Smart instruments, sensors, and AI technologies are playing an important role in many fields such as medical science, Earth science, astronomy physics, and space study. This article attempts to study the role of sensors, instruments, and AI (artificial intelligence) based smart technologies in lunar missions during navigation of trajectories. Lunar landing missions usually divide the power descent phase into three to four sub-phases. Each sub-phase has its own set of initial and final constraints for the desired system state. The landing systems depend on human competencies for making the most crucial landing decisions. Trajectory planning and designing are very significant in lunar missions, and it requires inputs with precision. The manual systems may be prone to errors. In contrast, AI and smart sensor-based measurements give an accurate idea about the trajectory paths and make appropriate decisions where manual systems may turn into disasters. The manual systems are either pre-fed or have manual controls to guide the trajectory. For autonomous landing problems, trajectory design is a very crucial task. The automated trajectories play a vital role in the measurement and prediction of landing state parameters of the space rocket. Nowadays, sensors, intelligent instruments, and the latest technologies go hand in hand to devise measurement methods for accurate calculations and make appropriate decisions during landing space rockets at the designated destination. Space missions are very expensive and require huge efforts to design smart systems for navigation trajectories. This paper attempts to design all possible candidates of reference navigation trajectories for autonomous lunar descent by employing 3D non-linear system dynamics with randomly chosen initial state conditions. The generated candidates do not rely on multiple hops and thus exhibit an ability to serve autonomous missions. This research work makes use of smart sensors and AI federated techniques for smartly training the system to serve the ultimate purpose. The trajectories are simulated in an automated simulating environment to perform exhaustive analyses. The results accurately approximate the trajectories analogous to their numerical counterparts and converge to their measured final state estimates. The generation rate of feasible trajectories measures the accuracy of the algorithm. The algorithm’s accuracy is near 0.87 for 100 sec flight time, which is reasonable.