By utilizing the properties of positive definite matrices, mathematical expectations, and positive linear functionals in matrix space, the Kantorovich inequality and Wielandt inequality for positive definite matrices and random variables are obtained. Some novel Kantorovich type inequalities pertaining to matrix ordinary products, Hadamard products, and mathematical expectations of random variables are provided. Furthermore, several interesting unified and generalized forms of the Wielandt inequality for positive definite matrices are also studied. These derived inequalities are then exploited to establish an inequality regarding various correlation coefficients and study some applications in the relative efficiency of parameter estimation of linear statistical models.