Irvingiagabonensis is a valuable food commodity in West and Central Africa, but post-harvest fungal contamination and mycotoxin accumulation pose significant challenges to itsquality and safety. This study investigated the effects of post-harvest temperature treatments(50, 60, 70, and 80°C) on fungal growth and mycotoxin levels in I. gabonensis kernels.Fungal growth was assessed by determining the colony-forming units per gram (CFU/g),while mycotoxin levels (aflatoxins and fumonisins) were quantified using high-performanceliquid chromatography (HPLC). The results showed that higher temperature treatments,particularly at 70°C and 80°C, significantly reduced both fungal growth and mycotoxin levelscompared to lower temperature treatments (50°C and 60°C). The 80°C treatment was themost effective, resulting in an 82.9% reduction in fungal growth, an 82.5% reduction in totalaflatoxins, and a 73.2% reduction in total fumonisins compared to the 50°C treatment. Thefindings highlight the importance of post-harvest temperature management in ensuring thequality and safety of I. gabonensiskernels and provide a basis for the development ofimproved post-harvest practices to reduce fungal contamination and mycotoxin exposure.