In this study, power spectral analysis and bandpass filtering of daily meteorological fields are performed to explore the roles of synoptic to quasi-monthly disturbances in influencing the generation of pre-summer heavy rainfall over South China. Two heavy rainfall episodes are selected during the months of April−June 2008−15, which represent the collaboration between the synoptic and quasi-biweekly disturbances and the synoptic and quasi-monthly disturbances, respectively. Results show that the first heavy rainfall episode takes place in a southwesterly anomalous flow associated with an anticyclonic anomaly over the South China Sea (SCS) at the quasi-biweekly scale with 15.1% variance contributions, and at the synoptic scale in a convergence zone between southwesterly and northeasterly anomalous flows associated with a southeastward-moving anticyclonic anomaly on the leeside of the Yungui Plateau and an eastward-propagating anticyclonic anomaly from higher latitudes with 35.2% variance contribution. In contrast, the second heavy rainfall episode takes place in southwest-to-westerly anomalies converging with northwest-to-westerly anomalies at the quasi-monthly scale with 23.2% variance contributions to the total rainfall variance, which are associated with an anticyclonic anomaly over the SCS and an eastward-propagating cyclonic anomaly over North China, respectively. At the synoptic scale, it occurs in south-to-southwesterly anomalies converging with a cyclonic anomaly on the downstream of the Yungui Plateau with 49.3% variance contributions. In both cases, the lower-tropospheric mean south-to-southwesterly flows provide ample moisture supply and potentially unstable conditions; it is the above synoptic, quasi-biweekly or quasi-monthly disturbances that determine the general period and distribution of persistent heavy rainfall over South China.