A field experiment was conducted at Agricultural Research Station, Adilabad, Telangana during Kharif, 2022 to assess the efficacy of new generation herbicides in soybean (Glycine max. L). The experiment was laid out in randomized block design with 11 treatments and replicated thrice. Results revealed that among herbicidal treatments, pre-emergence application of Diclosulam 84% WDG @ 26 g ha-1fb post-emergence of Fluazifop-p-butyl 11.1% w/w + Fomesafen 11.1% w/w SL @ 250 g ha-1 recorded lowest weed density, biomass, weed index and higher weed control efficiency, seed and haulm yield. It was followed by pre-emergence application of Imazethapyr 2% EC + Pendimethalin 30% EC mix @ 960 g ha-1fb post-emergence Fluazifop-p-butyl 11.1% w/w + Fomesafen 11.1% w/w SL @ 250 g ha-1.