AbstractThe Spanish historical earthquake catalog reveals a significant number of destructive earthquakes (Mw 6.0) that have occurred along the Eastern Betic Shear Zone (EBSZ), a major active fault system at the Eastern Betic Cordillera. However, during the last century, seismic activity in this region has been characterized by the absence of large‐magnitude events, complicating yet underlining the importance of understanding active fault interaction in the EBSZ. In this work, we focus on the northeastern half of the EBSZ and apply a similar method to Yazdi et al. (2023, https://doi.org/10.1029/2023tc007917). We model a series of consecutive earthquakes ( VII; Mw 5.0) between the and centuries occurring along the Alhama de Murcia, Carrascoy and Bajo Segura faults, and assess their coseismic impact as well as explore the evolution of Coulomb stress changes due to the postseismic viscoelastic relaxation on the surrounding faults. Our results support a stress‐triggering connection between subsequent events and shed light on identifying the responsible faults for some. Our findings indicate that 1673 Mw 6.0 Orihuela and 1674 Mw 6.2 Lorca earthquakes, seemingly unrelated, could have both contributed to the forthcoming Mw 5.0 earthquake clustering along the Carrascoy fault. We show that attributing the 1829 Mw 6.6 Torrevieja earthquake to the Bajo Segura fault better describes the occurrence of earthquake sequences between the mid‐ and early centuries. Finally, we propose the Alhama de Murcia and the Carrascoy faults as responsible initiators for the early ‐century earthquake sequence in the Segura Medio valley. These findings provide valuable insights for seismic hazard modeling in the region.