Abstract. The purpose of the work is to study the effect of the biological preparation “Bigus, VR” on potato crops, in order to increase the yield and quality of the resulting products in the foothill zone of the Republic of North Ossetia – Alania. Methods. Field trials in during 2020–2022 were carried out at the experimental plot of the North Caucasus Scientific Research Institute of Mountain and Foothill Agriculture – a branch of the Federal Center “Vladikavkaz Scientific Center of the Russian Academy of Sciences”, the soil of which is leached medium-power chernozem, according to generally accepted methods. Results. It has been found out that biopreparation “Bigus, VR” promotes the increase of biometric parameters of potatoes of varieties Farn, Nevskiy and Barna on all experimental variants in comparison with the control on the average: stem height – by 2–3 cm, haulm weight – by 65 g/bush, or 13,7 %. The highest coefficient of economic efficiency and yield of dry matter were observed in the variety Farn with preplanting treatment + spraying in the phase of budding – 0,75 and 9,7 t/ha with accumulation of 1,64 % of photosynthetic active radiation in the yield. The increase of the potato yield capacity on the average on the variants of experience is marked on the variety Farn – by 3,6 t/ha, or by 13,5 %; on the variety Barna – by 0,93 t/ha, or by 3,3 %, on the variety Nevskiy – by 1,9 t/ha, or by 7,3 %; starch – by 0,72; 0,25 and 0,55 %; dry matter – by 0,62; 0,42 and 0,43 %, respectively. Costs are recouped in all variants of the experiment compared to the control. Scientific novelty. For the first time in the forest-steppe zone of Republic of North Ossetia – Alania we studied the possibility of using a new generation biopreparation “Bigus, VR” on the potato varieties Farn, Barna and Nevskiy. Practical significance. On the basis of the results of the research in the production of potatoes in the piedmont zone of RNO-Alania can be recommended the use of the biological preparation “Bigus, VR” on potato plantings as a rational and highly effective agrotechnological method.