The motivation for using artificial neural networks in this study stems from their computational efficiency and ability to model complex, high-level abstractions. Deep learning models were utilized to predict the structural responses of reinforced concrete (RC) buildings subjected to earthquakes. For this aim, the dataset for training and evaluation was derived from complex computational dynamic analyses, which involved scaling real ground motion records at different intensity levels (spectral acceleration Sa(T1) and the recently proposed INp). The results, specifically the maximum interstory drifts, were characterized for the output neurons in terms of their corresponding statistical parameters: mean, median, and standard deviation; while two input variables (fundamental period and earthquake intensity) were used in the neural networks to represent buildings and seismic risk. To validate deep learning as a robust tool for seismic predesign and rapid estimation, a prediction model was developed to assess the seismic performance of a complex RC building with buckling restrained braces (RC-BRBs). Additionally, other deep learning models were explored to predict ductility and hysteretic energy in nonlinear single degree of freedom (SDOF) systems. The findings demonstrated that increasing the number of hidden layers generally reduces prediction error, although an excessive number can lead to overfitting.