The advancements in quantum computing and the potential for polynomial-time solutions to traditional public key cryptography (i.e., Rivest–Shamir–Adleman (RSA) and elliptic-curve cryptography (ECC)) using Shor’s algorithm pose a serious threat to the security of pre-quantum blockchain technologies. This paper proposes an efficient quantum-safe blockchain that incorporates new quantum-safe consensus algorithms. We integrate post-quantum signature schemes into the blockchain’s transaction signing and verification processes to enhance resistance against quantum attacks. Specifically, we employ the Falcon signature scheme, which was selected during the NIST post-quantum cryptography (PQC) standardization process. Although the integration of the post-quantum signature scheme results in a reduction in the blockchain’s transactions per second (TPSs), we introduce efficient approaches to mitigate this performance degradation. Our proposed post-quantum delegated proof of luck (PQ-DPoL) combines a proof of luck (PoL) mechanism with a delegated approach, ensuring quantum resistance, energy efficiency, and fairness in block generation. Experimental results demonstrate that while post-quantum cryptographic algorithms like Falcon introduce larger signature sizes and slower processing times, the PQ-DPoL algorithm effectively balances security and performance, providing a viable solution for secure blockchain operations in a post-quantum era.