An efficient heat transfer phenomenon using nanofluid have greater challenges in various industries, engineering application the recent trend. Keeping this in present scenario, this study aims to optimize the heat transmission rate in the magnetized flow of nanomaterials through a rotating, spinning sphere. The heat transfer phenomena in the time-dependent fluid are enhanced by the incorporation of nonlinear radiation and a variable heat source. Additionally, the free convective flow is influenced by the effects of thermal buoyancy and a transverse magnetic field. The proposed model along with several factors is standardized through adequate transformation rules. Further, shooting-based Runge-Kutta technique is adopted with the help of built-in MATLAB function bvp4c for the solution of the transformed system. The prime focus of the proposed work is the optimizing heat transfer rate combined with regression analysis using artificial neural network and then it uses Levenberg Marquardt algorithm with well-posed training, testing, and validation data. The error analysis also presented briefly and the variation of characterizing parameters is depicted via graphs. Further, the important outcomes are; the particle concentration of carbon nanotubes contributes to decelerating the velocity profiles, leading to an increase in boundary layer thickness. In contrast, increasing magnetization has the opposite effect. Both nonlinear radiative heat and an additional heat source enhance the heat transfer phenomenon.