Pre-attentive Auditory Processing Research Articles

The time course of hypoxia effects using an aviation survival trainer

IntroductionReduced environmental oxygen levels at high altitudes can result in hypoxic hypoxia, which remains a primary threat in tactical aviation. Hypoxia broadly impairs cognition and can degrade a pilot's ability to safely operate the aircraft. Current hypoxia countermeasures include aircraft life support systems that deliver supplemental oxygen and using controlled hypoxia exposures to train aviators to recognize symptoms. To maximize the effectiveness of these countermeasures, it is critical to understand how hypoxia impacts performance and associated neurocognitive outcomes. We previously showed that a neural marker that indexes sensory processing integrity is sensitive to hypoxia impairment.MethodsHere, we extend this line of research closer to the training environment by using hypoxia simulation equipment currently standard in aviation survival training. In a single-blind, repeated-measures, counterbalanced design, we exposed 34 healthy participants to either normoxic air (ground level) or normobaric hypoxia (altitude equivalent gradually increasing from 10 to 25k') for 20 min after a 10 min baseline at ground level. During the exposure, participants completed a cognitive assessment battery while passively elicited neural responses to auditory tones were recorded using electroencephalography (EEG). Participants reported their hypoxia symptoms throughout and upon completion of their exposures.ResultsWe found that the hypoxia exposure rapidly elicited the predicted physiological responses in peripheral oxygen saturation (decrease) and heart rate (increase) within 2–3 minutes of exposure onset. On average, participants reported hypoxia symptoms in a delayed manner, ~8 min following the exposure onset. Performance on the cognitive tasks was relatively unaffected by hypoxia for basic tasks including Stroop, fine motor tracking, color vision and arithmetic, but was significantly degraded by hypoxia for more advanced tasks that combined a visual search component with Stroop and a working memory task. EEG activity associated with pre-attentive auditory processing was impaired on average shortly after the first symptom report, ~10 min from exposure start.DiscussionTogether, these results move hypoxia research closer to conditions encountered in aviation survival training and support the use of training devices for future hypoxia research.

Effects of the cardiac cycle on auditory processing: A preregistered study on mismatch negativity.

The systolic and diastolic phases of the cardiac cycle are known to affect perception and cognition differently. Higher order processing tends to be facilitated at systole, whereas sensory processing of external stimuli tends to be impaired at systole compared to diastole. The current study aims to examine whether the cardiac cycle affects auditory deviance detection, as reflected in the mismatch negativity (MMN) of the event-related brain potential (ERP). We recorded the intensity deviance response to deviant tones (70 dB) presented among standard tones (60 or 80 dB, depending on blocks) and calculated the MMN by subtracting standard ERP waveforms from deviant ERP waveforms. We also assessed intensity-dependent N1 and P2 amplitude changes by subtracting ERPs elicited by soft standard tones (60 dB) from ERPs elicited by loud standard tones (80 dB). These subtraction methods were used to eliminate phase-locked cardiac-related electric artifacts that overlap auditory ERPs. The endogenous MMN was expected to be larger at systole, reflecting the facilitation of memory-based auditory deviance detection, whereas the exogenous N1 and P2 would be smaller at systole, reflecting impaired exteroceptive sensory processing. However, after the elimination of cardiac-related artifacts, there were no significant differences between systole and diastole in any ERP components. The intensity-dependent N1 and P2 amplitude changes were not obvious in either cardiac phase, probably because of the short interstimulus intervals. The lack of a cardiac phase effect on MMN amplitude suggests that preattentive auditory processing may not be affected by bodily signals from the heart.

Late mismatch negativity of lexical tone at age 8 predicts Chinese children's reading ability at age 10.

Deficits in phonological processing are commonly reported in dyslexia but longitudinal evidence that poor speech perception compromises reading is scant. This 2-year longitudinal ERP study investigates changes in pre-attentive auditory processing that underlies categorical perception of mandarin lexical tones during the years children learn to read fluently. The main purpose of the present study was to explore the development of lexical tone categorical perception to see if it can predict children's reading ability. Both behavioral and electrophysiological measures were taken in this study. Auditory event-related potentials were collected with a passive listening oddball paradigm. Using a stimulus continuum spanning from one lexical tone category exemplar to another, we identified a between-category and a within-category tone deviant that were acoustically equidistant from a standard stimulus. The standard stimulus occurred on 80% of trials, and one of two deviants (between-category or within-category) equiprobably on the remaining trials. 8-year-old Mandarin speakers participated in both an initial ERP oddball paradigm and returned for a 2-year follow-up. The between-category MMN and within-category MMN significantly correlate with each other at age 8 (p = 0.001) but not at age 10. The between-category MMN at age 8 can predict children's ability at age 10 (p = 0.03) but the within-category cannot. The categorical perception of lexical tone is still developing from age 8 to age 10. The behavioral and electrophysiological results demonstrate that categorical perception of lexical tone at age 8 predicts children's reading ability at age 10.

The Relationship Between Affective Visual Mismatch Negativity and Interpersonal Difficulties Across Autism and Schizotypal Traits.

Sensory deficits are a feature of autism and schizophrenia, as well as the upper end of their non-clinical spectra. The mismatch negativity (MMN), an index of pre-attentive auditory processing, is particularly sensitive in detecting such deficits; however, little is known about the relationship between the visual MMN (vMMN) to facial emotions and autism and schizophrenia spectrum symptom domains. We probed the vMMN to happy, sad, and neutral faces in 61 healthy adults (18–40 years, 32 female), and evaluated their degree of autism and schizophrenia spectrum traits using the Autism Spectrum Quotient (AQ) and Schizotypal Personality Questionnaire (SPQ). The vMMN to happy faces was significantly larger than the vMMNs to sad and neutral faces. The vMMN to happy faces was associated with interpersonal difficulties as indexed by AQ Communication and Attention to Detail subscales, and SPQ associated with more interpersonal difficulties. These data suggest that pre-attentive processing of positive affect might be more specific to the interpersonal features associated with autism and schizophrenia. These findings add valuable insights into the growing body of literature investigating symptom-specific neurobiological markers of autism and schizophrenia spectrum conditions.

Machine-learning-based diagnosis of drug-naive adult patients with attention-deficit hyperactivity disorder using mismatch negativity

Relatively little is investigated regarding the neurophysiology of adult attention-deficit/hyperactivity disorder (ADHD). Mismatch negativity (MMN) is an event-related potential component representing pre-attentive auditory processing, which is closely associated with cognitive status. We investigated MMN features as biomarkers to classify drug-naive adult patients with ADHD and healthy controls (HCs). Sensor-level features (amplitude and latency) and source-level features (source activation) of MMN were investigated and compared between the electroencephalograms of 34 patients with ADHD and 45 HCs using a passive auditory oddball paradigm. Correlations between MMN features and ADHD symptoms were analyzed. Finally, we applied machine learning to differentiate the two groups using sensor- and source-level features of MMN. Adult patients with ADHD showed significantly lower MMN amplitudes at the frontocentral electrodes and reduced MMN source activation in the frontal, temporal, and limbic lobes, which were closely associated with MMN generators and ADHD pathophysiology. Source activities were significantly correlated with ADHD symptoms. The best classification performance for adult ADHD patients and HCs showed an 81.01% accuracy, 82.35% sensitivity, and 80.00% specificity based on MMN source activity features. Our results suggest that abnormal MMN reflects the adult ADHD patients’ pathophysiological characteristics and might serve clinically as a neuromarker of adult ADHD.

The lateralization and reliability of spatial mismatch negativity elicited by auditory deviants with virtual spatial location

Mismatch negativity (MMN) is an intensively studied event-related potential component that reflects pre-attentive auditory processing. Existing spatial MMN (sMMN) studies usually use loud-speakers in different locations or deliver sound with binaural localization cues through earphones to elicit MMN, which either was practically complicated or sounded unnatural to the subjects. In the present study, we generated head related transfer function (HRTF)-based spatial sounds and verified that the HRTF-based sounds retained the left and the right spatial localization cues. We further used them as deviants to elicit sMMN with conventional oddball paradigm. Results showed that sMMN was successfully elicited by the HRTF-based deviants in 18 of 21 healthy subjects in two separate sessions. Furthermore, the left deviants elicited higher sMMN amplitudes in the right hemisphere compared to the left hemisphere, while the right deviants elicited sMMN with similar amplitudes in both hemispheres, which supports a combination of contralateral and right-hemispheric dominance in spatial auditory information processing. In addition, the sMMN in response to the right deviants showed good test-retest reliability, while the sMMN in response to the left deviants had weak test-retest reliability. These findings implicate that HRTF-based sMMN could be a robust paradigm to investigate spatial localization and discrimination abilities.

The Interaction Between Timescale and Pitch Contour at Pre-attentive Processing of Frequency-Modulated Sweeps

Speech comprehension across languages depends on encoding the pitch variations in frequency-modulated (FM) sweeps at different timescales and frequency ranges. While timescale and spectral contour of FM sweeps play important roles in differentiating acoustic speech units, relatively little work has been done to understand the interaction between the two acoustic dimensions at early cortical processing. An auditory oddball paradigm was employed to examine the interaction of timescale and pitch contour at pre-attentive processing of FM sweeps. Event-related potentials to frequency sweeps that vary in linguistically relevant pitch contour (fundamental frequency F0 vs. first formant frequency F1) and timescale (local vs. global) in Mandarin Chinese were recorded. Mismatch negativities (MMNs) were elicited by all types of sweep deviants. For local timescale, FM sweeps with F0 contours yielded larger MMN amplitudes than F1 contours. A reversed MMN amplitude pattern was obtained with respect to F0/F1 contours for global timescale stimuli. An interhemispheric asymmetry of MMN topography was observed corresponding to local and global-timescale contours. Falling but not rising frequency difference waveforms sweep contours elicited right hemispheric dominance. Results showed that timescale and pitch contour interacts with each other in pre-attentive auditory processing of FM sweeps. Findings suggest that FM sweeps, a type of non-speech signal, is processed at an early stage with reference to its linguistic function. That the dynamic interaction between timescale and spectral pattern is processed during early cortical processing of non-speech frequency sweep signal may be critical to facilitate speech encoding at a later stage.

Combination of absolute pitch and tone language experience enhances lexical tone perception

Absolute pitch (AP), a unique ability to name or produce pitch without any reference, is known to be influenced by genetic and cultural factors. AP and tone language experience are both known to promote lexical tone perception. However, the effects of the combination of AP and tone language experience on lexical tone perception are currently not known. In the current study, using behavioral (Categorical Perception) and electrophysiological (Frequency Following Response) measures, we investigated the effect of the combination of AP and tone language experience on lexical tone perception. We found that the Cantonese speakers with AP outperformed the Cantonese speakers without AP on Categorical Perception and Frequency Following Responses of lexical tones, suggesting an additive effect due to the combination of AP and tone language experience. These findings suggest a role of basic sensory pre-attentive auditory processes towards pitch encoding in AP. Further, these findings imply a common mechanism underlying pitch encoding in AP and tone language perception.

Classification of First-Episode Schizophrenia, Chronic Schizophrenia and Healthy Control Based on Brain Network of Mismatch Negativity by Graph Neural Network.

Mismatch negativity (MMN) has been consistently found deficit in schizophrenia, which was considered as a promising biomarker for assessing the impairments in pre-attentive auditory processing. However, the functional connectivity between brain regions based on MMN is not clear. This study provides an in-depth investigation in brain functional connectivity during MMN process among patients with first-episode schizophrenia (FESZ), chronic schizophrenia (CSZ) and healthy control (HC). Electroencephalography (EEG) data of 128 channels is recorded during frequency and duration MMN in 40 FESZ, 40 CSZ patients and 40 matched HC subjects. We reconstruct the cortical endogenous electrical activity from EEG recordings using exact low-resolution electromagnetic tomography and build functional brain networks based on source-level EEG data. Then, graph-theoretic features are extracted from the brain networks with the support vector machine (SVM) to classify FESZ, CSZ and HC groups, since the SVM has good generalization ability and robustness as a universally applicable nonlinear classifier. Furthermore, we introduce the graph neural network (GNN) model to directly learn for the network topology of brain network. Compared to HC, the damaged brain areas of CSZ are more extensive than FESZ, and the damaged area involved the auditory cortex. These results demonstrate the heterogeneity of the impacts of schizophrenia for different disease courses and the association between MMN and the auditory cortex. More importantly, the GNN classification results are significantly better than those of SVM, and hence the EEG-based GNN model of brain networks provides an effective method for discriminating among FESZ, CSZ and HC groups.

Predictability of higher-order temporal structure of musical stimuli is associated with auditory evoked response

Sound predictability resulting from repetitive patterns can be implicitly learned and often neither requires nor captures our conscious attention. Recently, predictive coding theory has been used as a framework to explain how predictable or expected stimuli evoke and gradually attenuate obligatory neural responses over time compared to those elicited by unpredictable events. However, these results were obtained using the repetition of simple auditory objects such as pairs of tones or phonemes. Here we examined whether the same principle would hold for more abstract temporal structures of sounds. If this is the case, we hypothesized that a regular repetition schedule of a set of musical patterns would reduce neural processing over the course of listening compared to stimuli with an irregular repetition schedule (and the same set of musical patterns). Electroencephalography (EEG) was recorded while participants passively listened to 6–8 min stimulus sequences in which five different four-tone patterns with temporally regular or irregular repetition were presented successively in a randomized order. N1 amplitudes in response to the first tone of each musical pattern were significantly less negative at the end of the regular sequence compared to the beginning, while such reduction was absent in the irregular sequence. These results extend previous findings by showing that N1 reflects automatic learning of the predictable higher-order structure of sound sequences, while continuous engagement of preattentive auditory processing is necessary for the unpredictable structure.

Impaired Sensory Processing During Low-Oxygen Exposure: A Noninvasive Approach to Detecting Changes in Cognitive States.

The ability to detect novelty in our environment is a critical sensory function. A reliable set of event-related potentials (ERP), known as the auditory deviance response (ADR), are elicited in the absence of directed attention and indexes functionally relevant networks. The ADR consists of three peaks: mismatch negativity (MMN), P3a, and reorienting negativity (RON) that are sequentially evoked in response to unattended changes in repetitive background stimulation. While previous studies have established the ADR’s sensitivity to a range of pharmacologic and nonpharmacologic interventions and are leading candidate biomarkers of perturbations of the central nervous system (CNS), here we sought to determine if ADR peaks are sensitive to decreases in breathable oxygen. Participants performed a visuomotor tracking task while EEG was recorded during two 27-min sessions. The two sessions differed in the amount of environmental oxygen available: 10.6% O2 (hypoxia) versus 20.4% O2 (normoxia). ERPs were measured while a series of identical, or “standard,” tones combined with occasional “oddball,” tones, were presented. MMN, P3a, and RON were assessed in response to the oddball compared to the standard stimuli. Behavioral impairment during hypoxia was demonstrated by a deficit in tracking performance compared to the normoxia condition. Whereas no changes were detected in the MMN or RON, the amplitude of the P3a component was significantly reduced during hypoxia compared to normoxia, within the first 9 min of exposure. To our knowledge, this is the first study to demonstrate the effect of low oxygen exposure on passively elicited neural measures of early sensory processing. This study demonstrates that passively elicited EEG measures, reflecting preattentive auditory processing, are disrupted by acute hypoxia. Results have implications for the development of biomarkers for the noninvasive assessment of CNS perturbations.

P.208 Cortical excitation-inhibition ratios mediate the extent to which pre-attentive auditory processing deficits predict psychosocial difficulties

P.208 Cortical excitation-inhibition ratios mediate the extent to which pre-attentive auditory processing deficits predict psychosocial difficulties

Cortical excitation-inhibition ratio mediates the effect of pre-attentive auditory processing deficits on interpersonal difficulties

Several lines of evidence identify aberrant excitatory-inhibitory neural processes across autism and schizophrenia spectrum disorders, particularly within the psychosocial domain. Such neural processes include increased excitatory glutamate and reduced inhibitory GABA concentrations, which may affect auditory pre-attentive processing as indexed by the mismatch negativity (MMN); thus, an excitation-inhibition imbalance might lead to aberrant MMN, which might in turn drive the relationship between the MMN and psychosocial difficulties. This research has the potential to enhance the neurochemical understanding of the relationship between electrophysiology (MMN) and behavioural/clinical measures (psychosocial difficulties).Thirty-eight adults (18 male, 18–40 years) completed the Schizotypal Personality Questionnaire (SPQ) and Autism-Spectrum Quotient (AQ). Glutamate and GABA concentrations in bilateral superior temporal cortex (STC) were quantified using proton magnetic resonance spectroscopy (1H-MRS) while auditory MMN to a duration deviant was measured with magnetoencephalography. Spearman correlations probed the relationships between STC glutamate/GABA ratios, MMN amplitude and latency, and AQ and SPQ dimensions. Mediation effects of glutamate/GABA ratios on the relationship between MMN and AQ-SPQ dimensions were probed using causal mediation analysis.Only SPQ-interpersonal and AQ-communication were significantly correlated with right hemisphere glutamate/GABA ratios and MMN latency (ps < 0.05), which were themselves correlated (p = .035). Two mediation models were investigated, with right MMN latency as predictor and SPQ-interpersonal and AQ-communication as outcome variables. Right STC glutamate/GABA ratios significantly mediated the relationship between MMN latency and SPQ-interpersonal scores, but only partially mediated the relationship between MMN latency and AQ-communication scores.These findings support the growing body of literature pointing toward an excitation-inhibition imbalance that is central to psychosocial functioning across multi-dimensional spectrum disorders, such as autism and schizophrenia, and provides neurochemical indicators of the processes that underlie psychosocial dysfunction.

Auditory gating in adults with dyslexia: An ERP account of diminished rapid neural adaptation

ObjectiveA recent functional magnetic resonance imaging (fMRI) study of adults with dyslexia showed a general deficit in suppressing responses to various types of repetitive stimuli. This diminished neural adaptation may interfere with implicit learning and forming stable word representations. With fMRI, spatial but not temporal characteristics of the adaptation response could be identified. We address this knowledge gap using event-related potentials. MethodsFourteen adults with dyslexia and 14 controls participated in an auditory gating paradigm using tone pairs. Response amplitudes and latencies for N1 and P2 were measured. Participants also compared word pairs consisting of identical or subtly different words, a task requiring stable word representations. ResultsOnly the controls showed a robust gating effect in an attenuated N1 response to the second tone relative to the first. The dyslexia group was less accurate than the controls in detecting word differences. The N1 gating magnitude was associated with this detection accuracy. ConclusionsNeural adaptation occurs by approximately 100 ms after stimulus presentation and is diminished in adults with dyslexia. This complements fMRI findings of relevant brain regions by implying a time window representing sensory and pre-attentive auditory processes. SignificanceThe association between gating magnitude and word discrimination contributes to a neurophysiological account of underspecified word representations.

Interaction of Self-Regulation and Contextual Effects on Pre-attentive Auditory Processing: A Combined EEG/ECG Study

Environmental changes are not always within the focus of our attention, and sensitive reactions (i.e., quicker and stronger responses) can be essential for an organism's survival and adaptation. Here we report that neurophysiological responses to sound changes that are not in the focus of attention are related to both ambient acoustic contexts and regulation ability. We assessed electroencephalograph (EEG) mismatch negativity (MMN) latency and amplitude in response to sound changes in two contexts: ascending and descending pitch sequences while participants were instructed to attend to muted videos. Prolonged latency and increased amplitude of MMN at fronto-central region occurred in ascending pitch sequences relative to descending sequences. We also assessed how regulation related to the contextual effects on MMN. Reactions to changes in the ascending sequence were observed with the attention control (frontal EEG theta/beta ratio) indicating speed of reaction, and the autonomous regulation (heart-rate variability) indicating intensity of reaction. Moreover, sound changes in the ascending context were associated with more activation of anterior cingulate cortex and insula, suggesting arousal effects and regulation processes. These findings suggest that the relation between speed and intensity is not fixed and may be modified by contexts and self-regulation ability. Specifically, cortical and cardiovascular indicators of self-regulation may specify different aspects of response sensitivity in terms of speed and intensity.

Attenuated mismatch negativity in patients with first-episode antipsychotic-naive schizophrenia using a source-resolved method.

BackgroundMismatch negativity (MMN) is a measure of pre-attentive auditory information processing related to change detection. Traditional scalp-level EEG methods consistently find attenuated MMN in patients with chronic but not first-episode schizophrenia. In the current paper, we use a source-resolved method to assess MMN and hypothesize that more subtle changes can be identified with this analysis method.MethodFifty-six first-episode antipsychotic-naïve schizophrenia (FEANS) patients (31 males, 25 females, mean age 24.6) and 64 matched controls (37 males, 27 females, mean age 24.8) were assessed for duration-, frequency- and combined-type MMN and P3a as well as 4 clinical, 3 cognitive and 3 psychopathological measures. To evaluate and correlate MMN at source-level, independent component analysis (ICA) was applied to the continuous EEG data to derive equivalent current dipoles which were clustered into 19 clusters based on cortical location.ResultsNo scalp channel group MMN or P3a amplitude differences were found. Of the localized clusters, several were in or near brain areas previously suggested to be involved in the MMN response, including frontal and anterior cingulate cortices and superior temporal and inferior frontal gyri. For duration deviants, MMN was attenuated at the right superior temporal gyrus in patients compared to healthy controls (p = 0.01), as was P3a at the superior frontal cortex (p = 0.01). No individual patient correlations with clinical, cognitive, or psychopathological measures survived correction for multiple comparisons.ConclusionAttenuated source-localized MMN and P3a peak contributions can be identified in FEANS patients using a method based on independent component analysis (ICA). This indicates that deficits in pre-attentive auditory information processing are present at this early stage of schizophrenia and are not the result of disease chronicity or medication. This is to our knowledge the first study on FEANS patients using this more detailed method.

Atypical perceptual and neural processing of emotional prosodic changes in children with autism spectrum disorders

ObjectiveThe present study explored the processing of emotional speech prosody in school-aged children with autism spectrum disorders (ASD) but without marked language impairments (children with ASD [no LI]). MethodsThe mismatch negativity (MMN)/the late discriminative negativity (LDN), reflecting pre-attentive auditory discrimination processes, and the P3a, indexing involuntary orienting to attention-catching changes, were recorded to natural word stimuli uttered with different emotional connotations (neutral, sad, scornful and commanding). Perceptual prosody discrimination was addressed with a behavioral sound-discrimination test. ResultsOverall, children with ASD (no LI) were slower in behaviorally discriminating prosodic features of speech stimuli than typically developed control children. Further, smaller standard-stimulus event related potentials (ERPs) and MMN/LDNs were found in children with ASD (no LI) than in controls. In addition, the amplitude of the P3a was diminished and differentially distributed on the scalp in children with ASD (no LI) than in control children. ConclusionsProcessing of words and changes in emotional speech prosody is impaired at various levels of information processing in school-aged children with ASD (no LI). SignificanceThe results suggest that low-level speech sound discrimination and orienting deficits might contribute to emotional speech prosody processing impairments observed in ASD.

Does a pitch center exist in auditory cortex? A mismatch negativity study

Pitch sensation can be evoked by different acoustic cues which should be processed by different strategies for extracting pitch. However, in resent studies a general pitch center was hypothesized exist at some level of the auditory pathway for a general pitch sensation independent of other acoustic features. In this study, the existence of pitch center was examined by testing that whether the mismatch negativity (MMN) response, an index of pre-attentive auditory processing, can be elicited by pitch deviations in a passive oddball paradigm that composed of four different pitch-evoking stimuli (i.e., sinusoidal tone, resolved complex, iterated rippled noise, and pulse train). Although the pitch-evoking cues in these pitch-evoking stimuli were disparate, they evoked a fixed pitch of 200 Hz (or 283 Hz in a reversed oddball paradigm). Occasionally a deviant sound was encountered which evoked a different pitch (283 Hz, or 200 Hz in the reversed oddball paradigm). The results showed no significant MMN response was elicited by the deviant, regardless of the type of pitch-evoking stimuli, suggesting the absence of pitch center in the pre-attentive auditory processing stage.

Effects of Visual Game Experience on Auditory Processing Speed.

Games are one of the fastest growing and most exciting forms of entertainment. Whether casual mobile game playing has a cognitive, physiological, or behavioral effect on players whose game use is not pathological is unknown. Here we explored whether preattentive auditory processing is linked to the behavioral inhibition system (BIS) in frequent and infrequent game players. A total of 74 subjects who were enrolled in our study were divided into two groups, 40 subjects were frequent gamers and 34 subjects were age-, gender-, IQ-, and education-matched infrequent gamers. All participants underwent a passive auditory oddball paradigm and completed the behavioral inhibition/behavioral activation system scales. The mismatch negativity (MMN) latency was shorter for the frequent gamers relative to the infrequent gamers, whereas no difference in MMN amplitude was found between groups. MMN amplitude was negatively associated with the degree of behavioral inhibition in the frequent and infrequent gaming group. We also found that those who frequently play games show an enhanced processing speed, which could be an effect of game practice. Greater behavioral inhibition induces increased vigilance, and this may have enhanced the MMN amplitude in the infrequent gamers. This differential pattern of correlations suggests that differences in the BIS could lead to different approaches to auditory information processing.

THU0313 Impaired Pre-Attentive Auditory Processing in Fibromyalgia: A Mismatch Negativity Study

BackgroundFibromyalgia (FM) is characterized by chronic widespread pain. Patients are more sensitive to sensory stimulation regardless of type and modality, suggesting generalized dysfunction in sensory processing. Mismatch Negativity (MMN) is...