The stress generation model posits that not only stressful life-events predict depressive symptoms, but also depressive-prone individuals think and behave in ways that make them more vulnerable to experience life-stress. Evidence has supported the bi-directional relationship between stress and depressive symptoms, and there has been an attempt in identifying vulnerability factors for stress generation. Yet, there is a need for studies focusing on multiple risk factors and a replication of findings in non-Western samples. The aim of the present study was to examine the role of rumination and excessive reassurance seeking (ERS) in stress generation in a sample of Turkish young adults. A sample of 318 Turkish college students reported on their rumination, ERS, intensity of stressful life-events and depressive symptoms. A subsample of 162 participants also completed a measure of life-events 5 months later. Cross-sectional results showed that rumination and ERS contribute to life-stress over and above depressive symptoms and gender. Mediational analyses indicated that ERS does not mediate the relationship between rumination and life-stress at 5 months. Rather, rumination fully mediated the relationship between ERS and future life-stress. Results provide evidence for stress generation, and highlight the interconnection between rumination and ERS.