The impact of COVID-19 grew worse by its quick onset, the overwhelming number of patients in need of urgent care, and the lack of awareness of its signs beforehand. It mostly affected the respiratory system, making respiratory rehabilitation extremely important. This study was carried out to see the effectiveness of breathing exercises along with the postural changes in COVID-19 patients under acute hospital care. A total of 40 subjects with age group between 18 years to 60 years, diagnosed with COVID-19 were included according to the selection criteria and were divided into 2 equal groups of 20 subjects each. The subjects in Group A received positioning protocol while those in Group B received breathing exercises along with positioning protocol. After 7 days of intervention, the mean SpO2(88.6% vs 89.9%, P<0.001) and pulse rate (82 vs 91 beats/minute, P<0.001) for Group A and Group B respectively. This study concluded that breathing exercises along with postural changes in patients hospitalized with COVID-19 is an effective rehabilitation program for improving SPO2 levels and pulse rate. KEYWORDS: Breathing exercises, COVID-19, Postural changes, Respiratory rehabilitation.