The aim of this study was to assess the eventual added benefit of anti- granulocyte monoclonal antibodies scintigraphy to the diagnostic imaging of aortic graft infection and its role in evaluation of treatment outcome. A population-based, retrospective, register-based analysis was carried out of all patients with infected aortic grafts after treatment for aneurysmal or aortoiliac occlusive disease (AIOD) at Karolinska University Hospital, covering the greater Stockholm area during Nov-2012-Dec-2020. Cases were based on the definitions in the 2016 MAGIC (Management of Aortic Graft Infection Collaborations) consensus. Using the in-hospital electronic patient registry (Take Care®) and the Swedish National Registry for Vascular Surgery (Swedvasc), 835 patients who had been treated for aortic aneurysms or AIOD were identified. The diagnostic arsenal of laboratory tests, CT and clinical signs has been supplemented by anti-G mAb scintigraphy. Data were analyzed using SPSS Statistics. Eighteen cases of AGI out of 835 operations incorporating aortic grafts during the period were identified. Fourteen patients (78%) were categorized as diagnosed AGI (AGI-D) and the remaining four (22%) were classified as suspected AGI (AGI-S). In the AGI-D group (n=14), ten patients (71%) had positive CTs and four (29%) had low probability CTs. In the group of ten positive CTs nine patients had also positive scintigraphy scans with only one negative scintigraphy scan. There were no negative scintigraphy scans without ongoing antibiotic treatment at the time of investigation. In 15 of 18 cases a culprit agent was identified, either pre-operatively or perioperatively. Thirteen of the 18 patients were treated solely by antibiotics whereas five patients underwent surgical treatment in addition to antibiotic treatment. The outcome has been divided into three groups: infection free (n=6; 33%); life-long antibiotic treatment (n=7; 39%) and deceased (n=5; 28%). The imaging modalities in AGI diagnostics are a cornerstone of the investigative work up, complemented by clinical signs and laboratory methods. The main advantage conveyed by anti-G mAb scintigraphy is in postoperative imaging and its ability to differentiate between infection and general postoperative changes in the areas of concern. We have identified six patients in our cohort in whom antibiotic therapy was discontinued after a negative anti-G mAb scintigraphy scan. Anti-G mAb scintigraphy may fulfill a unique need for diagnosis in suspected cases, evaluation of therapeutic efficacy in patients requiring long-term antibiotic treatment and aiding in the decision to discontinue antibiotic therapy.