Precatalysts For Reactions Research Articles

New organometallic Schiff-base copper complexes as efficient “click” reaction precatalysts

In the presence of sodium ascorbate, recyclable CuAAC precatalysts displayed high activity allowing the synthesis of a wide variety of 1,4-disubstituted 1,2,3-triazoles in high isolated yields.

Simple, efficient protocols for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine

Simple and efficient procedures for the Pd-catalyzed cross-coupling reaction of aryl chlorides and dimethylamine are described. At room temperature with a strong base, t-BuXPhos is employed as the supporting ligand; at 110 °C with a weak base, XPhos is employed as the supporting ligand. In each of these cases, commercially available solutions constitute the source of the dimethylamine, and recently disclosed precatalysts constitute the source of the ligand and Pd. This work further expands the utility of these precatalysts in reactions that benefit from an easily activated source of L 1Pd(0).