This paper presents a comprehensive study of the dynamic response analysis of vehicle–bridge coupled systems, with detailed simulation methods for the vehicles, bridges, and wheel–road coupling relationships. The simulation of the entire vehicle–bridge coupling system is carried out using the open-source finite element analysis platform OpenSees. A novel three-dimensional wheel–road coupling element is introduced to model the interactions between the wheel and road nodes. This element facilitates precise computation of the dynamic responses within the vehicle–bridge coupled system, including both vehicle and bridge behaviors, along with the interaction forces between the wheels and the bridge surface. The coupling element consists of a wheel node and all potential road nodes on the bridge surface that the wheel may traverse. This configuration preserves the finite element model of the entire vehicle–bridge coupled system throughout the vehicle’s movement, thereby improving the efficiency of numerical simulations of vehicle–road interactions. The study accounts for the impact of random road irregularities on the dynamic responses of both the vehicle and the bridge. These irregularities are treated as input parameters for the wheel–road coupling element rather than being accounted for through the wheel–road interaction constraint equations, thereby improving the convenience of simulating random road irregularities.