently focused on odour-congruent products throughout the experiment. The intensity and pleasantness of the lemon odour remained stable over time, suggesting no olfactory habituation occurred with this food-related odour. Despite this stable visual attention and odour intensity and pleasantness, participants began to diversify their product choices, selecting fewer odour-congruent items over time.These findings suggest that while odours continue to direct attention towards matching products, repeated exposure may reduce their influence on product choice, highlighting the complex role of olfactory stimuli in decision-making. The study provides insights into how odours interact with visual cues and influence consumer behaviour in prolonged exposure scenarios.

Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa.

Adolescence is a critical developmental period for the study of anorexia nervosa (AN), an illness characterized by extreme restriction of food intake. The maturation of the reward system during adolescence combined with recent neurobiological models of AN led to the hypothesis that early on in illness, restrictive food choices would be associated with activity in nucleus accumbens reward regions, rather than caudate regions identified among adults with AN. Healthy adolescents (HC, n = 41) and adolescents with AN or atypical AN (atypAN, n = 76) completed a Food Choice Task during fMRI scanning. Selection of high-fat foods and choice-related activation in nucleus accumbens and anterior caudate regions-of-interest (ROIs) were compared between individuals with AN/atypAN and HC. Associations were examined between choice-related activation and choice preferences among the AN group. Exploratory analyses examined associations between choice-related activation and psychological assessments among the patient group. Adolescents with AN or atypAN selected fewer high-fat foods than HC (t = -5.92, p < .001). Counter to predictions, there were no significant group differences in choice-related activation in the ROIs. Among individuals with AN or atypAN, choice-related neural activity in the anterior caudate was significantly negatively associated with high-fat food selections in the task (r = -.32, p = .024). In exploratory analyses, choice-related anterior caudate activation was positively associated with psychological measures of illness severity among patients (p's < .05, uncorrected). In this large cohort of adolescents with AN/atypAN, there was no evidence of altered reward system engagement during food choice. While there was no group difference in choice-related caudate activation, the associations with choices and psychological measures continue to suggest that this neural region is implicated in illness. Longitudinal analyses will clarify whether neural variability relates to longer-term course.

Evaluation of various commercial lipid removal sorbents for the detection of 18 neonicotinoid insecticides and their metabolites in meat by liquid chromatography tandem mass spectrometry

AbstractA highly accurate and precise method for the simultaneous detection of 18 neonicotinoids and their metabolites in meat was developed using liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). To improve the pretreatment step of the method, five different commercially available clean-up materials (including C18+PSA (primary secondary amine), Z-Sep (with Discover DSC-C18), EMR-Lipid, SHIMSEN QuEChERS, and Clean-up LPAS) were studied in the treatment of three meat matrices: pork, duck and yellow croaker. Based on the recovery data, we found that among the five purification materials, SHIMSEN QuEChERS was slightly more effective than the others for 18 neonicotinoids. Therefore, SHIMSEN QuEChERS was used as the purification sorbent, and the extraction solvents, extraction methods and chromatographic and mass spectrometric conditions were optimized. A matrix-matched calibration method was applied for quantification. In three different meat matrixes (pork, duck, and yellow croaker), all the target compounds showed good linearity, both with values of r2 &gt; 0.995. The average recovery of all neonicotinoids ranges from 63.4 to 114.2% (pork), 63.0–113.2% (duck), and 63.9–110.5% (yellow croaker). Relative standard deviations were all &lt;15% for intraday and interday precision. The values of limit of detection (LOD) and limit of quantification (LOQ) were, respectively, ranging from 0.04 to 1.0 μg kg−1 and 0.10 to 2.0 μg kg−1. Compared with previous reports, this method has advantage in LOQs, indicating that it it may be a preferred choice for the detection of neonicotinoid pesticides in meat samples.

Natural or organic? How framing impacts choices of sustainable food and wine products

PurposeThe paper investigates the choice preferences of Gen Z individuals between products labelled as “organic” versus products labelled as “natural”. While the former category guarantees production standards set by EU legislation, no codified standard exists for natural products. Understanding whether consumers value the difference is important for policy and marketing reasons.Design/methodology/approachThe paper uses a between-subject laboratory experiment. Participants are undergraduate students from a medium-sized university, randomized into two conditions. In both conditions, individuals choose between a conventional product and a sustainable one. In the first condition, we frame the organic product as “organic”. In the second condition, we frame the same organic product as “natural”. We always refer to the conventional product as “conventional”. This methodology is applied to a choice regarding wine and a choice regarding food. Choices are incentive-compatible, as one participant is randomly selected in each session to receive the chosen product.FindingsWe find no significant difference between the frequency of choices of the product framed as organic and the one framed as natural, neither for wine nor for food.Originality/valueThe paper tests in a controlled and incentivized laboratory experiment the choice differences regarding products framed as organic versus products framed as natural. The results provide policymakers and marketers with a better understanding of the effects of sustainability labelling on consumer behaviour. The policy implications of our results, which we discuss in the paper, are relevant and multifaceted.

A multi-stage game framework for new route promotion: Behavioral strategy and dynamic evolution of shippers, carriers, and governments

New freight routes are being planned and emerging globally, but often rely on government subsidies to enhance their competitiveness during the initial promotional phase. This study proposes a multi-stage game framework to explore the influence mechanism of behavioral strategies among three stakeholders: shipper, carrier, and government. Based on the assessment of shippers’ route choice preferences, we examine the dynamic evolution of carriers’ and governments’ behavioral strategies in the practical context of bounded rationality and dynamic learning. We theoretically derive the evolutionary paths and stable outcomes of dynamic systems across eight scenarios encompassing all the possible practical values to be taken, which provide broader and more valuable decision support for new route promotion. Finally, the feasibility and validity of the proposed model are verified by the actual case of the New International Land-Sea Trade Corridor. The findings indicate that government subsidies are not always effective and provide a precise subsidy range that can incentivize carriers to switch to the new route. Moreover, the study clarifies the impact of key factors such as subsidy, tax, route reliability, transportation time, and time value of cargo on the promotion of new routes through numerical simulation, and provides feasible management recommendations for government and route operations.

Urban-rural differences in preferences for traditional Chinese medicine services among chronic disease patients: a discrete choice experiment

BackgroundWith the increasing prevalence of chronic diseases, the demand for medical services from chronic disease patients has become diversified and personalized. The advantages and role of traditional Chinese medicine in the prevention and treatment of chronic diseases gradually emerging. The preferences and willingness to pay for traditional Chinese medicine services (TCMS) among patients with chronic diseases, as well as any disparities between urban and rural patients, have not been examined in past studies.ObjectiveThis study aimed to investigate the preferences of chronic disease patients for TCMS, explore the value/importance that patients place on different treatment attributes, and evaluate whether there are urban-rural differences in their preferences and willingness to pay for TCMS.MethodsA total of 317 patients from Jiangsu Province, China participated in a discrete choice experiment that elicited the preferences for TCMS. The choice questions were constructed by six attributes: out-of-pocket (OOP) cost, institution, medical provider, treatment method, treatment duration, treatment efficacy. Mixed logit models were used to estimate the stated preference and marginal willingness to pay for each attribute.ResultsThe choice preferences of chronic disease patients for TCMS in this study were influenced by the four attributes: institution, treatment method, and treatment efficacy, and OOP cost. Improvements in treatment efficacy were the most concerning, followed by being treated in traditional Chinese medicine (TCM) hospital. Patients were willing to pay more to get better treatment outcomes. Compared with primary care institutions, patients were willing to pay more for treatment in TCM hospitals. The preferences for economic attribute (OOP cost) varied between urban and rural areas, and rural patients tended to favor scenarios that imposed a lower economic burden on them.ConclusionThe chronic disease patients’ preferences for TCMS were determined mainly by treatment efficacy but also by institution, treatment method and OOP cost. The urban-rural difference in preference identified in this study highlights that effective policy interventions should consider the characteristics of patients’ demand in different regions.

Choice of alcohol over a natural reward: an experimental study in light and heavy social drinkers.

A core symptom of alcohol use disorder (AUD) is a progressively increased choice of alcohol over alternative rewards despite negative consequences. Here, we investigated choice between personalized alcohol vs. natural rewards in a laboratory setting, and compared this behavior between non-treatment-seeking heavy drinkers and light social drinkers. 30 light social drinkers (15 men drinking < 15 drinks/week and 15 women drinking < 10 drinks/week) and 30 heavy, non-treatment-seeking drinkers (drinking more than these levels; 15 women). In the Concurrent Choice Alcohol Food (CCAF) task, participants chose between individually tailored images of alcohol and snack rewards and collected points towards the respective reward. To assess cost sensitivity, points associated to the images varied so that they favored alcohol or snack, or were equal, creating three relative point levels. Choice preference for alcohol was strongly correlated with Alcohol Use Disorder Identification Test (AUDIT) scores, supporting the external validity of the choice procedure. Compared to light drinkers, heavy drinkers showed increased choice preference for alcohol, as indicated by a between-group difference in points of subjective equality, a metric that quantifies the relative point level at which alcohol and snacks were equally likely to be chosen. In both groups, choice preference strongly depended on the relative point level of alcohol compared to snacks, suggesting that responding for alcohol in heavy drinkers was sensitive to costs. Our results replicate previous findings of a relationship between self-reported alcohol use and choice preference for alcohol. We also found that choice behavior was strongly dependent on relative cost of alcohol in both groups, although price sensitivity was lower in heavy compared to light drinkers. An increased choice preference for alcohol in heavy drinkers suggests that they attribute a higher relative reinforcing value to alcohol compared to natural rewards.