For a positive integer m, a (positive definite integral) quadratic form is called primitively m-universal if it primitively represents all quadratic forms of rank m. It was proved in [9] that there are exactly 107 equivalence classes of primitively 1-universal quaternary quadratic forms. In this article, we prove that the minimal rank of primitively 2-universal quadratic forms is six, and there are exactly 201 equivalence classes of primitively 2-universal senary quadratic forms.