Possibility Of Early Diagnosis Research Articles

Effects of the Regular Use of Virtual Environments on Spatial Navigation and Memory.

Introduction: The cognitive effects of video games have garnered increasing attention due to their potential applications in cognitive rehabilitation and evaluation. However, the underlying mechanisms driving these cognitive modifications remain poorly understood. Objectives: This study investigates the fundamental mnemonic processes of spatial navigation, pattern separation, and recognition memory, closely associated with the hippocampus. Our objective is to elucidate the interaction of these cognitive processes and shed light on rehabilitation mechanisms that could inform the design of video games aimed at stimulating the hippocampus. Method: In this study, we assessed 48 young adults, including both video game players and non-players. We utilized virtual reality and cognitive tasks such as the Lobato Virtual Water Maze and the Mnemonic Similarity Task to evaluate their cognitive abilities. Results: Our key findings highlight that gamers exhibit heightened pattern separation abilities and demonstrate quicker and more accurate spatial learning, attributed to the cognitive stimulation induced by video games. Additionally, we uncovered a significant relationship between spatial memory, guided by environmental cues, and pattern separation, which serves as the foundation for more efficient spatial navigation. Conclusions: These results provide valuable insights into the cognitive impact of video games and offer potential for monitoring changes in rehabilitation processes and early signs of cognitive decline through virtual reality-based assessments. Ultimately, we propose that examining the relationships between cognitive processes represents an effective method for evaluating neurodegenerative conditions, offering new possibilities for early diagnosis and intervention.

Novel CAD Diagnosis Method Based on Search, PCA, and AdaBoostM1 Techniques.

Background: Cardiovascular diseases (CVDs) are the primary cause of mortality worldwide, resulting in a growing number of annual fatalities. Coronary artery disease (CAD) is one of the basic types of CVDs, and early diagnosis of CAD is crucial for convenient treatment and decreasing mortality rates. In the literature, several studies use many features for CAD diagnosis. However, due to the large number of features used in these studies, the possibility of early diagnosis is reduced. Methods: For this reason, in this study, a new method that uses only five features-age, hypertension, typical chest pain, t-wave inversion, and region with regional wall motion abnormality-and is a combination of eight different search techniques, principal component analysis (PCA), and the AdaBoostM1 algorithm has been proposed for early and accurate CAD diagnosis. Results: The proposed method is devised and tested on a benchmark dataset called Z-Alizadeh Sani. The performance of the proposed method is tested with a variety of metrics and compared with basic machine-learning techniques and the existing studies in the literature. The experimental results have shown that the proposed method is efficient and achieves the best classification performance, with an accuracy of 91.8%, ever reported on the Z-Alizadeh Sani dataset with so few features. Conclusions: As a result, medical practitioners can utilize the proposed approach for diagnosing CAD early and accurately.

Office-based management of non-muscle invasive bladder cancer (NMIBC): a position paper on current state of the art and future perspectives.

To the Editor, Bladder cancer is one of the most common cancers in humans, representing the 7th and 17th type of neoplasm in both genders. Its incidence and mortality are quite heterogeneous in different countries and are due to different risk factors, quality and prevalence of healthcare and the possibility of early diagnosis and treatment of the tumor and its potential recurrences. [...].

Application of an end-to-end model with self-attention mechanism in cardiac disease prediction.

Introduction: Heart disease is a prevalent global health challenge, necessitating early detection for improved patient outcomes. This study aims to develop an innovative heart disease prediction method using end-to-end deep learning, integrating self-attention mechanisms and generative adversarial networks to enhance predictive accuracy and efficiency in healthcare. Methods: We constructed an end-to-end model capable of processing diverse cardiac health data, including electrocardiograms, clinical data, and medical images. Self-attention mechanisms were incorporated to capture data correlations and dependencies, improving the extraction of latent features. Additionally, generative adversarial networks were employed to synthesize supplementary cardiac health data, augmenting the training dataset. Experiments were conducted using publicly available heart disease datasets for training, validation, and testing. Multiple evaluation metrics, including accuracy, recall, and F1-score, were employed to assess model performance. Results: Our model consistently outperformed traditional methods, achieving accuracy rates exceeding 95% on multiple datasets. Notably, the recall metric demonstrated the model's effectiveness in identifying heart disease patients, with rates exceeding 90%. The comprehensive F1-score also indicated exceptional performance, achieving optimal results. Discussion: This research highlights the potential of end-to-end deep learning with self-attention mechanisms in heart disease prediction. The model's consistent success across diverse datasets offers new possibilities for early diagnosis and intervention, ultimately enhancing patients' quality of life and health. These findings hold significant clinical application prospects and promise substantial advancements in the healthcare field.

Knowledge about Cervical Cancer Prevention and Screening in Women with Cervical Cancer Attending Gynecological Services in Southern Mozambique.

Mozambique has high rates of cervical cancer and cancer-related deaths among women. A high rate of refusal and low acceptance of treatment is observed among cervical cancer patients. The extent of their knowledge of the disease is unknown. To assess knowledge about this disease (prevention, risk factors, and the possibilities of early diagnosis) in women with cervical cancer attended in gynecological services in Gaza province, Mozambique. This cross-sectional study took place in the city of Xai-Xai at the Provincial Hospital of Xai-Xai (HPXX) in the southern province of Gaza (Mozambique). Non-probability convenience sampling was used. Eligible patients (women) aged 35-50 years, diagnosed with cervical cancer and followed at the HPXX in the second quarter of 2021 (n = 60), took part in the survey during their scheduled consultations. Descriptive statistics were calculated using SPSS statistical software (version 16). The study included 60 women, 39 (65%) HIV positive. More than half (55.0%) believed that having a single sexual partner was an effective form of prevention; 50.0% reported that excessive alcohol consumption and having many sexual partners could cause the disease, and 46.7% affirmed that having many children increased the risk. Thirty-eight (63.3%) women reported that early diagnosis of cervical cancer was important for receiving prompt treatment, and 54 (90.0%) said regular visits to the gynecologist were important for an early diagnosis. Thirty-five (58.3%) mentioned acetic acid screening as a diagnostic test. There are significant gaps in awareness of cervical cancer among high-risk groups.

Anesthesia and rare neuromuscular diseases

Neuromuscular diseases, although rare in the general population, can be present in people who need to undergo surgery and anesthesia. Fortunately, the possibility of early diagnosis, new therapeutic approaches and the application of a multidisciplinary approach have significantly extended the life expectancy of such patients. The presence of such a disorder represents a challenge in anesthesiology practice, both during the preparation for surgery itself, the operative procedure and postoperative recovery in intensive care units. A basic understanding of the main disorders of the disease and their potential interactions with the anesthetic itself and the necessary agents in anesthesiology is necessary in order to reduce the risk of perioperative morbidity and mortality, with the aim of reducing the possibility of complications. Rare muscle diseases are very difficult to classify in a standard way because of the variability of their etiology and pathology. This work focuses on a number of muscle diseases such as Dubowitz syndrome, rhabdomyosarcoma in children, spinal muscular atrophy, Kennedy's disease, Congenital muscular dystrophy of the Ullrich type (UCMD), Sotos syndrome, Polymyositis and Setleis syndrome, Nemaline rod myopathy, Pompe disease, Emery-Dreifuss muscular dystrophy (EDMD). The medical literature on anesthetic techniques and perioperative complications was reviewed. Given that they can have a very unfavorable effect on the course of general anesthesia in particular and that these diseases can cause very serious, even life-threatening complications, an adequate anesthesiological approach is very important to reduce the possibility of the mentioned complications. A multidisciplinary approach is imperative for such patients before and after surgery, whether it is performed under analgosedation, some type of regional or general anesthesia. The operative procedure itself must be performed in institutions that are adequately equipped to treat such patients and by personnel who have experience in treating them.

One-year results of the national breast and cervical cancer screening program: Giresun province in the black sea region

Background/Aim: Increasing the survival rate of patients with breast and cervical cancers is possible by early diagnosis through screening individuals for cancer in the asymptomatic period. Especially during the COVID-19 pandemic period, the possibility of early diagnosis in breast and cervical cancers has decreased due to the decrease in cancer screening applications. The aim of cancer screening is to increase the survival of patients by detecting precancerous lesions early. The purpose of our study is to evaluate the application and results of breast and cervical cancer screening in the Black Sea region’s Giresun province. Methods: This is a cross-sectional and descriptive study. The results of patients who were admitted to the Giresun Early Diagnosis Cancer Screening and Education Center between July 1, 2021, and June 28, 2022, were examined. The mammography report results of women aged 40–69 years who applied to the cancer screening center for breast cancer screening, and the HPV and Pap smear results of the patients aged 30–65 years who applied for cervical cancer screening, were evaluated retrospectively through the public health management system. Mammography results were evaluated with BIRADS (Breast Imaging Reporting and Dated System) scoring. The type of HPV and the cytology results from cervical swab samples were analyzed for cervical cancer screening. Results: A total of 3567 people underwent mammography. Per the mammography results, the percentage of those with BIRADS 0 was 7.7% (n=278), the percentage of those with BIRADS 1–2 was 91% (n=3256), the percentage of those with BIRADS 4 was 0.7% (n=25), and the percentage of those with BIRADS 5 was 0.14% (n=5). HPV-DNA and cervical cytology examinations were performed for cervical cancer screening in 2326 patients. As a result of cervical cancer screening, HPV positivity was found in 6.44% (n=150) patients, and 14 different HPV types were found in the positive samples. When HPV types were examined, the two most common types were HPV type 16 (13.6%) and type 56 (11.9%). When the HPV types were examined in the positive samples, the two most common types were HPV type 16 (13.6%) and type 56 (11.9%). HPV type 18 was the least detected HPV type in patients (3.7%). When the Pap smear screening results of the 150 cases with positive screening results were examined, 3.33% were ASC-US (atypical squamous cells of undetermined significance), 22% were reported as infection, and 62.6% were normal. Conclusion: The role of primary care physicians directing patients registered in their coverage area to cancer screening programs is especially effective in raising society’s awareness and education on the issue. As a result, it is important that primary care physicians and related specialist physicians, together with cancer early detection and screening centers, adopt a supportive stance towards these programs in order for them to be implemented effectively.

The Promising Role of Non-Coding RNAs as Biomarkers and Therapeutic Targets for Leukemia.

Early-stage leukemia identification is crucial for effective disease management and leads to an improvement in the survival of leukemia patients. Approaches based on cutting-edge biomarkers with excellent accuracy in body liquids provide patients with the possibility of early diagnosis with high sensitivity and specificity. Non-coding RNAs have recently received a great deal of interest as possible biomarkers in leukemia due to their participation in crucial oncogenic processes such as proliferation, differentiation, invasion, apoptosis, and their availability in body fluids. Recent studies have revealed a strong correlation between leukemia and the deregulated non-coding RNAs. On this basis, these RNAs are also great therapeutic targets. Based on these advantages, we tried to review the role of non-coding RNAs in leukemia. Here, the significance of several non-coding RNA types in leukemia is highlighted, and their potential roles as diagnostic, prognostic, and therapeutic targets are covered.

Epidemiologija raka pankreasa

Pancreatic cancer is the seventh leading cause of cancer-related deaths and the twelfth most common cancer worldwide. Incidence and mortality rates vary from country to country, which is a consequence of exposure to different risk factors, the possibilities of early diagnosis and timely and adequate treatment. It is estimated that by 2040, there will be a further increase in the number of patients (e.g. by 27.4% in Europe) and deaths (e.g. by 28.5% in Europe) caused by pancreatic cancer. According to the National Cancer Institute of the United States of America, the average five-year survival rate for pancreatic cancer is 12%. Modifiable and non-modifiable factors contribute to the occurrence of this tumor. Pancreatic cancer occurs more often in the elderly, men, tobacco and alcohol users, people with diabetes, chronic pancreatitis, physically inactive and obese people, as well as in people with a positive family history of this malignant tumor. It is necessary to work on educating the population about the risk factors for pancreatic cancer, the possibilities of prevention and ways of early diagnosis of this disease.

Psychological and mental aspects of increased tooth abrasion

The analysis of literary and other information sources (in PubMed, Google Scholar, KiberLeninka and eLibrary databases) devoted to the study of dental manifestations of psychological conditions and the analysis of the ability of dentists to identify psychological predictors of increased tooth erasure in adolescents and young people. Disorders such as stress, depression, attention deficit hyperactivity disorder, alcohol dependence, eating disorders - may be risk factors for the development of increased tooth abrasion. Comorbid conditions such as bruxism and gastroesophageal reflux are also considered. Due to the high mortality of adolescents due to mental illness, early diagnosis of disorders of psychological and mental health of adolescents is extremely relevant. Attention is focused on the possibility of early diagnosis by dentists of psychological and mental problems by the presence and type of increased erasability of teeth. Effective examination and treatment of such patients requires a holistic, interdisciplinary approach.

Diagnostic of small choroidal metastasis

Choroidal metastasis in 23–30 % of cases have multifocal growth. In 10–20 % of patients do not have subjective complaints, due to eccentrical localization of choroidal metastases. In these cases, they are detected by chance during examination. In the literature there is no information on the possibility of early diagnosis of “small” foci of metastatic lesions of the choroid using optical coherence tomography (OCT).The aim. To identify diagnostic signs of “small” choroidal metastases.Materials and methods. The study included 4 patients in whom “small” metastases (15 foci) were not visualized by ultrasound.Results. Choroidal metastases, which were not detected by ultrasound, mainly characterized by a multifocal growth pattern, and located mainly outside the central regions of the fundus. The OCT picture in these cases was characterized by the expansion of the choroidal complex up to 1300 μm with an asymmetric shape of the slopes, irregularities of its anterior surface with a moderate hyporeflective structure. At the same time, Bruch’s membrane was preserved, but a violation of the architectonics of the choriocapillary layer is characteristic with a flat profile of the anterior surface of the sclera. Secondary changes in the proper retina are represented by thickening of the retinal pigment epithelium, edema of the photoreceptor layer and of the nuclear layers, while neuroepithelium detachment (NED) appears mainly when the focus is more than 400 μm thick. Initially, choroidal metastasis can be detected by the fundus examination in MultiColor and OCT, as changes appear in the retina – edema of the photoreceptor layer with hyperreflective inclusions and NED, changes appear in the blue-peak autofluorescence (BAF) – hyperBAF with point hypoBAF inclusions, which leads to a change fundus pictures in MultiColor mode.Conclusion. For all patients with a burdened oncological history, even in the absence of visual complaints, in addition to an examination of the fundus of both eyes, it is necessary to provide an examination of the fundus in MultiColor and short-wave autofluorescence modes, followed by OCT in the zones of changes.

The system of personal early non-invasive diagnosis of cardiac conditions as an element of the cyber physical system

In the 21st century, the most common cause of death in the developed countries is cardio. The Covid’19 pandemic only confirms this claim that the circulatory system and the heart are possible. That is why, even during a pandemic, the quality of cardio remains paramount. The significant cost of solving each element of these problems is the main driver of the idea of developing the ideology of preliminary diagnostics, as it allows you to more quickly (and therefore more effectively) respond to problems. In addition, today in Ukraine (and in the world as well) the cost of medical care is growing rapidly and not every society can afford to pay for medical services according to the usual rules of 20th century. One of the solutions that Ukraine is familiar with is that the pressure measurement is now done independently, and not an ambulance is called (doctor, nurse / brother, driver). The authors set themselves the task of exploring the following possibility in the problem of preliminary diagnostics to reduce the burden on the medical system. The aim of the work is to test the hypothesis of the possibility of early detection of cardio abnormalities by developing / creating an individual mobile device for preliminary diagnosis of the condition. In particular, on the example of monitoring the most common problem, rapid early diagnosis based on cardio signals. The main advantage of using the studied approach is the possibility of early diagnosis (rapid response) to complications, which is read by the sensor and analyzed by the analytical system (monitoring system). A basic study and experimentally tested the basic hypotheses are presented in the paper. The level and number of basic tasks that need to be solved to achieve the ultimate goal are checked. The basic concept of a personal intellectual advisor is tested. The results obtained during the experiments are visualized.

Rat prostate tumors induce DNA synthesis in remote organs

Advanced cancers induce systemic responses. However, if such systemic changes occur already when aggressive tumors are small, have not been thoroughly characterized. Here, we examined how localized prostate cancers of different sizes and metastatic potential affected DNA synthesis in the rest of the prostate and in various remote organs. Non-metastatic Dunning R-3327 G (G) tumor cells, metastatic MatLyLu (MLL) tumor cells, or vehicle were injected into the prostate of immunocompetent rats. All animals received daily injections of Bromodeoxyuridine (BrdU), to label cells/daughter cells with active DNA synthesis. Equal sized G- and MLL-tumors, similarly increased BrdU-labeling in the prostate, lymph nodes and liver compared to tumor-free controls. Prior to metastasis, MLL-tumors also increased BrdU-labeling in bone marrow and lungs compared to animals with G-tumors or controls. In animals with MLL-tumors, BrdU-labeling in prostate, lungs, brown adipose tissue and skeletal muscles increased in a tumor-size-dependent way. Furthermore, MLL-tumors induced increased signs of DNA damage (γH2AX staining) and accumulation of CD68 + macrophages in the lungs. In conclusion, small localized prostate cancers increased DNA synthesis in several remote tissues in a tumor type- and size-dependent way. This may suggest the possibility for early diagnosis of aggressive prostate cancer by examining tumor-induced effects in other tissues.

Clinical heterogeneity in the early diagnosis of psoriatic arthritis

Introduction PsA are included in the group of HLA-B27-associated joint diseases, united in the group of seronegative spondylitis (SSA). At the same time, this disease differs from ankylosing spondylitis and other spondylitis with a particularly diverse clinical picture and the existence of only the syndromes inherent in it, for example, intermittent synovitis, palindromic rheumatism or mutilating arthritis. Purpose of the study Research of clinical heterogeneity of early psoriatic arthritis and the possibility of early diagnosis. Materials and methods The current study included 104 patients with PsA who were admitted to the rheumatology and arthrology departments of the Republican Clinical Hospital „Timofei Moşneaga” from 2003 to October 2021. Results The frequency of expression of individual clinico-anatomical variants of joint syndrome was different in patients with PsA-e and PsA-t (in PsA-e compared to PsA-t, the oligoarticular variant was significantly more likely to be observed (43.1% and 19%, respectively, p=0.01) and less often the variant of spondyloarthritis (7.8% and 19%, p=0.1), while the variant of polyarthritis (33.3% and 38%, p = 0,6) and distal interphalangeal (15,7% and 15%, p=0,9) were detected with the same frequency, as regards the mutilating variant, this was observed only in PsA-t. Conclusions The early stage of psoriatic arthritis is characterized by pronounced heterogeneity of manifestations of joint syndrome and damage to the tendon-ligament apparatus. In PsA-e oligoarthritis and polyarticular variants are the most common, less often - distal interphalangeal and spondyloarthritic. In the first 3 months after the onset of clinical manifestations of PsA, oligoarthritis was observed in 75.4% of patients and polyarthritis in 14% (p=0.0001), and after 6 months - 63% and 26.6% respectively (p=0.001). With a progression of the duration of the disease, the number of patients with arthritis increased, and by the end of the 2nd year was determined in 47.6% of patients, and oligoarthritis - in 28.6%.

Multiple roles of m6A methylation in epithelial-mesenchymal transition.

Epithelial-mesenchymal transition (EMT) plays an important role in migration and invasion of cancer cell and the development of tissue fibrosis diseases. N6-methyladenosine (m6A) is the most extensive type of RNA methylation and has aroused extensive interest in recent years. However, m6A methylation seems to play different roles in different cancer cells and tissue fibrotic diseases. To determine the function of m6A methylation in EMT, we summarized the molecular mechanism of EMT and recent progress in the regulation of EMT by m6A methylation, suggesting that m6A methylation targets EMT program by affecting the expression of transcription factors, EMT markers, long noncoding RNA and EMT-associated signaling pathways, which provides more possibilities for early diagnosis and treatment.

Multiomics approaches to search for molecular-genetic predictors of osteoporosis

The identification of genetic loci and biochemical markers associated with the risk of fractures and the level of bone mineral density (BMD) did not give an unambiguous answer about the molecular pathogenesis of osteoporosis (OP). There are still unresolved questions about the possibility of early diagnosis and prognosis of the course of the disease. The molecular effects of genetic variants located in the coding regions of the human genome are easy to study. However, most of the single nucleotide polymorphic loci that are associated with osteoporosis susceptibility are located in non-coding or intergenic regions. Their role in the pathogenesis of this disease is not fully understood. The use of biochemical markers in the diagnosis and monitoring of osteoporosis therapy does not allow developing approaches to early diagnosis of the disease before a fracture occurs. Significant problems arise in the interpretation of research results for use in clinical medicine. But the combination of multidisciplinary data, such as genome-wide association study (GWAS), changes in the patterns of biogenic elements of bone remodeling, catalytic activity of a number of enzymes, and protein expression has significantly expanded the understanding of the key links in the pathogenesis of the disease. The article reviews and summarizes the latest advances in multiomics studies of osteoporosis, including bionformatic analysis to find key risk factors for the development of OP, as well as pharmacogenetic aspects of modern therapy of the disease.

The possibility of early diagnosis of colorectal cancer through expression of Lncrna UCA1, Lncrna LINC00970, and Wnt genes; an in-vitro study

Colorectal cancer is the 4th cause of cancer death; with considering the growth process of this cancer and the necessity of early diagnosis, the purpose of the research is to state the LncRNA 00970, LncRNA UCAI, and the Wnt gene before and after the treatment by 5-Azacytidine epigenetic medicine, to reach the biomarker in the very first steps of colorectal cancer. In this experiment, the human colon cancer cell line (HT29) treated with different concentrations of 5-aza-2’-deoxycytidine (5-aza-dC) was utilized to induce DNA demethylation; Quantitative PCR (qPCR) was used to measure LncRNA UCA1 and LncRNA LINC00970 and Wnt expression. There was a significant relationship between the expression of LncRNA 00970, LncRNA UCAI, and the Wnt gene and its effects on colorectal (p < 0.05). The Wnt gene was treated by 1 and 10 of 5-Azacytidine epigenetic medicine, which then experienced decreases. In LncRNA UCAI and LncRNA00970 in dose 1 micromolar of 5-Azacytidine had decrement and increment of expression respectively that explains their efficiency but in treatment by dose 10 mM of this medicine, no significant LncRNA expression difference was detected, 5-azacitidine has a direct impact on its target genes and LncRNAs. Therefore, it can be used in the early diagnosis of colorectal cancer.

Contribution to the Struggle Against Chromosomal Abnormalities from Literature Review

Chromosomal abnormalities have a variable severity, which can range from lethality before birth to the need for permanent medical care. The objective of this work was to propose a strategy to the struggle against chromosomal abnormalities through Departments of cytogenetics from literature review. Several documents have been consulted on the activities of Departments (or Services) of cytogenetics in relation to health care, ethical, legal and social problems concerning chromosomal abnormalities. In addition there are teaching and international collaboration in the field of cytogenetics. The corresponding articles have been published in journals with editorial, reading and scientific committees. According to this literature review, Services of cytogenetics should emphasize appropriate technologies and affordable prices, which can reach a significant portion of the population. In these Services, genetic counseling respects the right to full information and possible solutions regarding chromosomal abnormalities. Prevention through community sensitization, screening of populations and the possibility of early diagnosis should be carried out. The teaching of cytogenetics is therefore the starting point from which programs to combat chromosomal abnormalities will be introduced. Departments of cytogenetics must be supported by regulatory structures constituted by the scientific, medical and non-professional communities. Research is an important component of medical cytogenetics as well as international collaboration. This work includes a set of coordinated actions whose implementation would deal with chromosomal abnormalities.

ЮВЕНИЛЬНЫЙ ИДИОПАТИЧЕСКИЙ АРТРИТ И СИСТЕМНАЯ КРАСНАЯ ВОЛЧАНКА В ДЕТСКОМ ВОЗРАСТЕ: ЧАСТОТА, ПРИЧИНЫ, КЛАССИФИКАЦИЯ, КЛИНИЧЕСКИЕ ПРОЯВЛЕНИЯ

Juvenile idiopathic arthritis (JIA) is one of the most common and most disabling rheumatic diseases in children. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown etiology, which is based on a genetically determined dysregulation of immunity. In recent years, the view of JIA and SLE as potentially incurable and prognostically unfavorable diseases has been revised. This is largely due to the expansion of the possibilities of early diagnosis of JIA, SLE, which allows starting active therapy at the onset of the disease, the development of a new class of basic anti-inflammatory drugs, and scientific research in the genetics of both diseases. A large number of genes associated with immune responses can, induce an autoimmune response - the leading pathogenetic link in both diseases. The article presents modern data on the possible pathogenesis, spectrum of clinical manifestations of juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE) in children. A brief description of the pathological changes in JIA and SLE is given. Possible factors are considered, incl. genetic, affecting the predisposition to the disease, the process of the formation of organ damage. The issues of assessing the activity of diseases, assessing the quality of life of patients are discussed in detail.

NEUROFIBROMATOSIS TYPE I AND ITS DIAGNOSTIC CRITERIA: A CLINICAL OBSERVATION.

The aim - to consider the etiopathogenesis, the main clinical manifestations, diagnostic criteria of NF1, and present a clinical case from their practice. The paper analyzes the research findings in recent publications, focused on the studied issue using the methods of continuous sampling, synthesis and generalization, bibliosemantic evaluation and content analysis. In order to attract the attention of family physicians, neurologists, dermatologists, ophthalmologists, surgeons and other specialists, we present our own clinical observation of NF1. The patient was examined using the methods of neurological examination, as well as other laboratory and instrumental methods of research. Early diagnosis and medical examination of patients with NF1 is crucial for predicting and improving the quality of life of patients. NF1 is a complex disease where the cooperation of doctors of different specialties is important. A favorable prognosis for patients is associated with the possibility of early diagnosis of malignant transformation and timely treatment.