Glucose Prediction Research Articles

The Impact of Clinical Parameters on LSTM-based Blood Glucose Estimate in Type 1 Diabetes

Accurate forecasting of blood sugar levels is essential for managing diabetes, especially Type-1 reducing incidences, and diminishing care, costs in patients. In this study, a Long Short-Term Memory Recurrent Neural Network (LSTM) model has been employed to predict blood glucose levels using clinical data. The research focuses on identifying and analyzing several key parameters that play a significant role in determining future blood glucose levels, ensuring a robust and reliable prediction framework. We have considered patient-specific features: Insulin-Sensitivity-Factor (ISF), total daily dose (TDD) of insulin, HbA1C levels, height and weight of a patient, and age and gender while analyzing the prediction performance for Blood Glucose. We thought training LSTM models on a large dataset and studying the most important predictors with their predictive power would be beneficial. The results indicate that including these clinical parameters improves the accuracy of blood glucose prediction and provides valuable information for individuals to control diabetes. This analysis highlights the efficiency of LSTM networks in making use of patient data to improve prediction models, eventually aiding more effective and individualized treatment strategies for Type 1 diabetic patients (T1D). This work also examines the extent to which each parameter influences the prediction of future blood glucose levels, providing deeper insights into their relative impact and significance in the predictive model.

A multi-band spectral data fusion method for improving the accuracy of quantitative spectral analysis

The signal-to-noise ratio of the spectrum is a critical determinant of detection accuracy in compositional analysis utilizing spectroscopy. The spectral data acquired by the spectrometer, while intended to capture essential sample characteristics, is often interspersed with various noise interferences. This contamination can severely disrupt the integrity of measurement outcomes. Therefore, this paper proposes the "multi-band spectral data fusion" method. In order to verify the feasibility of this method, this paper takes blood detection based on dynamic spectroscopy as an example and develops two models for each of the various components in blood. The experimental results show that when compared to modeling the raw spectrum data of the samples directly, the prediction accuracy of the model constructed using the new spectra processed by the multi-band spectral data fusion method suggested in this paper is greater. The correlation coefficient of the hemoglobin prediction set has improved by 13.48 %, and the root mean square error has decreased by 21.00 %. The correlation coefficient of the blood glucose prediction set improved by 4.07 %, and the root mean square error decreased by 12.78 %. The result demonstrates that the proposed method effectively mitigates the impact of random errors without compromising the spectral information content. The approach is not limited to blood component analysis but has potential applications across diverse spectroscopic domains, providing new ideas and methods for improving the accuracy of quantitative spectroscopic analysis.

LGformer: Informer-based personalized modeling for blood glucose prediction

LGformer: Informer-based personalized modeling for blood glucose prediction

A new multivariate blood glucose prediction method with hybrid feature clustering and online transfer learning.

Accurate blood glucose (BG) prediction is greatly benefit for the treatment of diabetes. Generally, clinical physicians are required to comprehensively analyze various factors, such as patient's body temperature, meal, sleep, insulin injection, continuous glucose monitoring (CGM), and other information, to evaluate the fluctuation trend of blood glucose. To address this problem, this paper proposes a multivariate blood glucose prediction method based on mixed feature clustering. It clusters time series data with diverse or mixed features related to blood glucose, effectively leveraging correlations and distribution characteristics. By combining incremental clustering of multivariate time series with transfer learning, this method achieves online prediction of blood glucose levels. The experimental results indicate that the proposed method can decrease the prediction error RMSE by 4.2% (PH=30min) and 5.9% (PH=60min). Compared with other prediction methods, the training time of the multivariate prediction method is reduced by 5.2% (PH=30min) and 4.7% (PH=60min). It was also validated and compared with other methods in a real dataset. The proposed method in this study has lower prediction error and better prediction performance in the prediction horizon(PH) of PH=30, 45, 60, 75, and 90min, respectively. Compared with the traditional unitary and multivariate time series prediction method, the approach proposed in this paper significantly improves the accuracy and robustness of blood glucose prediction. According to the evaluation results on the data set from OhioT1DM and the Sixth People's Hospital of Shanghai, the proposed method has better generalization performance and clinical acceptability.

Convolutional neural network for colorimetric glucose detection using a smartphone and novel multilayer polyvinyl film microfluidic device

Detecting glucose levels is crucial for diabetes patients as it enables timely and effective management, preventing complications and promoting overall health. In this endeavor, we have designed a novel, affordable point-of-care diagnostic device utilizing microfluidic principles, a smartphone camera, and established laboratory colorimetric methods for accurate glucose estimation. Our proposed microfluidic device comprises layers of adhesive poly-vinyl films stacked on a poly methyl methacrylate (PMMA) base sheet, with micro-channel contours precision-cut using a cutting printer. Employing the gold standard glucose-oxidase/peroxidase reaction on this microfluidic platform, we achieve enzymatic glucose determination. The resulting colored complex, formed by phenol and 4-aminoantipyrine in the presence of hydrogen peroxide generated during glucose oxidation, is captured at various glucose concentrations using a smartphone camera. Raw images are processed and utilized as input data for a 2-D convolutional neural network (CNN) deep learning classifier, demonstrating an impressive 95% overall accuracy against new images. The glucose predictions done by CNN are compared with ISO 15197:2013/2015 gold standard norms. Furthermore, the classifier exhibits outstanding precision, recall, and F1 score of 94%, 93%, and 93%, respectively, as validated through our study, showcasing its exceptional predictive capability. Next, a user-friendly smartphone application named “GLUCOLENS AI” was developed to capture images, perform image processing, and communicate with cloud server containing the CNN classifier. The developed CNN model can be successfully used as a pre-trained model for future glucose concentration predictions.

Predicting Dysglycemia in Patients with Diabetes Using Electrocardiogram.

Background: In this study, we explored the potential of predicting dysglycemia in patients who need to continuously manage blood glucose levels using a non-invasive method via electrocardiography (ECG). Methods: The data were collected from patients with diabetes, and heart rate variability (HRV) features were extracted via ECG processing. A residual block-based one-dimensional convolution neural network model was used to predict dysglycemia. Results: The dysglycemia prediction results at each time point, including at the time of blood glucose measurement, 15 min prior to measurement, and 30 min prior to measurement, exhibited no significant differences compared with the blood glucose measurement values. This result confirmed that the proposed artificial intelligence model for dysglycemia prediction performed well at each time point. Additionally, to determine the optimal number of features required for predicting dysglycemia, 77 HRV features were individually eliminated in the order of decreasing importance with respect to the prediction accuracy; the optimal number of features for the model to predict dysglycemia was determined to be 12. The dysglycemia prediction results obtained 30 min prior to measurement, which exhibited the highest prediction range in this study, were as follows: accuracy = 90.5, sensitivity = 87.52, specificity = 92.74, and precision = 89.86. Conclusions: Furthermore, we determined that no significant differences exist in the blood glucose prediction results reported in previous studies, wherein various vital signs and blood glucose values were used as model inputs, and the results obtained in this study, wherein only ECG data were used to predict dysglycemia.

Risk Prediction of high blood glucose among women (15–49 years) and men (15–54 years) in India: An analysis from National Family Health Survey-5 (2019–21)

ABSTRACT Context: Approximately 500 million individuals worldwide are known to have diabetes, representing roughly 1 out of every 11 adults in the world. Approximately 45.8% of adult diabetes cases are believed to be undiagnosed. Aim: This study aimed to identify the predictors for high blood glucose and to develop a risk score which helps in early detection of high blood glucose among Indian men (15–54 years) and women (15–49 years). Methods and Material: This study utilised data from the National Family Health Survey-5, which were gathered between 2019 and 2021. The study population comprises women aged 15–49 years and men aged 15–54 years in India. Statistical Analysis Used: A logistic regression analysis was conducted to determine the predictors of high blood glucose. The results were expressed as odds ratios with 95% confidence intervals. The risk score for high blood glucose was derived through variable shrinking and by employing regression coefficients obtained from the standard logistic regression model. Data were analysed using IBM SPSS version 26. Results: The prevalence of high blood glucose in India was 9.3%. The study findings indicated an association between age and the occurrence of high blood glucose levels. The prevalence of high blood glucose was higher among males (11.1% vs 7.5%), individuals living in urban areas (10.7% vs 8.9%), those with a waist circumference exceeding the specified limit (11.7% vs 5.9%), and individuals who were overweight or obese (11.3%). The prevalence of high blood glucose was higher among alcoholics (13.2% vs 8.8%) and various forms of tobacco users (12.1% vs 8.4%). Conclusions: Age, sex, place of residence (urban), consumption of alcohol, hypertension, and waist circumference were found to be the significant predictor variables and were used to develop the risk prediction score using the logistic regression model.

Machine Learning Algorithms Based on Time Series Pre-Clustering for Nocturnal Glucose Prediction in People with Type 1 Diabetes.

Background: Machine learning offers new options for glucose prediction and real-time glucose management. The aim of this study was to develop a machine learning-based algorithm that takes into account glucose dynamics patterns for predicting nocturnal glucose in individuals with type 1 diabetes. Methods: To identify glucose patterns, we applied a hierarchical clustering algorithm to real-time continuous glucose monitoring data obtained from 570 adult patients. Machine learning algorithms with or without pre-clustering were used for modeling. Results: Eight clusters without nocturnal hypoglycemia and six clusters with at least one low-glucose episode were identified by the cluster analysis. When forecasting time series without hypoglycemia with a prediction horizon (PH) of 15 or 30 min, gradient boosting trees (GBTs) with pre-clustering and random forest (RF) with pre-clustering outperformed algorithms based on medoids of time series clusters, the Holt model, and GBTs without pre-clustering. When forecasting time series with low-glucose episodes, a model based on the pre-clustering and GBTs provided the highest predictive accuracy at PH = 15 min, and a model based on RF with pre-clustering was the best at PH = 30 min. Conclusions: The results indicate that the clustering of glucose dynamics can enhance the efficacy of machine learning algorithms used for glucose prediction.

Significant of Blood Glucose Time-Series Forecasting with Temporal Fusion Transformer Model for Type 1 Diabetes

Blood glucose (BG) prediction has advanced to a state of the art thanks to deep learning models, which have been demonstrated to enhance type 1 diabetes (T1D) therapy. Nevertheless, most current models are limited to single-horizon prediction and have several practical drawbacks, including poor interpretability. In this study, we develop a novel approach to optimize the forecasting model in the training processes using the Optuna function, cross-validation, and the latest dataset. We offer a novel deep learning framework for multi-horizon BG prediction: the temporal fusion transformer (TFT). TFT employs a self-attention mechanism to extract long-term temporal dependencies and enables a model with an auto-tuning adjustment approach on hyperparameters and a cross-validation function on univariate and multivariate input models. On a clinical dataset with T1D subjects, namely ShanghaiT1DM (16 subjects), D1NAMO (9 subjects), and OhioT1DM (6 subjects) datasets, it achieved an average root mean square error (RMSE) of the three datasets used. The TFT model gave a lower error score than the baseline models of neural hierarchical interpolation for time series (N-HiTS)and long short-term memory (LSTM) with the values of 10.08+0.31 mg/dL and 12.34+0.62 mg/dL on the univariate input model and 9.18+1.21 mg/dL and 14.33+0.52 mg/dL on the multivariate input model for the prediction horizons of 30 and 60 minutes, respectively. This result explained that the TFT model was adequate for carrying out multi-horizon BG value-level forecasting and potentially deploying on-edge devices to improve clinical efforts to manage BG levels for T1D patients in real-time application.

Enhanced Diabetes Detection and Blood Glucose Prediction Using TinyML-Integrated E-Nose and Breath Analysis: A Novel Approach Combining Synthetic and Real-World Data.

Diabetes mellitus, a chronic condition affecting millions worldwide, necessitates continuous monitoring of blood glucose level (BGL). The increasing prevalence of diabetes has driven the development of non-invasive methods, such as electronic noses (e-noses), for analyzing exhaled breath and detecting biomarkers in volatile organic compounds (VOCs). Effective machine learning models require extensive patient data to ensure accurate BGL predictions, but previous studies have been limited by small sample sizes. This study addresses this limitation by employing conditional generative adversarial networks (CTGAN) to generate synthetic data from real-world tests involving 29 healthy and 29 diabetic participants, resulting in over 14,000 new synthetic samples. These data were used to validate machine learning models for diabetes detection and BGL prediction, integrated into a Tiny Machine Learning (TinyML) e-nose system for real-time analysis. The proposed models achieved an 86% accuracy in BGL identification using LightGBM (Light Gradient Boosting Machine) and a 94.14% accuracy in diabetes detection using Random Forest. These results demonstrate the efficacy of enhancing machine learning models with both real and synthetic data, particularly in non-invasive systems integrating e-noses with TinyML. This study signifies a major advancement in non-invasive diabetes monitoring, underscoring the transformative potential of TinyML-powered e-nose systems in healthcare applications.

Comparison of feature learning methods for non-invasive interstitial glucose prediction using wearable sensors in healthy cohorts: a pilot study

BackgroundAlterations in glucose metabolism, especially the postprandial glucose response (PPGR), are crucial contributors to metabolic dysfunction, which underlies the pathogenesis of metabolic syndrome (MetSyn). Personalized low-glycemic diets (PLGD) have shown promise in reducing postprandial glucose spikes. However, current methods such as invasive continuous glucose monitoring (CGM) or multi-omics data integration to assess PPGR come with limitations, including cost and invasiveness, hindering widespread adoption in primary disease prevention. Our aim is to assess machine-learning algorithms for predicting individual PPGR using non-invasive wearable data, thereby circumventing the limitations associated with existing approaches. By identifying the most accurate model, we seek to provide a more accessible and efficient method for managing glucose metabolism. MethodsThis data-driven analysis utilized the experimental dataset from the SENSE (”Systemische Ernährungsmedizin”) study. Healthy participants used an Empatica E4 wristband and Abbott Freestyle Libre 3 CGM for ten days. Blood volume pulse (BVP), electrodermal activity (EDA), heart rate (HR), skin temperature (TEMP), and the corresponding CGM values were measured. Subsequently, four data-driven deep learning (DL) model-convolutional neural network (CNN), lightweight transformer (LTF), long short-term memory with attention (LSTM-A), and Bi-directional LSTM (BiLSTM)-were implemented and compared to determine the potential of DL in predicting interstitial glucose levels without involving food and activity logs. ResultsThe proposed BiLSTM achieved the best interstitial glucose prediction performance, with an average root mean squared error (RMSE) of 13.42 mg/dL, an average mean absolute percentage error (MAPE) of 0.12, and only 3.01% values falling within area D in Clarke error grid analysis (CEGA), incorporating the leave-one-out cross-validation (LOOCV) strategy for a five-minute prediction horizon. ConclusionThe findings of this study may demonstrate the feasibility of transferring knowledge gained from invasive glucose monitoring devices to non-invasive approaches. Furthermore, it emphasizes the promising prospects of combining deep learning with wearable technologies to predict glucose levels in healthy individuals.

Blood glucose prediction using non-invasive optical system based on photoplethysmography

Blood glucose prediction using non-invasive optical system based on photoplethysmography

Forecasting glucose values for patients with type 1 diabetes using heart rate data

Background:Type 1 Diabetes Mellitus (T1DM) is a chronic metabolic disease affecting millions of people worldwide. T1DM requires patients to continuously monitor their blood glucose levels. Due to pancreatic dysfunctions, patients use insulin injections to correct glucose values by synthetic insulin. Continuous Glucose Monitoring (CGM) is a system which includes an algorithm allowing to measure (and in some cases to predict) glucose levels at a frequent sampling time. This enable implementing advanced devices, including automated insulin pump delivery. Nevertheless, CGM still presents some limitations, including (i) the delay (time lag) in detecting change in glucose levels compared to the traditional blood glucose measurement, and (ii) the lack of a sufficient and acceptable time to accurately predict glucose values. Methods:We propose a framework based on a Gated Recurrent Unit (GRU) model to forecast both short- and long-term glucose values using heart rate (HR) and interstitial glucose (IG) values. The framework acquires HR and IG data and predicts glucose values with higher precision compared to state-of-the-art models. For training and testing the proposed framework, we used the OhioT1DM Dataset, which includes physiological data such as HR and IG values collected over an 8-week observation period. Additionally, we validated our framework using two other glucose datasets to ensure its generalizability across different HR and IG sampling frequencies. The proposed framework can be used to optimize the CGM system by incorporating patient HR measurements, thereby improving the prediction of short- and long-term glucose levels and reducing risks associated with conditions like hypoglycemia. Results:Experimental tests were conducted using HR and IG data from the OhioT1DM Dataset, as well as from two additional T1DM patient datasets. We analyzed 6 patients from Ohio dataset while we validated the algorithm on 23 patients coming from two different university hospitals (6 from the University of Catanzaro medical hospital and 17 gathered from a validated study at IRCCS San Matteo Hospital in Pavia) for a total number of 29 patients. Our framework demonstrates an improvement in forecasting IG values in terms of RMSE and MAE for different choice of prediction horizons (PH). In the case of a PH of 5, 10, 20, 30, and 60 min, we reach an RMSE of 5.0, 9.38, 15.27, 20.48, and 34.16 respectively. The framework is freely available as an open-source, with an example dataset on a GitHub repository (see https://github.com/rafgia/attention_to_glycemia). Conclusion:Our framework offers a promising solution for improving glucose level prediction and management in T1DM patients. By leveraging a GRU model and incorporating HR and IG values, we achieve more precise glucose level forecasting compared to state-of-the-art models. This approach not only enhances the accuracy of glucose predictions but also mitigates the risks associated with hypoglycemia.

Continuous glucose monitoring using machine learning models and IoT device data: A meta-analysis.

Machine learning offers diverse options for effectively managing blood glucose levels in diabetes patients. Selecting the right ML algorithm is critical given the array of available choices. Integrating data from IoT devices presents promising opportunities to enhance real-time blood glucose management models. This meta-analysis aims to evaluate the effectiveness of machine learning models utilizing IoT device data for predicting blood glucose levels. We systematically searched electronic databases for studies published between 2019 and 2023. We excluded studies lacking ML model derivation or performance metrics. The Quality Assessment of Diagnostic Accuracy Studies tool assessed study quality. Our primary outcomes compared ML models for BG level prediction across different prediction horizons (PHs). We analyzed ten eligible studies across prediction horizons of 15, 30, 45, and 60 minutes. ML models exhibited mean absolute RMSE values of 15.02 (SD 1.45), 21.488 (SD 2.92), 30.094 (SD 3.245), and 35.89 (SD 6.4) mg/dL, respectively. Random Forest demonstrated superior performance across these PHs. We observed significant heterogeneity across all subgroups, indicating diverse sources of variability. As the PH lengthened, the RMSE for blood glucose prediction by the ML model increased, with Random Forest showing the highest relative performance among the ML models.

BGformer: An improved Informer model to enhance blood glucose prediction

Accurately predicting blood glucose levels is crucial in diabetes management to mitigate patients’ risk of complications. However, blood glucose values exhibit instability, and existing prediction methods often struggle to capture their volatile nature, leading to inaccurate trend forecasts. To address these challenges, we propose a novel blood glucose level prediction model based on the Informer architecture: BGformer. Our model introduces a feature enhancement module and a microscale overlapping concerns mechanism. The feature enhancement module integrates periodic and trend feature extractors, enhancing the model’s ability to capture relevant information from the data. By extending the feature extraction capacity of time series data, it provides richer feature representations for analysis. Meanwhile, the microscale overlapping concerns mechanism adopts a window-based strategy, computing attention scores only within specific windows. This approach reduces computational complexity while enhancing the model’s capacity to capture local temporal dependencies. Furthermore, we introduce a dual attention enhancement module to augment the model’s expressive capability. Through prediction experiments on blood glucose values from sixteen diabetic patients, our model outperformed eight benchmark models in terms of both MAE and RMSE metrics for future 60-minute and 90-minute predictions. Our proposed scheme significantly improves the model’s dependency-capturing ability, resulting in more accurate blood glucose level predictions.

A novel neural network architecture utilizing parametric-logarithmic-modulus-based activation function: Theory, algorithm, and applications

This paper introduces a novel parametric-logarithmic-modulus-based activation function (PLM-AF) designed to significantly enhance the nonlinear expression capabilities of high-dimensional spectroscopy data. A one-dimensional CNN-LSTM (1D-CNN-BiLSTM) model is subsequently developed to capture long-term dependencies within glucose Raman spectroscopy. To the best of our knowledge, this is the first work to simultaneously optimize the predictive performance of the model from the perspectives of both network architecture and activation functions. The effectiveness of the model is comprehensively evaluated against state-of-the-art methods using a public Raman spectroscopy dataset. Compared to the sub-optimal glucose prediction models, the proposed model improves the training root mean square error (RMSE) by 41.89%. The improved prediction accuracy demonstrates that the proposed regression model with the novel PLM-AF can significantly facilitate non-invasive glucose concentration prediction, thereby advancing the auxiliary diagnosis and healthcare industry.

Fear of Hypoglycemia and Diabetes Distress: Expected Reduction by Glucose Prediction.

Extended glucose predictions are novel in diabetes management. Currently, there is no solution widely available. People with diabetes mellitus (DM) are offered features like trend arrows and limited predictions linked to predefined situations. Thus, the impact of extended glucose predictions on the burden of diabetes and person-reported outcomes (PROs) is unclear. In this online survey, 206 people with type 1 and type 2 diabetes (T1D and T2D), 70.9% and 29.1%, respectively, who participated in the dia·link online panel and were current continuous glucose monitoring (CGM) users, were presented with different scenarios of hypothetical extended glucose predictions. They were asked to imagine how low glucose predictions of 30 minutes and overnight as well as glucose predictions up to 2 hours would influence their diabetes management. Subsequently, they completed the Hypoglycemia Fear Survey II (HFS-II) and the T1 Diabetes Distress Scale (T1-DDS) by rating each item on a 5-point scale (-2: strong deterioration to +2: strong improvement) according to the potential change due to using glucose predictions. For all glucose prediction periods, 30 minutes, up to 2 hours, and at nighttime, the surveyed participants expected moderate improvements in both fear of hypoglycemia (HFS-II: 0.57 ± 0.49) and overall diabetes distress (T1-DDS = 0.44 ± 0.49). The T1-DDS did not differ for type of therapy or diabetes. People with T1D and T2D would see glucose predictions as a potential improvement regarding reduced fear of hypoglycemia and diabetes distress. Therefore, glucose predictions represent a value for them in lowering the burden of diabetes and its management.

Enhancing the Capabilities of Continuous Glucose Monitoring With a Predictive App.

Despite abundant evidence demonstrating the benefits of continuous glucose monitoring (CGM) in diabetes management, a significant proportion of people using this technology still struggle to achieve glycemic targets. To address this challenge, we propose the Accu-Chek® SmartGuide Predict app, an innovative CGM digital companion that incorporates a suite of advanced glucose predictive functionalities aiming to inform users earlier about acute glycemic situations. The app's functionalities, powered by three machine learning models, include a two-hour glucose forecast, a 30-minute low glucose detection, and a nighttime low glucose prediction for bedtime interventions. Evaluation of the models' performance included three data sets, comprising subjects with T1D on MDI (n = 21), subjects with type 2 diabetes (T2D) on MDI (n = 59), and subjects with T1D on insulin pump therapy (n = 226). On an aggregated data set, the two-hour glucose prediction model, at a forecasting horizon of 30, 45, 60, and 120 minutes, achieved a percentage of data points in zones A and B of Consensus Error Grid of: 99.8%, 99.3%, 98.7%, and 96.3%, respectively. The 30-minute low glucose prediction model achieved an accuracy, sensitivity, specificity, mean lead time, and area under the receiver operating characteristic curve (ROC AUC) of: 98.9%, 95.2%, 98.9%, 16.2 minutes, and 0.958, respectively. The nighttime low glucose prediction model achieved an accuracy, sensitivity, specificity, and ROC AUC of: 86.5%, 55.3%, 91.6%, and 0.859, respectively. The consistency of the performance of the three predictive models when evaluated on different cohorts of subjects with T1D and T2D on different insulin therapies, including real-world data, offers reassurance for real-world efficacy.

Concept and Implementation of a Novel Continuous Glucose Monitoring Solution With Glucose Predictions on Board.

The recently CE-marked continuous real-time glucose monitoring (rtCGM) solution Accu-Chek® (AC) SmartGuide Solution was developed to enable people with diabetes mellitus (DM) to proactively control their glucose levels using predictive technologies. The comprehensive solution consists of three components that harmonize well with each other. The CGM device is composed of a sensor applicator and a glucose sensor patch whose data are transferred to the connected smartphone by Bluetooth® Low Energy. The user interface of the CGM solution is powered by the AC SmartGuide app delivering current and past glucose metrics, and the AC SmartGuide Predict app providing a glucose prediction suite enabled by artificial intelligence (AI). This article describes the innovative CGM solution.

Clinical Usage and Potential Benefits of a Continuous Glucose Monitoring Predict App.

Continuous glucose monitoring (CGM) has become an increasingly important tool for self-management in people with diabetes mellitus (DM). In this paper, we discuss recommendations on how to implement predictive features provided by the Accu-Chek SmartGuide Predict app in clinical practice. The Predict app's features are aimed at ultimately reducing diabetes stress and fear of hypoglycemia in people with DM. Furthermore, we explore the use cases and potential benefits of continuous glucose prediction, predictions of low glucose, and nocturnal hypoglycemia.