To explore the relationship between midwives' psychological resilience and posttraumatic growth, and the mediating role of perceived stress and positive coping strategies. A multicentre cross-sectional survey was used. Data were conducted among 339 midwives from 24 Grade III A hospitals in Sichuan Province from April to July 2023, using the Chinese version of the Connor Davidson Resilience Scale, Chinese version Perceived Stress Scale, Simplified Coping Style Questionnaire, Chinese-Posttraumatic Growth Inventory and General Demographic Data Questionnaire. A descriptive statistical approach, Pearson's correlation analysis and the Mplus 8.3 were used to analyse the available data. There was a significant correlation between psychological resilience, perceived stress, positive coping strategies and PTG. Psychological resilience could have a direct positive impact on PTG of midwives, but it could also indirectly affect PTG of midwives through three pathways: the mediating effect of perceived stress, the mediating effect of positive coping strategies and the chain mediating effect of perceived stress and positive coping strategies. Results suggest that nursing managers should help to improve the psychological resilience of midwives and to reduce individual stress perception, enhance coping abilities and achieve positive growth. Prior to data collection, we obtained approval from the nursing department of each hospital. Midwives who met the inclusion and exclusion criteria gave informed consent and invited to participate in this study. This study was guided by STROBE. During the data collection phase, 349 midwives took the time to carefully answer the questionnaire items related to this study.