Introduction: due to the current geopolitical situation, the results of scientific research must go far beyond the fundamental level and find application in the real sector of the economy. This is a key vector of the national scientific and technological policy, justified by the urgent need for import-substituting technologies that have emerged as a result of the global crisis, the COVID-19 pandemic and sanctions pressure. The research focuses on analyzing the development of scientific and scientific-technical projects after they have received state support. Objectives: to analyze the experience of the Krasnoyarsk Regional Fund of Science and Technology Support in monitoring the projects' relevance. Methods: post-project monitoring, continuous questionnaires, statistical and graphical analysis, and system analysis. Results: an analysis of the development of projects that received state support, conducted using post-project monitoring, showed that 8% of the total number of respondents commercialized the results of their projects, 37% introduced their results into socio-economic turnover in organizations operating in the Krasnoyarsk Krai. Conclusions: more than a third of all projects supported by the Krasnoyarsk Regional Fund of Science and Technology Support have received some form of further development or practical application in one form or another, which exceeds the average statistical data provided in other studies. However, there is still a need to increase the level of commercialization of scientific projects' outputs. The authors proposed a number of measures to achieve this goal.