This study explores the nonlinear effects of hydrodynamic loads and hydroelastic responses in monopile-supported offshore wind turbines, with a focus on their harmonic structures. High-quality experimental data were collected in a shallow water basin across various irregular waves. Their harmonic components up to the fourth order were successfully isolated using a novel four-phase decomposition technique, which effectively extracts harmonics from random time series. The results highlight significant contributions of higher-order harmonics across various sea states. Specifically, two physical models were employed: a flexible monopile to capture structural hydroelastic deformations during large wave events and a rigid monopile to accurately estimate hydrodynamic loads without hydroelastic effects. Additionally, numerical results from fully nonlinear potential-flow calculations were compared, revealing that while the potential-flow solver underestimates total wave loading, especially for higher harmonics. In terms of the free-surface elevations and hydrodynamic forces, this study confirms that their higher-order harmonics align well with the scaling of their corresponding linear components in both amplitude and phase. This enables the prediction of higher-order profiles based solely on their linear components. However, this efficient model is inadequate for accurately estimating the higher-order harmonics of monopile's hydroelastic responses during these extreme wave events, highlighting the need for further refinement.