In the materials science domain, the accurate prediction of the yield strength of metallic compositions has often resulted in extensive experimental endeavors, leading to inefficiencies in both time and resources. Here, we introduce an innovative approach to predict yield strength, which can be applied to a variety of metallic substances ranging from the simplest pure metals to the most intricate alloys under varying temperatures and strain rates. The fusion of grain boundary sliding mechanism and cutting-edge machine-learning algorithm forges an expansive framework, which can help realize the critical factors influencing yield strength. The validity and wide applicability of the proposed framework were rigorously confirmed through experimental evaluations conducted on selected Fe-based alloys, such as Fe60Ni25Cr15, Fe60Ni30Cr10, and Fe64Ni15Co8Mn8Cu5. This breakthrough study significantly streamlines experimental design processes, optimizes resource utilization, and marks a significant leap forward in creating a reliable predictive framework for realizing material properties.