Objectives This study examined the effects of the exchange relationship with a preceptor on self-efficacy, resilience, and job satisfaction among new nurses. Methods Data were collected from 125 new nurses in a hospital in City S by questionnaire after 8 weeks of preceptor-ship. Data were analyzed using t-test, one-way analysis of variance, Pearson correlation coefficient analysis, and linear regression analysis. Results The exchange relationship between new nurses and preceptors was statistically significantly correlated with self-efficacy(p=.024), resilience(p=.003), and job satisfaction(p<.001). The higher the relationship between new nurses and preceptors, the higher the self-efficacy (B=0.281, p=.024), resilience (B=0.304, p=.003), and job satisfaction (B=0.507, p<.001). Conclusions The results of this study showed that the higher the relationship between new nurses and their preceptors, the higher their self-efficacy, resilience, and job satisfaction. Therefore, it is necessary to provide education and self-development for preceptors so that they can play the role of role model, emotional support, and counselor as well as educator to new nurses.