Introduction: Splenic pseudo cysts are extremely uncommon. Most of these cysts are asymptomatic and may result from previous blunt abdominal trauma. We report an interesting uncommon case of a large splenic pseudo cyst without a history of previous abdominal trauma. Case Presentation: 44 years old female with normal BMI, married, non-smoker, non-alcoholic, and housewife. She had no past medical or surgical history and was not on any oral medications. She presented with upper abdominal pain and discomfort for 6 months. Irregular pain with mild intensity associated with shortness of breath, her physical examination was unremarkable. The abdominal ultrasound and contras-enchased CT showed a large splenic cyst occupying the lower pole of the spleen, Echinococcus multilocularis antibody test was negative (Titer<1:16), Thus the Echinococcosis was excluded from the differential diagnosis. The differential diagnosis, in this case, was a non-parasitic splenic cyst. The patient underwent elective diagnostic laparoscopic with laparoscopic splenectomy. Discussion: The patient had an uneventful postoperative recovery course. He was discharged from the hospital on the third postoperative day (within the expected time frame), and instructed to avoid heavy lifting for a few months and to complete the post-splenectomy vaccination protocol. Conclusion: Pseudocyst of the spleen is quite uncommon in routine clinical practice and should be differentiated from more common lesions such as hydatid cysts, abscess of the spleen, etc. The Pseudocyst of the spleen is usually asymptomatic and is detected incidentally during the abdominal scan for other reasons. Splenectomy is the gold standard treatment for splenic pseudocysts. Partial splenectomy is the recommended procedure if at least 25% of splenic parenchyma is achievable.