Prostate gland and its enlargement is a common problem in aging males. Surgery may not be advisable in all cases of enlarged prostate, as the aging people often have other problems such as asthma, diabetes, and blood pressure (BP) and may not often be physically fit to undergo a safe surgery. Case studies were undertaken on two male patients of age 62 and 79 years, respectively. The parameters studied were ultrasonography, pre- and post-void urine volume, and serum prostatic-specific antigen (PSA) along with other physiological and biochemical parameters of BP and diabetes. The patients were tested after 7 days and also after 14 days of yoga practice. In case 1, it was seen that the prostate size, on sonography readings, was reduced from 144 to 37 cc by just 1 month of yoga practice. Prevoid urine volume was 230 ml and postvoid was 180 ml, and after 1 month of yoga practice, it was 694 ml and 19 ml, respectively. Serum PSA initially was 25.24 ng/ml, while at the time of posttesting, it was 0.82 ng/ml. In case 2, the postvoid urine volume was 50 ml initially. On the 14th day of yoga practice, it was nil. Serum PSA was 128.5 ng/ml at the time of pretesting, while on the 14th day, it was 16.35 ng/ml. The prostate size was 91 cc on sonography examination at preyoga testing, while on 14th day of yoga practice, it was 23.6 cc. The yoga module, used in this study, is recommended to be employed to help patients of enlarged prostate.