Postoperative Topical Treatment Research Articles

Acute Serous Retinal Detachment after the Same Operating Session of Uncomplicated Cataract Surgeries: A Case Series.

To report four cases of acute serous retinal detachment (ASRD) after the same operating session of uncomplicated cataract surgeries. In this case series, data of patients who developed ASRD after uncomplicated phacoemulsification with intraocular lens implantation during the same operating session were collected. Diagnosis was made on the first postoperative day, when all patients had a very low best-corrected visual acuity (BCVA), despite a good aspect of the anterior segment, without significant keratopathy and with only trace cells in the anterior chamber. Spectral-domain optic coherence tomography (SD-OCT) revealed serous retinal detachment with subretinal fluid accumulation in the macular area. Patients received a parabulbar injection of 40 mg/mL triamquinolone in addition to usual the postoperative topical treatment of 0.1% dexamethasone and 0.3% netilmicin eye drops. Patients were examined postoperatively on days 1, 3, 7, and 1 month. BCVA and central foveal thickness (CFT) measured by SD-OCT were evaluated at each visit. A relationship between demographics, preoperative ocular conditions, systemic diseases, parameters of surgery, and the development of ASRD was analyzed. After a single operating session of 10 uneventful cataract surgeries, operated by the same expert surgeon, on postoperative day 1, ASRD was detected in 4 patients (3 male, 1 female; mean age 71 ± 4.1 years). Preoperatively, the mean BCVA was 0.6 ± 0.1 decimals and mean CFT was 191.3 ± 13.7 µm. On the first postoperative day, mean BCVA was 0.01 ± 0.1 decimals, and all eyes had serous retinal detachment, with a mean CFT of 682.0 ± 97.4 µm. On the following visits, BCVA improved and CFT reduced significantly. On day 7, BCVA was at least 0.7 decimals in all eyes, with complete reabsorption of subretinal fluid. At 1 month, mean BCVA was 1.0 ± 0.0 decimals and no eye had recurrence of serous retinal detachment, with a mean CFT of 202.3 ± 26.7 µm. No relevant data were found on other parameters investigated. Acute serous retinal detachment is a rare event that can occur after uncomplicated phacoemulsification, which in our cases, resolved in a few days without recurrence.

Efficacy of Topical High Volume Budesonide Nasal Irrigation in Post FESS Patients of Chronic Rhinosinusitis With or Without Nasal Polyposis.

Chronic rhinosinusitis (CRS) is a chronic inflammatory process of nasal mucosa and paranasal sinuses, lasting more than 12weeks, without complete resolution of symptoms. CRS is treated medically, followed by Endoscopic sinus surgery (ESS) if necessary, and supplemented by post-operative topical treatment with highly variable clinical outcomes. However, till date there is no consensus on the composition and duration of maximal medical treatment. Despite proven role of topical steroids, the mode of delivery, dose and duration of topical intranasal corticosteroids still remains debatable. Studies found that high volume sinonasal irrigation (> 50ml) using budesonide is most efficient method but still there is not sufficient data to prove this and results are variable with multiple modifiable factors therefore, this study has been conducted. (1) To determine the difference in mean decrease in Lund-Kennedy endoscopic scores and SNOT-22 scores among post ESS patients with high volume budesonide nasal irrigation nasal cavity and control nasal cavity of chronic rhinosinusitis patients. (2) To determine safety by measuring serum cortisol levels and intra ocular pressure. This is hospital based interventional, randomised, double blind, control trial study. A total of 66 patients of CRS with previous failed medical therapy were included. Same patients nasal cavities were divided into control and case nasal cavities, to avoid demographic bias. All subjects had a baseline SNOT-22 scores (Sino Nasal Outcome Test scores), Lund Kennedy endoscopy score, NCCT PNS score. All patients were undergone ESS procedure. After nasal pack removal, nasal cavities were randomly assigned 1:1 to receive normal saline irrigation (control group) or 1mg of budesonide irrigation (case group) for transnasal irrigation twice daily for 12weeks. A total of 66 patients with 132 nasal cavities were included in the study. Out of which 16 were female and 50 were male with mean age 33year and mean duration of symptoms was 38.19months. Mean duration of follow up was for 3months. Mean decrement in SNOT-22 score in control nasal cavity from 52.54(16.309) to 30.06 (18.16) and in endoscopic score from 6.53 (1.33) to 3.93 (1.6) which is statically significant (p value < 0.05) in both scores. Mean decrement in SNOT-22 score in case nasal cavity from 53.73 (15.75) to 21.15 (13.52) and in endoscopic score from 6.74 (1.8) to 2.77 (1.4) which is statically significant (p value < 0.05) in both scores. Decrement in SNOT-22 scores and endoscopy scores in case nasal cavity in comparision to control nasal cavity were compared by student 't' test and found to be statically significant (p value equals to 0.0001). In subjective outcomes 57.57% shows total improvement in control nasal cavities while 72.73% case nasal cavities shows total improvement. Our study shows high volume budesonide irrigation is safe and superior over normal saline irrigation and results were statistically comparable. Still further studies with larger sample size and longer duration of irrigation needed.Based on available evidence, high volume budesonide irrigation is statically safe and superior over normal saline irrigation.

Prophylactic intracameral cefazolin and postoperative topical moxifloxacin after cataract surgery: endophthalmitis risk reduction and safety results in a 16-year study.

This large retrospective observational study describes the evolution of the rates of postoperative endophthalmitis in cataract surgery in a 16-year period, and compares them before and after two different changes in the prophylaxis protocol of a general hospital in Barcelona, Spain. This study included all the phacoemulsification procedures performed from January 2002 to December 2017. In January 2004, intracameral cefazolin at the end of the surgery was added to the prophylaxis protocol of cataract surgery. In January 2011, topical postoperative ofloxacin was replaced by topical moxifloxacin. Cumulative incidences of postoperative endophthalmitis before and after the addition of intracameral cefazolin and the change of ofloxacin by moxifloxacin as postoperative topical treatment were compared. The study included 55,984 surgeries. In the period after the introduction of intracameral cefazolin (2004-2010), the cumulative incidence of endophthalmitis was 0.047% (95% CI 0.019-0.099%), significantly lower than in the previous period. From January 2011 to December 2017, after the postoperative change of topical ofloxacin by moxifloxacin, the cumulative incidence dropped to 0.0037% (95% CI 0.000468-0.01862%), with a relative risk reduction between both periods of 91.3%. An intracameral bolus of cefazolin was a very effective prophylaxis of endophthalmitis in cataract surgery. The continuous surveillance and prophylaxis protocol revision over time further reduced the incidence of this complication to extremely low levels.

Removal of Congenital Middle-ear Cholesteatoma via Transcanal Myringectomy in Infants

Postoperative topical ear treatment in infants is often difficult and troublesome. We removed congenital middle-ear cholesteatoma via partial transcanal myringectomy in 3 infants. Subjects were 2 boys and a girl aged 2–3 years. Two also had bilateral secretory otitis media. Cholesteatoma was closed type and was confined to the mesotympanum in all cases—the anterosuperior quadrant in 2 and the anterosuperior-anteroinferior quadrants in one. Operative procedure was as follows: the tympanic membrane was partially resected in proportion to cholesteatoma size without elevating ear canal skin. Cholesteatoma was removed through the perforation created, followed by immediate underlay myringoplasty using a temporal fascia graft. To eliminate postoperative topical treatment, no packing was placed in the ear canal. The fascia graft epithelialized satisfactorily in the three cases. The postoperative clinical course of two subjects has been uneventful in 10 to 13 months of follow-up. The third infant developed recurrent cholesteatoma and underwent a second operation 15 months after the first surgery. No re-recurrence has been seen in the 14 months since reoperation. Our approach involves minimal surgical invasion, requires no postoperative topical treatment, and is thus useful in removing congenital cholesteatoma confined to the mesotympanum, particularly in infants.

The role of antimetabolites in filtration surgery for neovascular glaucoma: intermediate‐term follow‐up

To compare the intermediate-term efficacy of 5-fluorouracil (5-FU) and Mitomycin C (MMC) as adjunctive antimetabolites in neovascular glaucoma (NVG) filtration surgery. Forty consecutive eyes of 40 patients with NVG refractory to medical therapy were randomized to receive antimetabolite-augmented trabeculectomy. Eighteen eyes received postoperative 5-FU (5-FU group) and 22 eyes received intraoperative, low-dose (0.2 mg/ml) MMC for 2 mins (MMC group). The main outcome measure was intraocular pressure (IOP). Surgical success was defined as IOP < 21 mmHg with topical treatment (qualified success) or without topical treatment (complete success). Surgical failure was defined as IOP > or = 21 mmHg, despite postoperative topical treatment, and by postoperative blindness. The mean follow-up period was 35.8 +/- 22.6 months in the 5-FU group and 18.6 +/- 17.2 months in the MMC group. This difference was not significant. Mean IOP decreased from 40.4 +/- 10.3 mmHg to 14.7 +/- 3.4 mmHg (p < 0.0001) in the 5-FU group and from 42 +/- 11.3 mmHg to 22.9 +/- 13.3 mmHg (p = 0.0006) in the MMC group; however, the difference between the 5-FU and MMC groups was not significant at any point. The success rate in the 5-FU group was 55.5% (44.4% complete, 11.1% qualified), compared with 54.5% (9.1% complete, 45.4% qualified) in the MMC group. This difference was not significant. The percentage of patients who achieved postoperative IOP < 21 mmHg was similar in both groups, although a larger proportion of patients treated with MMC-augmented trabeculectomy required topical treatment in comparison with the 5-FU group.

Effect of Diclofenac on Corneal Haze after Photorefractive Keratectomy in Rabbits

To evaluate the ability of topical diclofenac to decrease corneal opacity after excimer laser photorefractive keratectomy (PRK). Twenty New Zealand white rabbits underwent a unilateral 193-nm excimer laser myopic photorefractive keratectomy to correct 5 diopters. There were four groups of five rabbits each. The first group of rabbits received postoperative topical treatment with placebo (Voltaren Ophthalmic vehicle), the second group received topical 0.1% diclofenac, the third group received topical corticosteroid (0.1% fluorometholone), and the fourth group received diclofenac and fluorometholone. In the first month, the topical drugs were applied four times daily, and in the second month twice daily. Corneal haze was graded from 0 (totally clear) to 4 (completely opaque cornea). Slit-lamp pictures were obtained at weeks 2, 4, and 8, and keratometry readings was performed at weeks 4 and 8. At week 8, the rabbits were killed, and the eyes were submitted for histologic examination. At week 8, there was less corneal haze in the diclofenac-treated animals and in the fluorometholone-treated animals than in the control group, but only in the diclofenac-treated group was the difference statistically significant. Combination treatment with diclofenac and fluorometholone did not result in a further decrease in haze. These data suggest that diclofenac and fluorometholone may influence corneal wound healing in rabbits after excimer laser PRK and support a potential role for using topical nonsteroidal anti-inflammatory drugs in preventing the development of excessive corneal haze after excimer laser surgery.