Prednisolone For Rheumatoid Arthritis Research Articles

Surgical resection of a rapidly growing pulmonary spindle cell carcinoma by robot-assisted thoracoscopic surgery: a case report

BackgroundPulmonary spindle cell carcinoma (PSCC) is an extremely rare tumor that is highly malignant and fast-growing. As chemotherapy and radiation therapy are ineffective, early surgical resection is effective for PSCC.Case presentationA 70-year-old woman with rheumatoid arthritis was referred to our hospital with an abnormal shadow. Chest computed tomography revealed a 33-mm-wide lobular mass in the right upper lobe. She was diagnosed with non-small cell lung cancer by bronchoscopic smear cytology. Although staging evaluation indicated stage IIIB (T3N2M0) disease, she required continued administration of immunosuppressants and prednisolone for rheumatoid arthritis. Therefore, robot-assisted thoracoscopic surgery (RATS) right upper lobectomy followed by lymph node dissection was performed without preoperative chemotherapy and radiotherapy. Pathological findings revealed PSCC.ConclusionsWe report a very rare case of pulmonary spindle cell carcinoma, successfully resected with RATS.

Fournier's gangrene that initially mimicked pubic cellulitis in an elderly woman administered a Janus kinase inhibitor, methotrexate, and prednisolone for rheumatoid arthritis

This is the first reported case of FG during administration of a JAK inhibitor. The case appeared to be a less serious manifestation when first examined; however, extremely serious clinical features developed immediately after the withdrawal of TOF.

Bilateral Multiple Rib Fractures and Hump-Like Shadows on Chest Roentgenogram

A 58-year-old female with rheumatoid arthritis (RA), osteoarthritis of the bilateral knees, thoracic vertebral compression fractures, steroid-induced osteoporosis, and immune thrombocytopenia (ITP) presented with bilateral side chest pain. She had been treated with prednisolone for RA and ITP for 10 years. On her current visit, a chest roentgenogram revealed bilateral rib fractures and hump-like shadows. A chest computed tomography scan revealed multiple rib fractures accompanied by hematoma that pressed fractured ribs into the bilateral lungs. Regarding abnormal shadows on the chest roentgenogram, blood discharge from the fractured ribs formed the hematoma, causing the hump-like shadows

The right diagnosis but the wrong pathway? Listeria meningitis mimicking stroke

A 76-year-old woman presented to hospital by ambulance 45 min after developing sudden onset left face and arm weakness. She was taking methotrexate and prednisolone for rheumatoid arthritis. She had...

FRI0114 The effect of combination therapy and prednisolone on haemostatic markers in rheumatoid arthritis: The cobra-light study

BackgroundThere is accumulating evidence that rheumatoid arthritis (RA) should be considered as prothrombotic state, explaining the increased risk of thromboembolic events. Suppressing inflammation could reduce this hypercoagulability. COBRA, the combination...

Monocyte activation in rheumatoid arthritis (RA): increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids.

The aim of this work was to study the expression of beta 1- and beta 2-integrins, CR1, CD44 and Fc gamma receptors on peripheral blood monocytes in RA. The expression of these receptors was measured by flow cytometry, before and after treatment with low-dose prednisolone. Expression of the same receptors was also measured before and after treatment with metyrapone, a substance that inhibits the synthesis of cortisol in the adrenals. The expression of the beta 2-integrins CD11a, CD11b and CD18, of CD35 (CR1), and of Fc gamma RII and Fc gamma RI (CD32 and CD64) on monocytes was elevated in the RA patients compared with healthy controls, while the expression of the beta 1-integrins (CD29, CD49d, CD49f) was unaffected. A significant correlation between monocyte expression of CD64 and C-reactive protein (CRP), and blood platelet count, respectively, was found in the group of patients with RA. After 4-6 weeks of treatment with low-dose prednisolone, the expression on the monocytes of CD11a, CD11b, CD18, CD35, CD32 and CD64 was normalized. A significant correlation (r = 0.64, P = 0.02) was found between the decrease in expression of CD11b and clinical improvement after prednisolone treatment. Two days of metyrapone treatment, which significantly lowered the serum cortisol levels, elevated the expression of CD35 and CD49f. Priming of peripheral monocytes seems to be one of the mechanisms behind the recruitment of monocytes to the rheumatoid synovium. One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.

Prednisone and Prednisolone in Rheumatoid Arthritis: An Evaluation of Their Therapeutic Efficiency

Prednisone and Prednisolone in Rheumatoid Arthritis: An Evaluation of Their Therapeutic Efficiency