In the field of seismic data processing, seismic denoising is essential to improve the quality of seismic data. Various deep learning methods have been proposed, showing promising performance for seismic denoising. However, most deep learning methods are based on lin ear neurons, resulting in limited expressive ability for complex seismic signals. To enhance denoising capability using non-linear neurons, we propose a supervised quadratic U-shaped network (QUnet) for seismic random noise attenuation. The quadratic neurons in QUnet are represented by a second-order polynomial of input data and weighted parameters. Nu merical synthetic seismic data experiments show that the proposed QUnet method achieves higher signal-to-noise ratio results and preserves the continuity of reflectors more effectively. We have also tested the effectiveness of QUnet on both prestack field data and post-stack seismic data. The detailed structures and weak signals of seismic data are better preserved by our proposed QUnet method.