Event Abstract Back to Event Physiology and circuitry of frequency tuning in primary auditory cortex Monica N. O’Connell1, 2*, P. Lakatos1, A. Falchier1, A. Barczak1, 3, D. Javitt1, 3 and C.E Schroeder1, 4 1 Cognitive Neuroscience and Schizophrenia Prog., Nathan Kline Institute, United States 2 Prog.Cognitive Neuroscience, City College CUNY, United States 3 Department of Psychiatry, New York University School of Medicine, United States 4 Columbia University College of Physicians and Surgeons, Dep. of Psychiatry, United States In the present study, we investigated the contrasting physiology and laminar activity profiles for characteristic frequency (CF) pure tones vs. non-CF pure tones at sites in primary auditory cortex (A1). We analyzed laminar current source density (CSD) and multiunit activity (MUA) profiles obtained with linear array multicontact electrodes in primary auditory cortex of awake macaques. CSD and MUA index synaptic input patterns (transmembrane current flow) and related neuronal firing patterns respectively. Based on the properties of responses to CF and non-CF tones, we differentiated 2 types of input profiles: “driving” and “modulatory.” The response to driving inputs was characterized by excitation (current sink and MUA increase) beginning in Layer 4, then spreading to the supra- and infragranular layers. This classic “feedforward” activation pattern is predictable from the laminar pattern of ventral MGN neuron projections to A1, with subsequent relay projections to extragranular layers. “Modulatory” CSD responses associated with non-CF tones began in Layers 2/3, followed by the activation of lower layers, accompanied by slight MUA changes noticeable mainly in the granular layer. This type of laminar response profile combined with its early onset in the supragranular layers could be indicative of a “non-specific” or “higher-order” thalamic input. In single trial, time frequency analysis, CF responses fit the criteria of “evoked” processes (i.e., substantial post-stimulus amplitude increase), while non-CF pure tone related activity had the characteristics of “phase-reset” processes (i.e., pre- to post-stimulus phase concentration without an increase in post-stimulus amplitude). In several cases the phase of reset oscillations was frequency specific. We speculate that resetting to low excitability phases by non-characteristic frequency pure tones aids in sharpening/changing the frequency tuning properties of the local neuronal population. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Turkey, 1 Sep - 5 Sep, 2008. Presentation Type: Poster Presentation Topic: Perceptual Processing and Recognition Citation: O’Connell MN, Lakatos P, Falchier A, Barczak A, Javitt D and Schroeder C (2008). Physiology and circuitry of frequency tuning in primary auditory cortex. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.331 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Dec 2008; Published Online: 15 Dec 2008. * Correspondence: Monica N O’Connell, Cognitive Neuroscience and Schizophrenia Prog., Nathan Kline Institute, Orangeburg, United States, oconnell@nki.rfmh.org Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Monica N O’Connell P. Lakatos A. Falchier A. Barczak D. Javitt C.E Schroeder Google Monica N O’Connell P. Lakatos A. Falchier A. Barczak D. Javitt C.E Schroeder Google Scholar Monica N O’Connell P. Lakatos A. Falchier A. Barczak D. Javitt C.E Schroeder PubMed Monica N O’Connell P. Lakatos A. Falchier A. Barczak D. Javitt C.E Schroeder Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.