Posterior N1 Research Articles

Visual selective attention in individuals with age-related hearing loss

Evidence from epidemiological studies suggests that hearing loss is associated with an accelerated decline in cognitive function, but the underlying pathophysiological mechanism remains poorly understood. Studies using auditory tasks have suggested that degraded auditory input increases the cognitive load for auditory perceptual processing and thereby reduces the resources available for other cognitive tasks. Attention-related networks are among the systems overrecruited to support degraded auditory perception, but it is unclear how they function when no excessive recruitment of cognitive resources for auditory processing is needed. Here, we implemented an EEG study using a nonauditory visual attentional selection task in 30 individuals with age-related hearing loss (ARHLs, 60–73 years) and compared them with aged (N = 30, 60–70 years) and young (N = 35, 22–29 years) normal-hearing controls. Compared with their normal-hearing peers, ARHLs demonstrated a significant amplitude reduction for the posterior contralateral N2 component, which is a well-validated index of the allocation of selective visual attention, despite the comparable behavioral performance. Furthermore, the amplitudes were observed to correlate significantly with hearing acuities (pure tone audiometry thresholds) and higher-order hearing abilities (speech-in-noise thresholds) in aged individuals. The target-elicited alpha lateralization, another mechanism of visuospatial attention, demonstrated in control groups was not observed in ARHLs. Although behavioral performance is comparable, the significant decrease in N2pc amplitude in ARHLs provides neurophysiologic evidence that may suggest a visual attentional deficit in ARHLs even without extra-recruitment of cognitive resources by auditory processing. It supports the hypothesis that constant degraded auditory input in ARHLs has an adverse impact on the function of cognitive control systems, which is a possible mechanism mediating the relationship between hearing loss and cognitive decline.

Processing of visual hapaxes in picture naming task: An event-related potential study

Object recognition and visual categorization are typically swift and seemingly effortless tasks that involve numerous underlying processes. In our investigation, we utilized a picture naming task to explore the processing of rarely encountered objects (visual hapaxes) in comparison to common objects. Our aim was to determine the stage at which these rare objects are classified as unnamable. Contrary to our expectations and in contrast to some prior research on event-related potentials (ERPs) with novel and atypical objects, no differences between conditions were observed in the late time windows corresponding to the P300 or N400 components. However, distinctive patterns between hapaxes and common objects surfaced in three early time windows, corresponding to the posterior N1 and P2 waves, as well as a widespread N2 wave. According to the ERP data, the differentiation between hapaxes and common objects occurs within the first 380 ms of the processing line, involving only limited and indirect top-down influence.

Auditory change detection and visual selective attention: association between MMN and N2pc.

While the auditory and visual systems each provide distinct information to our brain, they also work together to process and prioritize input to address ever-changing conditions. Previous studies highlighted the trade-off between auditory change detection and visual selective attention; however, the relationship between them is still unclear. Here, we recorded electroencephalography signals from 106 healthy adults in three experiments. Our findings revealed a positive correlation at the population level between the amplitudes of event-related potential indices associated with auditory change detection (mismatch negativity) and visual selective attention (posterior contralateral N2) when elicited in separate tasks. This correlation persisted even when participants performed a visual task while disregarding simultaneous auditory stimuli. Interestingly, as visual attention demand increased, participants whose posterior contralateral N2 amplitude increased the most exhibited the largest reduction in mismatch negativity, suggesting a within-subject trade-off between the two processes. Taken together, our results suggest an intimate relationship and potential shared mechanism between auditory change detection and visual selective attention. We liken this to a total capacity limit that varies between individuals, which could drive correlated individual differences in auditory change detection and visual selective attention, and also within-subject competition between the two, with task-based modulation of visual attention causing within-participant decrease in auditory change detection sensitivity.

Semantic processing of verbal narratives compared to semantic processing of visual narratives: an ERP study of school-aged children.

There is a misconception that pictures are easy to comprehend, which is problematic in pedagogical practices that include pictures. For example, if a child has difficulties with verbal narration to picture sequences, it may be interpreted as specific to spoken language even though the child may have additional difficulties with comprehension of visual narratives in the form of picture sequences. The purpose of the present study was therefore to increase our understanding of semantic processing in the pictorial domain in relation to semantic processing in the verbal domain, focusing on 9-13 years-old children with typical language development. To this end, we measured electrical brain responses (event related potentials, ERPs) in 17 children to (i) pictures (panels) that were predicted versus unpredicted in sequences of panels that conveyed visual narratives and (ii) words that were predicted versus unpredicted in sentences that conveyed verbal narratives. Results demonstrated similarities as there were no significant difference in the magnitude of the N400 effect across domains. The only difference between domains was the predicted difference in distribution, that is, a more posterior N400 effect in the verbal domain than in the pictorial domain. The study contributes to an increased understanding of the complexity of processing of visual narratives and its shared features with processing of verbal narratives, which should be considered in pedagogical practices.

Age-Specific Effects of Visual Feature Binding.

Temporary binding of visual features enables objects to be stored and maintained in the visual working memory as a singular structure, irrespective of its inherent complexity. Although working memory capacity is reduced in aging, previous behavioral studies suggest that binding is preserved. Using event-related brain potentials (ERPs), we tested whether stimulus encoding is different in younger (N = 26, mean age = 28.5) and older (N = 22; mean age = 67.4) participants in a change detection task. The processing costs of binding were defined by the difference between feature-alone (color or shape) and feature-binding (color-shape) conditions. The behavioral data revealed that discrimination ability was reduced in the feature-binding condition, and that this effect was more attenuated in older participants. A corresponding ERP effect was not found in early components related to visual feature detection and processing (posterior N1 and frontal P2). However, the late positive complex (LPC) was more often expressed in the feature-binding condition, and the increase in amplitude was more pronounced in older participants. The LPC can be related to attentional allocation processes which might support the maintenance of the more complex stimulus representation in the binding task. However, the selective neural overactivation in the encoding phase observed in older participants does not prevent swap errors in the subsequent retrieval phase.

Revisiting the automaticity of reading: Electrophysiological recordings show that stroop words capture spatial attention.

Interference in the Stroop task is reduced when the word and color patch are placed at different locations and is diluted further by the presence of another distractor that is response neutral. Such dilution indicates that reading is not independent of an observer's attentional focus and thus is not a fully automatic process. So where does reading fall on the automaticity continuum? To address this question, we sought to determine whether an irrelevant word that appears abruptly in the field of view invariably draws attention to its location or whether observers can successfully ignore it while identifying a centrally presented target. In two experiments, electrical brain activity was recorded while healthy young adults participated in nonintegrated Stroop tasks. Irrelevant color words appearing randomly to the left or right of a target shape elicited an event-related potential component that reflects the spatial focusing of attention (posterior contralateral N2; N2pc). This N2pc was observed when participants discriminated the color of the target and when they discriminated the shape of the target. These findings demonstrate that color words reflexively capture spatial attention even when their meaning is unrelated to the task at hand. We conclude that although reading is not fully automatic, skilled readers cannot ignore words that appear abruptly in their field of view. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Electrophysiological correlates of self-prioritization

Personally relevant stimuli exert a powerful influence on social cognition. What is not yet fully understood, however, is how early in the processing stream self-relevance influences decisional operations. Here we used a shape-label matching task in conjunction with electroencephalography and computational modeling to explore this issue. A theoretically important pattern of results was observed. First, a standard self-prioritization effect emerged indicating that responses to self-related items were faster and more accurate than responses to other-related stimuli. Second, a hierarchical drift diffusion model analysis revealed that this effect was underpinned by the enhanced uptake of evidence from self-related stimuli. Third, self-other discrimination during matching trials was observed at both early posterior N1 and late centro-parietal P3 components. Fourth, whereas the N1 was associated with the rate of information accumulation during decisional processing, P3 activity was linked with the evidential requirements of response selection. These findings elucidate the electrophysiological correlates of self-prioritization.

Operator State in a Workplace Simulation Modulates Eye-Blink Related EEG Activity.

Evaluating and understanding the cognitive demands of natural activities has been difficult using neurocognitive approaches like mobile EEG. While task-unrelated stimuli are commonly added to a workplace simulation to estimate event-related cognitive processes, using eyeblink activity poses an alternative as it is inherent to human behavior. This study aimed to investigate the eye blink event-related EEG activity of fourteen subjects while working in a power-plant operator simulation - actively operating (active condition) or observing (passive condition) a real-world steam engine. The changes in event-related potentials, event-related spectral perturbations, and functional connectivity under both conditions were analyzed. Our results indicated several cognitive changes in relation to task manipulation. Posterior N1 and P3 amplitudes revealed alterations associated with task complexity, with increased N1 and P3 amplitudes for the active condition, indicating greater cognitive effort than the passive condition. Increased frontal theta power and suppressed parietal alpha power were observed during the active condition reflecting high cognitive engagement. Additionally, higher theta connectivity was seen in fronto-parieto-centro-temporo-occipital regions as task demands increased, showing increased communication between brain regions. All of these results suggest using eye blink-related EEG activity to acquire a comprehensive understanding of neuro-cognitive processing while working in realistic environments.

Specificity of visual event-related potentials to subthreshold presentation of erotic pictures in pedophilia

To study visual event-related potentials (ERPs) associated with presentation of erotic pictures in backward masking condition in order to investigate perception, attention and information processing underlying the initiation and maintenance of abnormal sexual behavior in pedophilia. Participants (58 males committed sexual offenses against children) were divided into the pedophilia group (n=38) and the control group without disorders of sexual preference (n=20). Three types of stimuli were used: neutral pictures of nature (S1), adult heterosexual erotic pictures (S2) and erotic pictures with children (S3). Posterior N1 (N140) and anterior N1 (N120) and P3 (P320) ERP components were included in analysis. In both groups, the perception of erotic stimuli was accompanied by a significant increase in the amplitude and prolongation of the latency of the N140 and P320 components (p<0.001). N140 changes were characterized by right-hemispheric bias in both groups, however, asymmetry was observed for amplitude in the control group, and for latency - in the pedophilia group; besides, reactivity to S3 stimuli was weaker than to S2 ones in the pedophilia group. N120 amplitude was elevated significantly in response to S2 stimuli in the control group, and no changes were found in the pedophilia group. Between-group differences were revealed for early negative components N140 and N120, which parameters were entered as predictors into classification model based on discriminant analysis. The obtained accuracy of model was 87.23%. The specificity of neurophysiological reactions to erotic pictures in pedophilic patients corroborates the concept of disease as general neurodevelopmental disorder.

Working memory biases early object discrimination and parietal activity during attentional selection.

The contents of working memory (WM) guide visual attention, but the neural mechanisms underlying WM biases remains unclear. Here, we used simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) approaches to characterize the timing and location of the neural response underlying WM guidance during a visual search task. Behaviorally, we observed faster search performance when the WM contents matching targets (valid) compared to when WM contents did not reappear (neutral). The EEG data showed similar benefit effects of posterior N1 component, in which targets induced larger N1 amplitudes in the valid condition than in the neutral condition. Interestingly, the fMRI activation in left supramarginal gyrus (SMG)/inferior parietal lobule (IPL) and bilateral occipital cortex was lower in the valid compared to neutral conditions. Importantly, the magnitude of the increased N1 activity and the decreased fMRI activity in the left SMG/IPL predicted the extent of search improvement at an individual subject level. These results suggest that information held in WM enhances early object discrimination during attentional selection, and the left SMG/IPL may be a critical region in mediating goal-directed processing under WM biases in human visual attention.

Context dissociations of the FN400 and N400 are evidence for recognition based on relative or absolute familiarity

Fluency, the ease of processing, can increase familiarity and the ability to recognize previously encountered information. Mixing or blocking the pre-experimental familiarity of test probes alters the pattern of recognition Event-Related Potentials (ERPs) for picture stimuli (Bruett & Leynes, 2015). The present study tested this idea further by mixing or blocking pre-experimental familiarity of word stimuli. A test with only pre-experimentally familiar words (Experiment 1) elicited the prototypical mid-frontal FN400 old/new ERP difference, which is a correlate of familiarity. However, tests with a mix of pre-experimentally familiar and unfamiliar words (Experiment 2) elicited posterior N400 old/new differences. Based on the Unexpected Fluency Attribution model (Mecklinger & Bader, 2020), this pattern of results suggests that pre-experimental fluency can influence the use of relative (changes from recent exposure) or absolute (baseline levels accrued from experience) familiarity to make a recognition judgment.

Attention to affect 2.0: Multiple effects of emotion and attention on event-related potentials of visual word processing in a valence-detection task.

Here we continue recent work on the specific mental processes engaged in a valence-detection task. Fifty-seven participants responded to one predefined target level of valence (negative, neutral, or positive), and ignored the remaining two levels. This enables more precise fine-tuning of neuronal pathways, compared to valence categorization where attention is divided between different levels of valence. Our group recently used valence detection with emotional words. Posterior P1 and N170 effects in the event-related potential (ERP) supported the idea of valent word forms that can be tuned by selective attention to valence. Here we report findings on three distinct posterior N2 components, P300, N400, and the late positive potential (LPP). Target but not nontarget words showed an arousal effect (emotional > neutral) on left-side early posterior negativity (180-280 ms). In contrast, an arousal effect on a sharp N2 deflection in left-minus-right difference ERPs (230-270 ms), suggesting facilitation of lexical access for emotional words, was independent of target status. This also applied to increased medial parieto-occipital N2 (260-300 ms) specific to negative words, indicating attentional capture. Medial-central N400 was specifically enhanced for negative nontarget words, further supporting attentional capture. The typical LPP arousal effect was observed, being stronger and more left-lateralized in target words. An exploratory finding concerned a broad component-overarching ERP valence effect (250-650 ms). Independent of target status, ERPs were more positive for positive than negative words. Combined with our previous results, data suggest multiple loci of emotion-attention interactions in valence detection.

Diversion of Attention Leads to Conflict between Concurrently Attended Stimuli, Not Delayed Orienting to the Object of Interest.

The control processes that guide attention to a visual-search target can result in the selection of an irrelevant object with similar features (a distractor). Once attention is captured by such a distractor, search for a subsequent target is momentarily impaired if the two stimuli appear at different locations. The textbook explanation for this impairment is based on the notion of an indivisible focus of attention that moves to the distractor, illuminates a nontarget that subsequently appears at that location, and then moves to the target once the nontarget is rejected. Here, we show that such delayed orienting to the target does not underlie the behavioral cost of distraction. Observers identified a color-defined target appearing within the second of two stimulus arrays. The first array contained irrelevant items, including one that shared the target's color. ERPs were examined to test two predictions stemming from the textbook serial-orienting hypothesis. Namely, when the target and distractor appear at different locations, (1) the target should elicit delayed selection activity relative to same-location trials, and (2) the nontarget search item appearing at the distractor location should elicit selection activity that precedes selection activity tied to the target. Here, the posterior contralateral N2 component was used to track selection of each of these search-array items and the previous distractor. The results supported neither prediction above, thereby disconfirming the serial-orienting hypothesis. Overall, the results show that the behavioral costs of distraction are caused by perceptual and postperceptual competition between concurrently attended target and nontarget stimuli.

Dynamic inhibitory control prevents salience-driven capture of visual attention.

The salience-driven selection theory is comprised of three main tenets: (a) the most salient stimulus within a monitored region of the visual field captures attention, (b) the only way to prevent salience-driven distraction is by narrowly focusing attention elsewhere, and (c) all other goal-driven processes are possible only after the most salient item has been attended. Evidence for and against this theory has been provided from two experimental paradigms. Here, event-related potentials (ERPs) recorded in a novel Go/No-Go paradigm disconfirmed all three of tenets of the theory. Participants were instructed to search cyan-item displays for a salient orientation singleton (Go trials) and to ignore randomly intermixed yellow-item displays that could also contain an orientation singleton (No-Go trials). ERP components associated with attentional orienting (posterior contralateral N2; N2pc), distractor suppression (distractor positivity; PD), and stimulus relevance (P2a) were isolated to test predictions stemming from the salience-driven selection theory. On No-Go trials, the salient oddball elicited a PD rather than an N2pc, indicating that it was suppressed, not attended. Moreover, a P2a emerged before the N2pc on Go trials, demonstrating that observers first evaluated the global color of each display and then decided to search for the oddball (Go trials) or to ignore it (No-Go trials). We conclude that goal-driven processes can lead to the prevention of salience-driven attention capture by salient visual objects within the attentional window. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Atypical Developmental Trajectories of Early Perception Among School-Age Children With Attention Deficit Hyperactivity Disorder During a Visual Search Task.

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by cognitive deficits associated with attention. Prior studies have revealed the potential impact of ADHD on basic perception and cognitive ability in patients with ADHD. In this study, bilateral posterior P1 and N1 were measured in 122 Chinese children aged 7-12 years (64 with ADHD) to investigate the developmental characteristics of early perception during visual processing in school-age children with ADHD. For children with ADHD, a larger P1 activity with an atypical developmental pattern was evoked and observed for the visual search performance. These findings offer new insights into the mechanisms of cognitive developmental deficits and intervention techniques in children with ADHD.

The Neural Blending of Words and Movement: Event-Related Potential Signatures of Semantic and Action Processes during Motor-Language Coupling.

Behavioral embodied research shows that words evoking limb-specific meanings can affect responses performed with the corresponding body part. However, no study has explored this phenomenon's neural dynamics under implicit processing conditions, let alone by disentangling its conceptual and motoric stages. Here, we examined whether the blending of hand actions and manual action verbs, relative to nonmanual action verbs and nonaction verbs, modulates electrophysiological markers of semantic integration (N400) and motor-related cortical potentials during a lexical decision task. Relative to both other categories, manual action verbs involved reduced posterior N400 amplitude and greater modulations of frontal motor-related cortical potentials. Such effects overlapped in a window of ∼380-440 msec after word presentation and ∼180 msec before response execution, revealing the possible time span in which both semantic and action-related stages reach maximal convergence. These results allow refining current models of motor-language coupling while affording new insights on embodied dynamics at large.

Priming of grasp affordance in an ambiguous object: evidence from ERPs, source localization, and motion tracking

Object affordance refers to possibilities to interact with the objects in our environment, such as grasping. Previous research shows that objects that afford an action activate the motor system and attract attention, for example they elicit an enhanced frontal negativity and posterior P1 in the event-related potential. An effect on posterior N1 is discussed. However, previous findings might have resulted from physical differences between affording and non-affording stimuli, rather than affordance per se. Here we replicated the frontal negativity and posterior P1 effects and further explored the posterior N1 in affordance processing under constant visual input. An ambiguous target was primed either with an affording (pencils) or non-affording (trees) context. Although physically always identical, the target elicited an enhanced frontal negativity and posterior P1 in the pencil prime condition. Posterior N1 was reduced and grip aperture in a grasping task was smaller in the affording context. Source localization revealed stronger activation in occipital and parietal regions for targets in pencil versus tree prime trials. Thus, we successfully show that an ambiguous object primed with an affording context is processed differently than when primed with a non-affording context. This could be related to the ambiguous object acquiring a potential for action through priming.

Electrophysiological Correlates of Basic and Higher Order Cognitive and Affective Theory of Mind Processing in Emerging and Early Adulthood-An Explorative Event-Related Potentials Study to Investigate First-, Second-, and Third-Order Theory of Mind Processing Based on Visual Cues.

Attributing mental states to others in social interactions [Theory of Mind (ToM)] often depends on visual social cues like eye gaze or mimic. This study presents an event-related potentials task (Brainy-ERP) that was developed in order to investigate the electrophysiological correlates of first-, second-, and third-order cognitive and affective ToM processing. The task was based on social visual cues and involved electroencephalographic event-related potential (ERP) analyses and exact low-resolution brain electromagnetic tomography analyses (eLORETA) source localization analyses. Results showed that in cognitive and affective conditions, first-order trials elicited greater Anterior P2 (180–370 ms) amplitudes. In the cognitive condition, third-order trials elicited greatest amplitudes in the broadly distributed early negative slow wave (eNSW, 260–470 ms) and the late NSW (LNSW, 460–1,000 ms). In the affective condition, third-order and second-order trials elicited greatest amplitudes in a broadly distributed NSW (250–1,000 ms). Regarding affective trials in the NSW time span, statistical significant differences and trends were shown regarding activation of underlying brain regions. Third-order trials elicited greatest activation in a number of regions typically associated with the ToM network, especially the posterior cingulate cortex (PCC), cuneus, and temporoparietal junction (TPJ). Furthermore, ToM low performers (participants with high accuracy but longer reaction times) showed by trend smaller Posterior N1 and significantly smaller eNSW amplitudes compared to average and high performers. This study offers new insights into electrophysiological correlates of basic and higher order cognitive and affective ToM processing and its precise time course.

A novel experimental paradigm with improved ecological validity reveals robust action-associated enhancement of the N1 visual event-related potential in healthy adults

The association between an action and its sensory consequence has been linked to our sense of agency (SoA). While ecological validity is crucial in investigating such a complex phenomenon, previous paradigms focusing on the cortical analysis of movement-related images used simplified experimental protocols. Here, we examined the influence of action-associated predictive processes on visual event-related potentials (ERPs) in a paradigm that models everyday actions more precisely, using a commercial gesture control device, ecological stimuli depicting a human hand and a behavioural training to reinforce the sense of control over action outcomes. We assessed whether a more natural setup would result in robust ERP modifications following self-initiated movements relative to passive viewing of the same images. We found no compelling evidence for amplitude modulation for the early occipital C1 and P1 components. Crucially, we observed strong action-associated amplitude enhancement for the posterior N1, an effect that was not present in our previous study that relied on conventional button-presses. We propose that the N1 effect in our ecologically more valid paradigm can either reflect stronger attentional amplification of domain-specific visual processes following self-initiated actions, or indicate that sensory predictions in the visual N1 latency range manifest in larger (rather than reduced) ERPs. Overall, our novel approach utilizing a gesture-control device can be a potent tool for investigating the behavioural and neural manifestations of SoA in the visual modality.

Categorization of emotional faces in schizophrenia patients: An ERP study

Schizophrenia patients often show deficits in facial emotion recognition, which contributes to their poor social functioning. The present study investigated the time course of categorization of emotional faces in schizophrenia patients by recording and analyzing ERPs elicited by emotional faces. Behavioral data show that in comparison with controls, schizophrenia patients categorized emotional faces more slowly with decreased accuracy and did not show evident positive classification advantage. The ERP data showed that the N170 decreased in schizophrenia patients although it was not modulated by facial emotions. In comparison with controls, schizophrenia patients exhibited the lack of frontal and posterior N2 components and decreased P3 component, without P3 modulation of emotional faces. These data provide new evidence for the dysfunction of processing emotional faces in schizophrenia patients.