Poster Form Research Articles

DEVELOPMENT OF MICROLEARNING OBJECT ON HIGH SCHOOL GEOMETRY MATERIALS

The implementation of this research has the aim of seeing of microlearning material for high school geometry material, to see the location of the microlearning object for high school geometry material. Media Microlearning Object developed using Podcast, Power Point, Poster and Google Form applications that are loaded on the Google site. This study uses the ADDIE development model (Analysis, Design, Develop, Implement, and Evaluate). This research was conducted at SMA Negeri 1 Stabat. The subjects in this study were students of class XI SMA Negeri 1 Stabat and the object of the research was microlearning objects on geometry material. The results of this study obtained a valid and effective object Microlearning product. Where in the aspect of the relevance of the material obtained an average of 3.5 which is included in the valid category and in the media aspect an average of 3.45 is obtained which is included in the valid category. Furthermore, the teacher's response obtained an average of 4.1 and from the student response data obtained a value of 88.5%. This means that the learning media for microlearning objects in high school geometry material gets a positive response. and is said to be effective.

The Third China International Synthetic Aperture Radar Symposium [Conference Reports

From 2 to 4 November 2022, the third China International Synthetic Aperture Radar (SAR) Symposium (CISS), sponsored by the Shanghai Institute of Satellite Engineering, was successfully held at the Jinjiang Metropolo Hotel Minhang, Shanghai. The CISS is an international academic conference with extensive authority, knowledge, and interaction. The symposium aims to build a high-level and international academic communication platform for scholars and researchers in the SAR field, lead the direction of technology development in the SAR field, and promote technology innovation in related fields. CISS 2022 was technically cosponsored by IEEE and the IEEE Geoscience and Remote Sensing Society (GRSS). More than 180 invited experts and scholars from China, Germany, New Zealand, Poland, and other countries assembled to discuss the latest developments and achievements in SAR-related areas, including hardware systems, processing techniques, advanced applications, and so on. CISS 2022 was held online and offline, and more than 150 participants attended offline live events. Nine experts ( <xref ref-type="fig" rid="fig1" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Figure 1</xref> ) gave keynotes during the opening ceremony. During the conference, 72 researchers presented their work in oral form, while 94 reports were presented in poster form.

Emerging trends and hot spots on electrical impedance tomography extrapulmonary applications

ObjectiveElectrical impedance tomography (EIT) develops rapidly in technology and applications. Nowadays EIT is used in multiple clinical and experimental scenarios including pulmonary, brain, and tissue monitoring, etc. The present study explores the research trends and hotspots on EIT extrapulmonary application research by bibliometrics analysis. ApproachPublications on EIT extrapulmonary applications between 1987 and 2021 were retrieved from the Web of Science Core Collection database. For precise screening, search strategy “electrical impedance tomography” plus “hemodynamic” or “brain” or “nerve” or “cancer” or “venous” or “vessel” or “tumor” or “veterinary” or “tissue” or “cell” or “wearable” or “application” and excluding “lung”, “ventilation” “respiratory”, “pulmonary”, “algorithm”, “current”, “voltage” or “electrode” were used. CiteSpace and VOSviewer were used to analyze the publication features, collaboration, keywords co-occurrence, and co-cited reference. Main resultsA total of 506 articles were finally identified. The global publication numbers on extrapulmonary applications gradually increased yearly in the past 30 years. The US, UK, and China contributed most three publications concerning EIT extrapulmonary applications. “tissues”, “conductivity”, “model” were research hotspots, and “cutaneous melanoma”, “microstructure”, “diagnosis” were recent topics (Portions of this research have previously been presented in poster form). SignificanceOverall, EIT extrapulmonary applications bibliometrics analysis provides a unique insight into research focus, current trends, and future directions.

Treatment patterns and health care costs among patients with psoriatic arthritis treated with biologic or targeted synthetic disease-modifying antirheumatic drugs.

BACKGROUND: Biologic and targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies are used in management of psoriatic arthritis (PsA). Although previous studies have demonstrated that rates of adherence, persistence, discontinuation, and switching, as well as health care costs, are variable among treatments, limited published data exist on more recently approved therapies. OBJECTIVE: To describe adherence, persistence, discontinuation, reinitiation, switching, dosing patterns, and health care costs among PsA patients treated with biologics and tsDMARDs. METHODS: This was a real-world, retrospective administrative claims study. Adult PsA patients with at least 1 claim for an approved PsA biologic (adalimumab, certolizumab, etanercept, golimumab, infliximab, secukinumab, or ustekinumab) or tsDMARD (apremilast or tofacitinib) between January 1, 2015, and June 30, 2019, were selected from the IBM MarketScan administrative claims databases. The first claim for one of the study treatments determined the index date and drug cohort. Patients were required to be continuously enrolled in their health plans for 12 months before and after the index date and to have at least 1 claim with a diagnosis of PsA in the 12 months before or on the index date. Adherence (measured by proportion of days covered [PDC] and medication possession ratio [MPR]), persistence (< 60-day gap in treatment), discontinuation (> 90-day gap), reinitiation of index drug, switching, and dosing patterns for each index drug were assessed during the 12-month follow-up period. Health care costs were reported per patient per month (PPPM) during the 12-month follow-up and assessed after adjusting PsA treatment costs by the Institute for Clinical and Economic Review discount factors to account for discounts and rebates not usually reflected in claims data and by adherence. RESULTS: Overall, 6,674 patients met the selection criteria. The top 3 index drugs were adalimumab (37%), apremilast (26%), and etanercept (18%). Over 12 months of follow-up, 31%-59% of patients remained persistent on the index drug, whereas 35%-56% discontinued, 13%-29% switched to a different biologic or tsDMARD, and 3%-15% reinitiated the index therapy, depending on the index drug. The mean PDC ranged from 0.51 to 0.69 during the 12-month follow-up and 0.80 to 0.93 during the follow-up period before discontinuation. Dose values were largely consistent with prescribing information, with the exception of secukinumab. Index drug costs PPPM ranged from $2,361 (apremilast) to $6,528 for ustekinumab after adjustment for discounts and adherence. CONCLUSIONS: Results from this real-world analysis suggest that there is substantial variability in persistence, discontinuation, adherence, reinitiating, and switching patterns among the different biologic and tsDMARD treatment options for PsA patients. In addition, this study provides real-world cost data for biologics and tsDMARDs among patients with PsA. DISCLOSURES: This study was funded by Eli Lilly Inc., which participated in analysis and interpretation of data, drafting, reviewing, and approving the publication. All authors contributed to the development of the publication and maintained control over the final content. Murage, Malatestinic, Zhu, Atiya, Kern, Stenger, and Sprabery are employees and stockholders of Eli Lilly Inc. Princic and Park are employed by IBM Watson Health, which received funding from Eli Lilly Inc. to conduct this study. Ogdie has received consulting fees from Amgen, AbbVie, Bristol-Myers Squibb, Celgene, Corrona, Janssen, Lilly, Novartis, and Pfizer and has also received grant support from Pfizer, Novartis, and Amgen. Portions of these data have been presented in poster form at the virtual International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 2020 and Congress of Clinical Rheumatology (CCR) West 2020 conferences.

The publication rate of presented abstracts at a congress and determining its publication factor

Background/Aim: Congresses, scientific fairs on an academic platform, are held in numerous disciplines all over the world and bring physicians together. Through these congresses, the physicians can follow the latest developments in their profession and present their work. Many researchers first present their work in a congress, then update their work in the light of the feedbacks and publish them in a peer-reviewed journal. Although many oral and poster presentations are made in scientific congresses, a small portion are finally published in a peer-reviewed journal. This may be because the effort spent in preparing an abstract is much less than that spent during the preparation of an entire manuscript. However, the publication of a presentation in a peer-reviewed journal is a gold standard factor showing the quality of research and that it is worthy of publication. More detailed congress abstract evaluation criteria and their proximity to the procedures involved during the journal acceptance stage will likely enhance the publication rate. The purpose of this study was to perform a detailed evaluation of presentations at congresses held by the European Society of Trauma and Emergency Surgery (ESTES) in 2013, 2014, 2015 and determine their rates of publication in peer-reviewed journals. Methods: The booklets for three consecutive annual ESTES congresses (2013, 2014, 2015) containing presented papers were accessed online. All oral and poster presentations were analyzed, and published studies in peer-reviewed journals that are indexed in Google Scholar database until 2019 were identified. These published studies were then analyzed and used to determine the Publication Factor for Congress (PFC) for these congresses. Results: The total number of presentations at ESTES congresses in 2013-2015 was 1746, of which 878 were oral (50.2%) and 868 (49.8%) were in poster form. 450 (25.7%) of these were subsequently published in peer-reviewed journals that are indexed in Google Scholar database. 148 of the published papers (32.9%) were based on poster presentations, and 302 (67.1%) were from oral presentations. Conclusion: The publication rate of oral and poster presentations presented at the 2013-2015 ESTES congresses from the date of the congress to 2019 was 25.7%. Oral presentations were published more than poster presentations. It suggests that the papers with high publication potential have a high tendency to be presented as oral presentations by the authors. Determination of publication rates and publication factor for a congress at specific intervals may increase the motivation of authors at the participation and submission stages and strengthen the brand value.

Health care resource utilization and cost of severe hypoglycemia treatment in insulin-treated patients with diabetes in the United States.

BACKGROUND: Hypoglycemia is a major limiting factor in achieving glycemic control in persons with diabetes. In some instances, recovery from a severe hypoglycemia event may require health care resource utilization (HCRU), including the use of emergency medical services (EMS), visits to the emergency department (ED), and inpatient hospitalization. OBJECTIVES: To (a) describe the profiles of patients who experience severe hypoglycemic events and (b) characterize HCRU and the associated cost related to severe hypoglycemia treatment. METHODS: This retrospective, observational cohort study used administrative claims data from IBM MarketScan Research Databases. The study examined a cohort of subjects who experienced severe hypoglycemic events that involved HCRU during the 1-year index period. Baseline patient demographic data were collected according to patient profiles, such as payer type, type of diabetes, age, and type of insulin. HCRU and the associated cost data categorized by the patient profiles and care progression scenarios were described. RESULTS: 9,563 patients from the IBM MarketScan Research Databases experienced a severe hypoglycemic event during the index period and were included in the study; approximately 75% of those patients did not experience a severe hypoglycemic event in the previous year. Of the 9,563 patients in the cohort, the largest patient profile (n = 1,767, 18.5%) consisted of those who were on Medicaid, had type 2 diabetes, and used basal/bolus or premixed-only insulins. Overall, more than 90% of the index severe hypoglycemic events involved visits to the ED. EMS claims in the 24 hours before the ED visit were found for half of the severe hypoglycemic events (51.5%). CONCLUSIONS: Differences in HCRU and the associated costs for the treatment of severe hypoglycemia were observed among patients based on insurance, diabetes, and insulin types. Clinicians need to be aware of these differences. Optimizing treatment of severe hypoglycemia, specifically EMS care, and examining patient profiles to develop targeted interventions could potentially provide benefits to patients and reduce cost and resource utilization. DISCLOSURES: This study was funded by Eli Lilly and Company. All authors are employees and shareholders of Eli Lilly and Company. The data presented here have been presented in poster form at AMCP Nexus 2020 Virtual, October 19-23, 2020; ADCES Virtual Conference 2020, August 13-16, 2020; and Virtual ISPOR 2020, May 18-20, 2020.

Gene Annotation in High Schools: Successful Student Pipeline and Teacher Professional Development in Bioscience Using GENI-ACT.

Knowledge of genomics is an essential component of science for high school student health literacy. However, few high school teachers have received genomics training or any guidance on how to teach the subject to their students. This project explored the impact of a genomics and bioinformatics research pipeline for high school teachers and students using an introduction to genome annotation research as the catalyst. The Western New York-based project had three major components: (1) a summer teacher professional development workshop to introduce genome annotation research, (2) teacher-guided student genome annotation group projects during the school year, (3) with an end of the academic year capstone symposium to showcase student work in a poster session. Both teachers and students performed manual gene annotations using an online annotation toolkit known as Genomics Education National Initiative-Annotation Collaboration Toolkit (GENI-ACT), originally developed for use in a college undergraduate teaching environment. During the school year, students were asked to evaluate the data they had collected, formulate a hypothesis about the correctness of the computer pipeline annotation, and present the data to support their conclusions in poster form at the symposium. Evaluation of the project documented increased content knowledge in basic genomics and bioinformatics as well as increased confidence in using tools and the scientific process using GENI-ACT, thus demonstrating that high school students are capable of using the same tools as scientists to conduct a real-world research task.

Preface to 2nd National Conference on Frontiers in Modern Physics :

After observing the immense success of 1st National Conference on Frontiers in Modern Physics (NCFMP) in 2018, and the interest of the participants, the organisers decided to organise the 2nd version of the conference with more pace and versatility. 2nd National Conference on Frontiers in Modern Physics (2nd NCFMP) was held on 6th-7th February, 2020 in the City of Joy – Kolkata, India. The sprawling green campus of Adamas University was he venue of the conference. The University was established in 2014 and the Department of Physics of the University started its first batch in the year 2015. In this span of time, the Department of Physics has achieved prestigious milestones in terms of research, project, patents, device developments, conference and other teaching-learning & academic activities. 2nd NCFMP was attend by eminent Professors & dignitaries from various National organisations of repute: Prof. Pushan Ayuub, TIFR, MumbaiProf. Soumitra Sengupta, IACS, Kolkata, Prof. Indrani Bose, Senior Professor, Bose Institute, Prof. Jayanta Kumar Bhattacharya, Distinguished Visiting Professor, IACS, Kolkata Ex Director, HRI, Allahabad, Prof. Ananda Dasgupta, IISER, Kolkata, Dr. Debashri Ghosh, Senior Scientist, CGCRI, Kolkata, Prof. Tejinder Pal Singh, TIFR, Mumbai are a few of the eminent keynote speakers.The proceedings of 2nd NCFMP span over 7 topical tracks, that include: Condensed matter Physics, Applied Electronics, Medical Physics, High Energy Physics & Field theory, Plasma Physics, Nuclear physics and Astrophysics. A large number of research papers were contributed by researchers from various parts of India and amongst those 56 research papers were selected for presentation (Acceptance rate: 55%) in the Conference in oral and poster form. From the 56 research papers presented in the conference; based on the merit, contents, novelty and writing the reviewers selected 26 good standard work for publication in form of full paper in indexed proceedings. Efforts are taken by the learned reviewers, to improve the quality of the papers by providing constructive critical comments, improvements and correction to the authors, are gratefully acknowledged. We are really grateful to the International/ National advisory committee, keynote speakers, session chairs, organising committee members, student volunteers and administrative assistance of the management section of University, including accounts section, digital media and publication house. Also we are thankful to all the authors for contributing a large number of papers in the conference, because of which the conference became a story of success. It was the quality of their presentations and their passion to communicate with the other participants that really make this conference series a great success.Last but not the least, we are really thankful to IOP publishing house for supporting us in every step of our journey towards success. Their support was not only the strength but also an inspiration for the NCFMP organisers. Edited by: Dr. Moumita Mukherjee, Associate Professor, Dept. of Physics, Adamas UniversityDr. Moumita Dey, Assistant Professor & HOD - Dept. of Physics, Adamas University

67 Reducing Delays to Operative Management of Anti-Coagulated Patients With Hip Fractures

Abstract Introduction In the UK, the gold-standard treatment of a hip fracture is surgical fixation within 36 hours. Reduced delay to surgery has been shown to minimise the risk of complications. Locally, frequent delays to surgery were observed in patients taking long-term anticoagulation. There are no national guidelines regarding anticoagulation reversal and surgery timing in patients with hip fractures, and doctors are often unfamiliar with increasingly prevalent Direct Oral Anti-coagulants (DOACs). This quality improvement project aimed to reduce delays to surgery in anti-coagulated patients with hip fractures. Methods A guideline was formulated following literature review and consultation with a Consultant Ortho-geriatrician, Orthopaedic Surgeon and Haematologist. Retrospective casenote audit was conducted including 3-month period before and after implementation. The new guideline was disseminated in poster form. Due to the observation that delays in receiving INR results resulted in reversal delay, patient’s on warfarin were recommended to receive 5 mg IV Vitamin K prior to receiving INR results. The INR was rechecked after 6 hours, and if less than 1.6, surgery could proceed. Those on DOACs could undergo surgery 24 hours after the last dose providing eGFR &amp;gt;30, and after 48 hours if eGFR &amp;lt;30. Exclusions were those anti-coagulated for metallic heart valves or recent venous thromboembolism. Results In the 3 months prior to guideline implementation, 71 patients had a hip fracture; 15 were anti-coagulated. Of these, 8 patients were delayed due to their anticoagulation. Repeat audit after implementation, included 46 patients with a hip fracture over the 3-month period; 7 were anti-coagulated. None were delayed due to anticoagulation (p &amp;lt; 0.05). Conclusions This improvement project describes formulation of a simple protocol with evidence from the literature and local expert opinion in order to reduce unnecessary delays in anti-coagulated patients with hip fractures.

Economics of using telehospice to supplement hospice care in rural areas.

11535 Background: Hospice care in rural areas is often characterized by provider shortages and vast geographical service areas to cover, making access to quality end-of-life care challenging. Telehospice, the utilization of interactive video (ITV) technology to provide health services over a distance for hospice patients, has been proposed as a solution to address access issues. In 2017, the University of Kansas Medical Center (Kansas City, Kansas) partnered with Hospice Services, Inc. (HSI) (Phillipsburg, Kansas) to augment traditional, in-person hospice care with hospice care delivered via mobile tablets.This work examines the costs of Telehospice when compared with the costs of in-person hospice services. Methods: Detailed administrative data from July 1, 2018 to December 31, 2018 was analyzed to estimate the costs of service after Telehospice use was inculcated into routine practice. Results: Hospice Services, Inc., which averages a daily census of 34 patients, conducted 257 calls, averaging 28 hours a month. The average time for a Telehospice call was 21 and 18 minutes for nursing and medical director calls, respectively. Through various hospice functions, including administrative, patient, and non-patient related connections, HSI saved over $115,000 in staff travel time and mileage reimbursement. Administratively, by hosting their weekly 14-member interdisciplinary meeting via ITV, HSI saved $29,869 of staff travel time and mileage reimbursement. Conclusions: Our estimates indicate substantial cost saving potential with the use of Telehospice services. Further research is needed to assess the effects of Telehospice utilization on the experiences and subsequent cost of hospice care. Additional cost data specifics will be presented in poster form. [Table: see text]

Meta-analysis of intracavitary electrocardiogram guidance for peripherally inserted central catheter placement.

Recently, intracavitary electrocardiogram technology has been applied to peripherally inserted central catheter placement and demonstrates many potential advantages. However, the tip positioning accuracy of intracavitary electrocardiogram technology compared to conventional X-ray method is unknown. We did a meta-analysis to compare the tip positioning accuracy between intracavitary electrocardiogram technology and conventional X-ray method. We searched several databases, including Cochrane Library, PubMed, Web of science, and Embase. Additional studies were identified through hand searches of bibliographies and Internet searches. All human studies published in full text, abstract, or poster form were eligible for inclusion. Search terms included peripherally inserted central catheter, PICC, intracavitary electrocardiogram, IC-ECG, EKG, ECG, and catheter tip location. Only randomized controlled trials of using intracavitary electrocardiogram technology versus X-ray method for peripherally inserted central catheter placement were included. All studies included adult patients aged at least 18 years. Independent extraction of articles by two authors using predefined data fields, including study quality indicators. Of the 178 citations identified, 5 studies that included 1672 patients met the eligibility criteria. It was found that statistical heterogeneity existed among the various studies (I2 = 16%, p < 0.00001); therefore, the fixed effect model was used in the meta-analysis (p < 0.05). The meta-analysis compared the tip positioning accuracy between intracavitary electrocardiogram technology and X-ray method and showed that intracavitary electrocardiogram technology had a better positioning accuracy (odds ratio: 2.88, 95% confidence interval: 2.15-3.87, p < 0.0001). Only five randomized trial met inclusion criteria, and the lack of an incomplete search led to the publication bias seen in these results. The intracavitary electrocardiogram method had a more favorable positioning accuracy versus traditional X-ray method for peripherally inserted central catheter placement in adult patients. The intracavitary electrocardiogram can be a promising technique to guide tip positioning of peripherally inserted central catheter.

International Investigative Dermatology 2018 Meeting: Promoting Global Skin Biology and Skin Disease Research

International Investigative Dermatology 2018 Meeting: Promoting Global Skin Biology and Skin Disease Research

Measurement of R290 leakage with laser doppler anemometry.

Paper published in poster form during the conference. This paper describes the experience made with the measurement of the velocity field of a plume of leaking R290 into an air-filled space with Laser Doppler Anemometry. Two different leak sizes were tested with both liquid and vapour refrigerant .

Developing poster based on diversity of Nepenthes in Padat Karya Forest Krayan, North Kalimantan

Nepenthes is a unique carnivores plant that can be found in Padat Karya forest, Krayan at the North Kalimantan. The existence of these plants can be used as a media of learning so that learning activities become more contextual. The aims of this study are 1) to know the diversity of Nepenthes in Padat Karya forest, 2) to determine the feasibility of learning media in the form of poster developed from the results of the Nepenthes diversity research. This research consisted of two stages. The first was research stage which involved inventory, identification, and diversity index determination of Nepenthes. The second stage was development research i.e developing the results gained from the first stage into poster form. The research and development model employed in this study was the modified-Borg and Gall (2006) model. There were five steps conducted, namely (1) need analysis, (2) planning, (3) develop the preliminary form of product, (4) preliminary field testing, and (5) main product revision. The results showed that the diversity index value of Nepenthes was categorized as ‘medium’. In addition, based on the validation and response obtained, the poster developed was feasible to be utilized as a learning media in senior high school.

Reference intervals for the evoked tympanic membrane displacement measurement: a non-invasive measure of intracranial pressure**Portions of this work were presented in poster form at the 16th International Symposium on Intracranial Pressure and Neuromonitoring (Cambridge, Massachusetts, 29 June 2016).

Objective: Evoked tympanic membrane displacement (TMD) is a non-invasive technique for assessing intracranial pressure (ICP). The aim of this study was to define reference intervals (RIs) in the healthy population. Approach: Measurements were made in 154 healthy adults. Results were quantified by Vm, which is the most frequently described TMD measurement. Distributions were determined for sitting and supine posture. Differences between right and left ears were explored using a Wilcoxon signed-rank test. Postural changes were used to assess pressure transfer between the cerebral spinal fluid (CSF) and the perilymph. Main results: The range in which 95% of scores fall is −283 to 722 nl (M = 132 nl) left sitting, −232 to 623 nl (M = 97 nl) right sitting, −543 to 717 nl (M = 37 nl) left supine and −584 to 504 nl (M = −15 nl) right supine. No significant difference was seen between the left and right ears in the sitting position; a significant difference was seen in the supine position. A significant effect of posture was seen for both the left and right ears. Postural changes indicated pressure transfer between the CSF and perilymph more often in the right ear (75.3%) than the left (61.9%). Pressure transfer could not be assumed in either ear for 13.4% of participants. Significance: We present the largest dataset of evoked TMD in healthy individuals and the first set of RIs for Vm. A patient cohort with both invasive ICP and evoked TMD measurements is needed to validate the technique for clinical use.

Geographic Variation in the Quality and Cost of Care for Patients with Rheumatoid Arthritis.

There is considerable push to improve value in health care by simultaneously increasing quality while lowering or containing costs. However, for diseases that are best treated with comparatively expensive treatments, such as rheumatoid arthritis (RA), there could be tension between these aims. In this study, we measured geographic variation in quality, access, and cost for patients with RA, a disease with effective but costly specialty treatments. To assess the geographic differences in the quality, access, and cost of care for patients with RA. Using large claims databases covering the period between 2008 and 2014, we measured quality of care metrics by metropolitan statistical areas (MSAs) for patients with RA. Quality measures included use of disease-modifying antirheumatic drugs (DMARDs) and tuberculosis (TB) screening before initiating biologic DMARD therapy. Access to care measures included measured detection and the share of patients with RA who visited a rheumatologist. Regression models were used to control for differences in patient demographics and health status across MSAs. For the 501,376 patients diagnosed with RA, in the average MSA 64.1% of RA patients received a DMARD, and 29.6% of RA patients initiating a biologic DMARD appropriately received a TB screening. Only 17% (73/430) of MSAs comprised the top 2 Medicare Advantage star ratings for DMARD use. Measured detection was 0.59% (IQR = 0.47%-0.71%; CV = 0.355) on average, and 57.6% (IQR = 48%-69%; CV = 0.341) of RA patients visited a rheumatologist. MSAs with the highest DMARD use spent $26,724 (in 2015 U.S. dollars) annually treating patients with RA, $5,428 more (P < 0.001) than low DMARD-use MSAs, largely because of higher pharmacy cost ($5,090 vs. $7,610, P < 0.001). However, MSAs with higher DMARD use had lower RA-related inpatient cost ($1,890 vs. $2,342, P = 0.024). There were significant geographic variations in the quality of care received by patients with RA, although quality was poor in most areas. Fewer than 1 in 5 MSAs could be considered high quality based on patient DMARD use. Access to specialist care may be an issue, since just over half of patients with RA visited a rheumatologist annually. Efforts to incentivize better quality of care holds promise in terms of unlocking value for patients, but for some diseases, this approach may result in higher costs. The research reported in this manuscript was supported by AbbVie through consulting fees paid to Precision Health Economics (PHE). AbbVie and PHE collaborated to develop the study design and protocol. AbbVie and PHE participated in the interpretation of data, review, and approval of the manuscript. Shafrin and Shim are employed by PHE. Ganguli and Sanchez Gonzalez are employed by AbbVie. Seabury reports consulting fees from PHE. The results from this study were presented in poster form at the Academy of Managed Care Pharmacy's 2015 Annual Meeting and Expo; April 7-10, 2015; San Diego, California, and at the Academy of Managed Care Pharmacy's 2016 Annual Meeting and Expo; April 19-22, 2016; San Francisco, California. Study concept and design were contributed primarily by Shafrin, along with Ganguli and Seabury. Shafrin and Shim took the lead in data collection, and data interpretation was performed by Ganguli, Sanchez Gonzalez, Seabury, and Shafrin. The manuscript was written primarily by Shafrin, along with Shim and Seabury, and revised primarily by Ganguli, along with Sanchez Gonzalez and Seabury.

Editorial for the Special Issue on Neurosciences and Music: Part 2.

It is a great privilege to have been the guest editor for this second special issue on the Neurosciences of Music, following up on the 2012 issue on the same theme. It hardly seems like three years have passed, but even in this relatively short time period, we have witnessed conceptual and methodological developments that represent a significant maturation of our field. The contributions of the present issue affirm the breadth and quality of research being undertaken in the music and neuroscience community. The present issue comprises nine empirical papers from contributors in seven different countries. The contributions span perceptual, cognitive, affective, neurological, and therapeutic aspects of music, using an array of neuroimaging approaches, statistical approaches, and paradigms. Topics include distinguishing between how the brain responds to the cognitive versus affective aspects of music (Ellison, Moisseinen, Fachner, & Brattico, in press), how the reward system of musicians versus nonmusicians differs during continuous naturalistic listening (Alluri et al., in press), the role of the amygdala and orbitofrontal cortex in expectation (Mikutta et al., in press), the distinction between different forms of pathological and nonpathological musical imagery (Hemming & Merrill, in press) and the neural signatures of beat-based versus duration-based timing (De Pretto & James, in press). Sturm's paper focuses on the neural responses evoked during naturalistic ensemble listening, while Nakata looks at how tapping with an adaptive partner impacts pitch processing. Pfeiffer and Sabe (in press) provides a novel music-based assessment for the assessment of cognition after brain injury and, with a timely reflection on the current state of our community, Albusac-Jorge and Gimenez-Rodriguez (in press) provides a bibliometric study of the Neuroscience of Music field. We include a report on a high profile public lecture given by Daniel Levitin. Finally, we include a report on a lecture given by Daniel Levitin, and an announcement about a major new research center, Music in the Brain, in Aarhus, Denmark.As was also the case for the first special issue on this topic, we must acknowledge the critical role of the Mariani Foundation, in cooperation with the New York Academy of Sciences, who continue to provide an international nexus for dissemination and collaboration via their excellent research conferences. Several of the papers in the present issue were first presented in poster form at The Neurosciences and Music V conference, in Dijon, France, following which we announced a call for articles. …

Analysis of full-text publication and publishing predictors of abstracts presented at an Italian public health meeting (2005-2007).

BackgroundIn Public Health, a thorough review of abstract quality evaluations and the publication history of studies presented at scientific meetings has never been conducted. To analyse the long-term outcome of quality abstracts submitted to conferences of Italian Society of Hygiene and Public Health (SItI) from 2005 to 2007, we conducted a second analysis of previously published material aiming to estimate full-text publication rate of high quality abstract presented at Italian public health meetings, and to identify predictors of full-text publication.MethodsThe search was undertaken through scientific databases and search engines and through the web sites of the major Italian journals of Public Health. For each publication confirmed as a full text paper, the journal name, impact factor, year of publication, gender of the first author, type of study design, characteristics of the results and sample size were collected.ResultsThe overall publication rate of the abstracts presented is 23.5 %; most of the papers were published in Public Health journals (average impact factor: 3.007). Non universitary affiliation had resulted in a lower probability of publication, while some of the Conference topics had predisposed the studies to an increased likelihood of publication as well as poster form presentation.ConclusionsThe method presented in this study provides a good framework for the evaluation of the scientific evidence. The findings achieved should be taken into consideration by the Scientific Societies during the contributions selection phase, with the aim of achieving a continuous improvement of work quality. In the future, it would be interesting to survey the abstract authors to identify reasons for unpublished data.

Rethinking poster presentations at large-scale scientific meetings – is it time for the format to evolve?

Rethinking poster presentations at large-scale scientific meetings – is it time for the format to evolve?

Schizophrenia relapse and the clinical usefulness of once-monthly aripiprazole depot injection.

Improving medication adherence is critical to improving outcomes in patients with schizophrenia. A long-acting injectable (depot) antipsychotic is one of the most effective methods for improving treatment adherence and decreasing rehospitalization rates in patients with schizophrenia. Until recently, only three second-generation antipsychotics were available in a long-acting injectable formulation (risperidone, paliperidone, and olanzapine). In this respect, the emergence of long-acting aripiprazole injection (ALAI), approved by the US Food and Drug Administration for the treatment of schizophrenia in 2013, is timely. ALAI is a lyophilized powder of aripiprazole, and the aripiprazole molecule is unmodified. The initial and target dosage of ALAI is 400 mg once monthly, but it could be reduced to 300 mg if adverse reactions occur with 400 mg. When first administering ALAI, it is recommended to continue treatment with oral aripiprazole (10–20 mg/day) or another oral antipsychotic for 2 weeks in order to maintain therapeutic antipsychotic concentrations. The primary clearance route for ALAI is hepatic, ie, cytochrome P450 (CYP)2D6 and CYP3A4, so dose adjustment is required in poor CYP2D6 metabolizers. The efficacy of ALAI was demonstrated in three studies. A randomized controlled trial that formed the basis for approval of ALAI in the treatment of schizophrenia showed that ALAI significantly delayed time to impending relapse when compared with placebo (P<0.0001, log-rank test). An open-label, mirror study demonstrated that total psychiatric hospitalization rates were significantly lower after switching from oral antipsychotics to ALAI. Another randomized controlled trial presented in poster form suggested that ALAI 400 mg was comparable with oral aripiprazole 10–30 mg in preventing relapse. ALAI was generally well tolerated during both short-term and long-term studies. Its tolerability profile, including extrapyramidal symptoms and clinically relevant metabolic parameters, was similar to placebo. However, insomnia, headache, anxiety, akathisia, weight gain, injection site pain, and tremor need clinical attention. These studies suggest that ALAI is a viable treatment option for patients with schizophrenia, but direct head-to-head comparisons between ALAI and other long-acting injectable antipsychotics are needed to elucidate its risk–benefit profile.