Background:- Breast cancer is heterogeneous disease with various prognostic factors which play signicant role in deciding plan of management and further prognosis in terms of overall survival (OS) and disease free survival (DFS). The aim of this study was to assess the impact of tumor stage, tumor grade, molecular subtypes and lymph node metastasis on survival of carcinoma breast patients. Retrospective data of Methodology:- 216 post treatment breast cancer patients was collected from hospital records and analyzed. These patients were treated at Department of Radiation Oncology at B.Y.L. Nair Ch. Hospital, Mumbai. Tumor stage, tumor grade, molecular subtypes including immunohistochemical (IHC) parameters like hormonal receptor status and lymph node metastasis were observed. For statistical analysis, chi square test and Kaplan Meier tests were used for signicant correlation and survival analysis respectively. Among 216 patient Results:- s , majority of patients (45.59%) belong to pathological stage II with predominant T2 stage, 93.51 % patients diagnosed with IDC (Invasive Ductal Carcinoma) as common histological type. Most common subtype on basis of immunohistochemistry (IHC) was basal (TNBC) subgroup with 62 (29%) patients. Overall survival was 68.51% with 148 patients survived at end of 5 years and 68 (31.48%) patients died. Stage wise 5 year overall survival rates were 79.41%, 75%, 57.77% for stage I, Stage II, and stage III respectively. Tumor Stage, Nodal Stage and molecula Conclusion:- r subtypes of Breast Cancer were having statistically signicant impact on 5 year survival of patients. Multidisciplinary treatment modalities played important role in complete cure of breast cancer patients which is considered as very complex disease.